| Literature DB >> 28118599 |
Kirsten L Bryant1, Channing J Der2.
Abstract
Mutant RAS-driven cancers are infamously resistant to chemotherapeutics. Reporting in Cell, Grabocka and Bar-Sagi (2016) demonstrate that when subjected to stress, mutant KRAS-dependent lipid production leads to upregulated stress granule formation. This confers not only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor niche.Entities:
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Year: 2017 PMID： 28118599 PMCID： PMC6484846 DOI： 10.1016/j.devcel.2017.01.005
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270