| Literature DB >> 28112723 |
Claire Chewapreecha1,2,3, Matthew T G Holden2,4, Minna Vehkala5, Niko Välimäki6, Zhirong Yang5, Simon R Harris2, Alison E Mather7, Apichai Tuanyok8, Birgit De Smet9,10, Simon Le Hello11, Chantal Bizet12, Mark Mayo13, Vanaporn Wuthiekanun14, Direk Limmathurotsakul14,15,16, Rattanaphone Phetsouvanh17, Brian G Spratt18, Jukka Corander5,19, Paul Keim20, Gordon Dougan1,2, David A B Dance16,17,21, Bart J Currie13, Julian Parkhill2, Sharon J Peacock1,2,21.
Abstract
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.Entities:
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Year: 2017 PMID： 28112723 PMCID： PMC5300093 DOI： 10.1038/nmicrobiol.2016.263
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745