Qi Yang1,2, Zixin Deng2,3, Xiaoming Bi4, Shlee S Song5, Konrad H Schlick5, Nestor R Gonzalez6, Debiao Li2,3, Zhaoyang Fan2. 1. Department of Radiology, Xuanwu Hospital, Beijing, China. 2. Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA. 3. Department of Bioengineering, University of California, Los Angeles, California, USA. 4. MR R&D, Siemens Healthcare, Los Angeles, California, USA. 5. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA. 6. Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Abstract
PURPOSE: To propose and evaluate a parameter tune-up solution to expedite a three-dimensional (3D) variable-flip-angle turbo spin-echo (TSE) sequence for whole-brain intracranial vessel wall (IVW) imaging. MATERIALS AND METHODS: Elliptical k-space sampling and prolonged echo train length (ETL), were used to expedite a 3D variable-flip-angle TSE-based sequence. To compensate for the potential loss in vessel wall signal, optimal combination of prescribed T2 and ETL was experimentally investigated on 22 healthy volunteers at 3 Tesla. The optimized protocol (7-8 min) was then compared with a previous protocol (reference protocol, 11-12 min) in terms of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), vessel wall sharpness, and wall delineation quality on a 4-point scale (0:poor; 3:excellent) in 10 healthy volunteers. A pilot study of five patients was performed and lesion delineation score was used to demonstrate the diagnostic quality. RESULTS: A protocol with ETL = 52 and prescribed T2 = 170 ms was deemed an optimized one, which, compared with the reference protocol, provided significantly improved wall SNR (12.0 ± 1.3 versus 10.0 ± 1.1; P = 0.002), wall-lumen CNR (9.7 ± 1.2 versus 8.0 ± 0.9; P = 0.002), wall-CSF CNR (2.8 ± 1.0 versus 1.7 ± 1.0; P = 0.026), similar vessel wall sharpness at both inner (1.59 ± 0.18 versus 1.58 ± 0.14, P = 0.87) and outer (1.71 ± 0.25 versus 1.83 ± 0.30; P = 0.18) boundaries, and comparable vessel wall delineation score for individual segments (1.95-3; P > 0.06). In all patients, atherosclerotic plaques (10) or wall dissection (5) were identified with a delineation score of 3 or 2. CONCLUSION: A parameter tune-up solution can accelerate 3D variable-flip-angle TSE acquisitions, particularly allowed for expedited whole-brain IVW imaging with preserved wall delineation quality. LEVEL OF EVIDENCE: 2. Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:751-757.
PURPOSE: To propose and evaluate a parameter tune-up solution to expedite a three-dimensional (3D) variable-flip-angle turbo spin-echo (TSE) sequence for whole-brain intracranial vessel wall (IVW) imaging. MATERIALS AND METHODS: Elliptical k-space sampling and prolonged echo train length (ETL), were used to expedite a 3D variable-flip-angle TSE-based sequence. To compensate for the potential loss in vessel wall signal, optimal combination of prescribed T2 and ETL was experimentally investigated on 22 healthy volunteers at 3 Tesla. The optimized protocol (7-8 min) was then compared with a previous protocol (reference protocol, 11-12 min) in terms of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), vessel wall sharpness, and wall delineation quality on a 4-point scale (0:poor; 3:excellent) in 10 healthy volunteers. A pilot study of five patients was performed and lesion delineation score was used to demonstrate the diagnostic quality. RESULTS: A protocol with ETL = 52 and prescribed T2 = 170 ms was deemed an optimized one, which, compared with the reference protocol, provided significantly improved wall SNR (12.0 ± 1.3 versus 10.0 ± 1.1; P = 0.002), wall-lumen CNR (9.7 ± 1.2 versus 8.0 ± 0.9; P = 0.002), wall-CSF CNR (2.8 ± 1.0 versus 1.7 ± 1.0; P = 0.026), similar vessel wall sharpness at both inner (1.59 ± 0.18 versus 1.58 ± 0.14, P = 0.87) and outer (1.71 ± 0.25 versus 1.83 ± 0.30; P = 0.18) boundaries, and comparable vessel wall delineation score for individual segments (1.95-3; P > 0.06). In all patients, atherosclerotic plaques (10) or wall dissection (5) were identified with a delineation score of 3 or 2. CONCLUSION: A parameter tune-up solution can accelerate 3D variable-flip-angle TSE acquisitions, particularly allowed for expedited whole-brain IVW imaging with preserved wall delineation quality. LEVEL OF EVIDENCE: 2. Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:751-757.
Authors: Anja G van der Kolk; Jaco J M Zwanenburg; Manon Brundel; Geert-Jan Biessels; Fredy Visser; Peter R Luijten; Jeroen Hendrikse Journal: Stroke Date: 2011-07-14 Impact factor: 7.914
Authors: Jinnan Wang; Michael Helle; Zechen Zhou; Peter Börnert; Thomas S Hatsukami; Chun Yuan Journal: Magn Reson Med Date: 2015-03-13 Impact factor: 4.668
Authors: Raghav R Mattay; Jose F Saucedo; Vance T Lehman; Jiayu Xiao; Emmanuel C Obusez; Scott B Raymond; Zhaoyang Fan; Jae W Song Journal: Semin Ultrasound CT MR Date: 2021-08-01 Impact factor: 1.641
Authors: B Sannananja; C Zhu; C G Colip; A Somasundaram; M Ibrahim; T Khrisat; M Mossa-Basha Journal: AJNR Am J Neuroradiol Date: 2022-05-26 Impact factor: 4.966
Authors: Jae W Song; Brianna F Moon; Morgan P Burke; Srikant Kamesh Iyer; Mark A Elliott; Haochang Shou; Steven R Messé; Scott E Kasner; Laurie A Loevner; Mitchell D Schnall; John E Kirsch; Walter R Witschey; Zhaoyang Fan Journal: J Neuroimaging Date: 2020-05-11 Impact factor: 2.486
Authors: Jiayu Xiao; Matthew M Padrick; Tao Jiang; Shuang Xia; Fang Wu; Yu Guo; Nestor R Gonzalez; Shujuan Li; Konrad H Schlick; Oana M Dumitrascu; Marcel M Maya; Marcio A Diniz; Shlee S Song; Patrick D Lyden; Debiao Li; Qi Yang; Zhaoyang Fan Journal: Atherosclerosis Date: 2021-01-11 Impact factor: 5.162
Authors: Jiayu Xiao; Shlee S Song; Konrad H Schlick; Shuang Xia; Tao Jiang; Tong Han; Robert J Jackson; Marcio A Diniz; Oana M Dumitrascu; Marcel M Maya; Patrick D Lyden; Debiao Li; Qi Yang; Zhaoyang Fan Journal: Neuroradiol J Date: 2021-06-23