OBJECTIVE: Recently, the technique of high-resolution magnetic resonance imaging (HR-MRI) has been developed to depict intracranial artery wall. We aimed to compare the vessel wall properties between symptomatic and asymptomatic atherosclerotic middle cerebral arteries (MCA) using HR-MRI. METHODS: We studied 26 patients with symptomatic and 35 patients with asymptomatic MCA stenosis. Routine cranial MRI, magnetic resonance angiography and HR-MRI were performed on each patient. The cross-sectional images of MCA wall on HR-MRI were compared between the two groups. RESULTS: The degree of MCA stenosis was similar between the two groups (67.9% vs 63.9%, P=0.327). On HR-MRI, eccentric plaques were observed in 26 (100%) symptomatic and 28 (80%) asymptomatic stenosis. In the remaining seven (20%) asymptomatic stenosis, only constrictive remodeling (vessel shrinkage) was observed. Compared with the asymptomatic group, symptomatic MCA stenosis had a larger wall area (P<0.001), greater remodeling ratio (P<0.001), higher prevalence of expansive remodeling (outward expansion of the vessel wall) (P=0.003) and lower prevalence of constrictive remodeling (P=0.008). CONCLUSIONS: Different vessel wall properties on HR-MRI were observed between symptomatic and asymptomatic MCA stenosis. Further prospective studies are required to investigate whether HR-MRI is a helpful tool in stratifying stroke risk in patients with MCA atherosclerotic disease.
OBJECTIVE: Recently, the technique of high-resolution magnetic resonance imaging (HR-MRI) has been developed to depict intracranial artery wall. We aimed to compare the vessel wall properties between symptomatic and asymptomatic atherosclerotic middle cerebral arteries (MCA) using HR-MRI. METHODS: We studied 26 patients with symptomatic and 35 patients with asymptomatic MCA stenosis. Routine cranial MRI, magnetic resonance angiography and HR-MRI were performed on each patient. The cross-sectional images of MCA wall on HR-MRI were compared between the two groups. RESULTS: The degree of MCA stenosis was similar between the two groups (67.9% vs 63.9%, P=0.327). On HR-MRI, eccentric plaques were observed in 26 (100%) symptomatic and 28 (80%) asymptomatic stenosis. In the remaining seven (20%) asymptomatic stenosis, only constrictive remodeling (vessel shrinkage) was observed. Compared with the asymptomatic group, symptomatic MCA stenosis had a larger wall area (P<0.001), greater remodeling ratio (P<0.001), higher prevalence of expansive remodeling (outward expansion of the vessel wall) (P=0.003) and lower prevalence of constrictive remodeling (P=0.008). CONCLUSIONS: Different vessel wall properties on HR-MRI were observed between symptomatic and asymptomatic MCA stenosis. Further prospective studies are required to investigate whether HR-MRI is a helpful tool in stratifying stroke risk in patients with MCA atherosclerotic disease.
Authors: Jose Gutierrez; Tatjana Rundek; Ken Cheung; Ahmet Bagci; Noam Alperin; Ralph L Sacco; Clinton B Wright; Mitchell S V Elkind; Marco R Di Tullio Journal: Cerebrovasc Dis Date: 2017-01-04 Impact factor: 2.762
Authors: Ji Eun Park; Seung Chai Jung; Sang Hun Lee; Ji Young Jeon; Ji Ye Lee; Ho Sung Kim; Choong-Gon Choi; Sang Joon Kim; Deok Hee Lee; Seon-Ok Kim; Sun U Kwon; Dong-Wha Kang; Jong S Kim Journal: Eur Radiol Date: 2017-05-12 Impact factor: 5.315
Authors: Petrice M Cogswell; Taylor L Davis; Megan K Strother; Carlos C Faraco; Allison O Scott; Lori C Jordan; Matthew R Fusco; Blaise deB Frederick; Jeroen Hendrikse; Manus J Donahue Journal: J Magn Reson Imaging Date: 2017-01-06 Impact factor: 4.813
Authors: D M Mandell; M Mossa-Basha; Y Qiao; C P Hess; F Hui; C Matouk; M H Johnson; M J A P Daemen; A Vossough; M Edjlali; D Saloner; S A Ansari; B A Wasserman; D J Mikulis Journal: AJNR Am J Neuroradiol Date: 2016-07-28 Impact factor: 3.825