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Literature DB >> 28105699

NEAT1: A novel cancer-related long non-coding RNA.

Xin Yu¹, Zheng Li², Heyi Zheng¹, Matthew T V Chan³, William Ka Kei Wu^3,4.

Abstract

Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1. Further investigations are warranted to elucidate the upstream and downstream mechanisms of NEAT1 overexpression.

Entities: Disease Gene

Mesh：

Substances：

Year: 2017 PMID： 28105699 PMCID： PMC6529067 DOI： 10.1111/cpr.12329

Source DB: PubMed Journal: Cell Prolif ISSN： 0960-7722 Impact factor: 6.831

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Authors: U M Sreenivasa Murthy; Pundi N Rangarajan
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Review 6. MicroRNAs predict and modulate responses to chemotherapy in colorectal cancer.

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7. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer.

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8. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer.

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9. The long noncoding RNA Neat1 is required for mammary gland development and lactation.

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Review 4. NEAT1: A novel cancer-related long non-coding RNA.

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7. Long non-coding RNA LINC00152 acts as a sponge of miRNA-193b-3p to promote tongue squamous cell carcinoma progression.

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