Literature DB >> 28105272

Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach.

Arno Vermote1, Gilles Brackman2, Martijn D P Risseeuw1, Davie Cappoen3, Paul Cos3, Tom Coenye2, Serge Van Calenbergh1.   

Abstract

A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward Staphylococcus aureus biofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC50 value of 0.26 μM.

Entities:  

Keywords:  Antibiotic potentiators; Staphylococcus aureus; biofilms; hamamelitannin analogues; quorum sensing

Year:  2016        PMID： 28105272      PMCID： PMC5238489          DOI： 10.1021/acsmedchemlett.6b00315

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  13 in total

Review 1.  Bacterial biofilms: a common cause of persistent infections.

Authors:  J W Costerton; P S Stewart; E P Greenberg
Journal:  Science       Date:  1999-05-21       Impact factor: 47.728

2.  Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.

Authors:  Gilles Brackman; Paul Cos; Louis Maes; Hans J Nelis; Tom Coenye
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

Review 3.  Adjuvant strategies for potentiation of antibiotics to overcome antimicrobial resistance.

Authors:  Michel Pieren; Marcel Tigges
Journal:  Curr Opin Pharmacol       Date:  2012-07-25       Impact factor: 5.547

4.  Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections.

Authors:  Arno Vermote; Gilles Brackman; Martijn D P Risseeuw; Tom Coenye; Serge Van Calenbergh
Journal:  Bioorg Med Chem       Date:  2016-07-28       Impact factor: 3.641

Review 5.  Vancomycin-intermediate resistance in Staphylococcus aureus.

Authors:  Keiichi Hiramatsu; Yuki Kayayama; Miki Matsuo; Yoshifumi Aiba; Michie Saito; Tomomi Hishinuma; Akira Iwamoto
Journal:  J Glob Antimicrob Resist       Date:  2014-06-07       Impact factor: 4.035

Review 6.  New approaches for treating staphylococcal biofilm infections.

Authors:  Megan R Kiedrowski; Alexander R Horswill
Journal:  Ann N Y Acad Sci       Date:  2011-12       Impact factor: 5.691

Review 7.  Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.

Authors:  Steven Y C Tong; Joshua S Davis; Emily Eichenberger; Thomas L Holland; Vance G Fowler
Journal:  Clin Microbiol Rev       Date:  2015-07       Impact factor: 26.132

Review 8.  Combination approaches to combat multidrug-resistant bacteria.

Authors:  Roberta J Worthington; Christian Melander
Journal:  Trends Biotechnol       Date:  2013-01-18       Impact factor: 19.536

9.  Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus.

Authors:  Arno Vermote; Gilles Brackman; Martijn D P Risseeuw; Bieke Vanhoutte; Paul Cos; Kristof Van Hecke; Koen Breyne; Evelyne Meyer; Tom Coenye; Serge Van Calenbergh
Journal:  Angew Chem Int Ed Engl       Date:  2016-04-20       Impact factor: 15.336

10.  Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening.

Authors:  Madanahally D Kiran; Nallini Vijayarangan Adikesavan; Oscar Cirioni; Andrea Giacometti; Carmela Silvestri; Giorgio Scalise; Roberto Ghiselli; Vittorio Saba; Fiorenza Orlando; Menachem Shoham; Naomi Balaban
Journal:  Mol Pharmacol       Date:  2008-02-26       Impact factor: 4.436
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  4 in total

1.  Natural products as inspiration for the development of bacterial antibiofilm agents.

Authors:  Roberta J Melander; Akash K Basak; Christian Melander
Journal:  Nat Prod Rep       Date:  2020-07-01       Impact factor: 13.423

2.  Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus.

Authors:  Jakob Bouton; Kristof Van Hecke; Reuven Rasooly; Serge Van Calenbergh
Journal:  Beilstein J Org Chem       Date:  2018-11-12       Impact factor: 2.883

3.  PEGylation of Polyethylenimine Lowers Acute Toxicity while Retaining Anti-Biofilm and β-Lactam Potentiation Properties against Antibiotic-Resistant Pathogens.

Authors:  Anh K Lam; Erika L Moen; Jennifer Pusavat; Cassandra L Wouters; Hannah Panlilio; Maya J Ferrell; Matthew B Houck; Daniel T Glatzhofer; Charles V Rice
Journal:  ACS Omega       Date:  2020-09-29

Review 4.  Methicillin-resistant Staphylococcus aureus as a cause of chronic wound infections: Alternative strategies for management.

Authors:  Oriana Simonetti; Samuele Marasca; Matteo Candelora; Giulio Rizzetto; Giulia Radi; Elisa Molinelli; Lucia Brescini; Oscar Cirioni; Annamaria Offidani
Journal:  AIMS Microbiol       Date:  2022-04-24
  4 in total

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