| Literature DB >> 27873679 |
Keiichi Hiramatsu1, Yuki Kayayama2, Miki Matsuo2, Yoshifumi Aiba2, Michie Saito2, Tomomi Hishinuma2, Akira Iwamoto2.
Abstract
Vancomycin-intermediate Staphylococcus aureus (VISA) and its precursor hetero-VISA (hVISA) were discovered almost 20 years ago and have continued to be a stumbling block in the chemotherapy of methicillin-resistant S. aureus (MRSA). Unlike vancomycin resistance mediated by the van gene in enterococci and staphylococci, VISA is generated by accumulation of mutations. It displays diverse and intriguing genetic mechanisms underlying its resistance phenotype. Here we make a brief note on our recent understanding of the genetics of hVISA, VISA and the newly discovered phenotype 'slow VISA' (sVISA). Copyright ÂEntities:
Keywords: Pre-hVISA; VISA; Vancomycin; hVISA; rpoB mutation; sVISA
Year: 2014 PMID: 27873679 DOI: 10.1016/j.jgar.2014.04.006
Source DB: PubMed Journal: J Glob Antimicrob Resist ISSN: 2213-7165 Impact factor: 4.035