| Literature DB >> 27095479 |
Arno Vermote1, Gilles Brackman2, Martijn D P Risseeuw1, Bieke Vanhoutte3, Paul Cos3, Kristof Van Hecke4, Koen Breyne5, Evelyne Meyer5, Tom Coenye2, Serge Van Calenbergh6,6.
Abstract
The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.Entities:
Keywords: MRSA; antibiotics; biofilms; potentiators; quorum sensing
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Year: 2016 PMID： 27095479 DOI： 10.1002/anie.201601973
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336