Literature DB >> 28102760

PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.

Alisa Fuchs1, Marcos Torroba1, Sarah Kinkley1.   

Abstract

We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.

Entities:  

Keywords:  PHF13; RNA polymerase II; RNA polymerase II pausing; SPOC1; bivalency and H3K4me3; co-transcriptional splicing; polycomb repressive complex 2 (PRC2); transcriptional regulation

Mesh：

Substances：

Year:  2017        PMID： 28102760      PMCID： PMC5423499          DOI： 10.1080/21541264.2016.1274813

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  39 in total

1.  Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons.

Authors:  Sahar Gelfman; David Burstein; Osnat Penn; Anna Savchenko; Maayan Amit; Schraga Schwartz; Tal Pupko; Gil Ast
Journal:  Genome Res       Date:  2011-10-05       Impact factor: 9.043

2.  Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.

Authors:  Robert J Sims; Scott Millhouse; Chi-Fu Chen; Brian A Lewis; Hediye Erdjument-Bromage; Paul Tempst; James L Manley; Danny Reinberg
Journal:  Mol Cell       Date:  2007-11-30       Impact factor: 17.970

Review 3.  Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.

Authors:  Tassa Saldi; Michael A Cortazar; Ryan M Sheridan; David L Bentley
Journal:  J Mol Biol       Date:  2016-04-20       Impact factor: 5.469

4.  Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

Authors:  M L West; J L Corden
Journal:  Genetics       Date:  1995-08       Impact factor: 4.562

5.  KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

Authors:  Ryan P McNamara; Jonathan E Reeder; Elizabeth A McMillan; Curtis W Bacon; Jennifer L McCann; Iván D'Orso
Journal:  Mol Cell       Date:  2015-12-24       Impact factor: 17.970

Review 6.  Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription.

Authors:  Martin Heidemann; Corinna Hintermair; Kirsten Voß; Dirk Eick
Journal:  Biochim Biophys Acta       Date:  2012-09-07

7.  Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.

Authors:  Feng Tie; Rakhee Banerjee; Chen Fu; Carl A Stratton; Ming Fang; Peter J Harte
Journal:  Proc Natl Acad Sci U S A       Date:  2016-01-22       Impact factor: 11.205

8.  Splicing-dependent RNA polymerase pausing in yeast.

Authors:  Ross D Alexander; Steven A Innocente; J David Barrass; Jean D Beggs
Journal:  Mol Cell       Date:  2010-11-24       Impact factor: 19.328

9.  Chd1 co-localizes with early transcription elongation factors independently of H3K36 methylation and releases stalled RNA polymerase II at introns.

Authors:  Daechan Park; Haridha Shivram; Vishwanath R Iyer
Journal:  Epigenetics Chromatin       Date:  2014-10-27       Impact factor: 4.954

10.  TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.

Authors:  Heeyoun Bunch; Xiaofeng Zheng; Adam Burkholder; Simon T Dillon; Shmulik Motola; Gabriel Birrane; Christopher C Ebmeier; Stuart Levine; David Fargo; Guang Hu; Dylan J Taatjes; Stuart K Calderwood
Journal:  Nat Struct Mol Biol       Date:  2014-08-31       Impact factor: 15.369
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  2 in total

1.  PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition.

Authors:  Yating Sun; Dan Li; Hongmei Liu; Yongye Huang; Fanyu Meng; Jiahao Tang; Zhanjun Li; Wanhua Xie
Journal:  Cell Death Dis       Date:  2022-05-21       Impact factor: 9.685

2.  Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication.

Authors:  Stephan Hofmann; Sandra Dehn; Ramona Businger; Sebastian Bolduan; Martha Schneider; Zeger Debyser; Ruth Brack-Werner; Michael Schindler
Journal:  Open Biol       Date:  2017-10       Impact factor: 6.411
  2 in total

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