Literature DB >> 28102758

P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II.

You Li1, Min Liu1, Lin-Feng Chen2, Ruichuan Chen1.   

Abstract

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

Entities:  

Keywords:  7SK snRNP; Brd4; KAP1; P-TEFb; RNA Pol II; SEC; promoter-proximal pausing; transcription elongation

Mesh：

Substances：

Year:  2018        PMID： 28102758      PMCID： PMC5834220          DOI： 10.1080/21541264.2017.1281864

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  31 in total

1.  Control of formation of two distinct classes of RNA polymerase II elongation complexes.

Authors:  N F Marshall; D H Price
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

2.  Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.

Authors:  Bo Huang; Xiao-Dong Yang; Ming-Ming Zhou; Keiko Ozato; Lin-Feng Chen
Journal:  Mol Cell Biol       Date:  2008-12-22       Impact factor: 4.272

Review 3.  The super elongation complex (SEC) family in transcriptional control.

Authors:  Zhuojuan Luo; Chengqi Lin; Ali Shilatifard
Journal:  Nat Rev Mol Cell Biol       Date:  2012-08-16       Impact factor: 94.444

Review 4.  RNA polymerase II pausing during development.

Authors:  Bjoern Gaertner; Julia Zeitlinger
Journal:  Development       Date:  2014-03       Impact factor: 6.868

5.  KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

Authors:  Ryan P McNamara; Jonathan E Reeder; Elizabeth A McMillan; Curtis W Bacon; Jennifer L McCann; Iván D'Orso
Journal:  Mol Cell       Date:  2015-12-24       Impact factor: 17.970

6.  DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.

Authors:  T Wada; T Takagi; Y Yamaguchi; A Ferdous; T Imai; S Hirose; S Sugimoto; K Yano; G A Hartzog; F Winston; S Buratowski; H Handa
Journal:  Genes Dev       Date:  1998-02-01       Impact factor: 11.361

7.  Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.

Authors:  Xiangming Hu; Xiaodong Lu; Runzhong Liu; Nanping Ai; Zhenhua Cao; Yannan Li; Jiangfang Liu; Bin Yu; Kai Liu; Huiping Wang; Chao Zhou; Yu Wang; Aidong Han; Feng Ding; Ruichuan Chen
Journal:  J Biol Chem       Date:  2014-06-17       Impact factor: 5.157

8.  PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.

Authors:  Swapna Aravind Gudipaty; Ryan P McNamara; Emily L Morton; Iván D'Orso
Journal:  Mol Cell Biol       Date:  2015-08-31       Impact factor: 4.272

9.  Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

Authors:  Wen Liu; Qi Ma; Kaki Wong; Wenbo Li; Kenny Ohgi; Jie Zhang; Aneel Aggarwal; Michael G Rosenfeld
Journal:  Cell       Date:  2013-12-19       Impact factor: 41.582

10.  Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.

Authors:  Xiaodong Lu; Xinxing Zhu; You Li; Min Liu; Bin Yu; Yu Wang; Muhua Rao; Haiyang Yang; Kai Zhou; Yao Wang; Yanheng Chen; Meihua Chen; Songkuan Zhuang; Lin-Feng Chen; Runzhong Liu; Ruichuan Chen
Journal:  Nucleic Acids Res       Date:  2016-06-28       Impact factor: 16.971
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  21 in total

Review 1.  Hexim1, an RNA-controlled protein hub.

Authors:  Annemieke A Michels; Olivier Bensaude
Journal:  Transcription       Date:  2018-02-23

2.  Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors.

Authors:  Ryan D Martin; Yalin Sun; Sarah MacKinnon; Luca Cuccia; Viviane Pagé; Terence E Hébert; Jason C Tanny
Journal:  Mol Cell Biol       Date:  2020-06-29       Impact factor: 4.272

3.  Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism.

Authors:  Daniele Hasler; Gunter Meister; Utz Fischer
Journal:  RNA Biol       Date:  2020-06-03       Impact factor: 4.652

Review 4.  Organization and regulation of gene transcription.

Authors:  Patrick Cramer
Journal:  Nature       Date:  2019-08-28       Impact factor: 49.962

Review 5.  The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.

Authors:  Sean Paz; Anastasia Ritchie; Christopher Mauer; Massimo Caputi
Journal:  Cytokine Growth Factor Rev       Date:  2020-11-02       Impact factor: 7.638

6.  Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate.

Authors:  Matthieu D Lavigne; Dimitris Konstantopoulos; Katerina Z Ntakou-Zamplara; Anastasios Liakos; Maria Fousteri
Journal:  Nat Commun       Date:  2017-12-12       Impact factor: 14.919

7.  de novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation.

Authors:  Pauline E Schneeberger; Tatjana Bierhals; Axel Neu; Maja Hempel; Kerstin Kutsche
Journal:  Sci Rep       Date:  2019-08-29       Impact factor: 4.379

Review 8.  Dysregulated Transcriptional Control in Prostate Cancer.

Authors:  Simon J Baumgart; Ekaterina Nevedomskaya; Bernard Haendler
Journal:  Int J Mol Sci       Date:  2019-06-13       Impact factor: 5.923

9.  The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.

Authors:  Michael J Jurynec; Xiaoying Bai; Brent W Bisgrove; Haley Jackson; Alex Nechiporuk; Rebecca A S Palu; Hannah A Grunwald; Yi-Chu Su; Kazuyuki Hoshijima; H Joseph Yost; Leonard I Zon; David Jonah Grunwald
Journal:  Development       Date:  2019-12-16       Impact factor: 6.868

10.  ARS2 is a general suppressor of pervasive transcription.

Authors:  Claudia Iasillo; Manfred Schmid; Yousra Yahia; Muhammad A Maqbool; Nicolas Descostes; Evdoxia Karadoulama; Edouard Bertrand; Jean-Christophe Andrau; Torben Heick Jensen
Journal:  Nucleic Acids Res       Date:  2017-09-29       Impact factor: 16.971
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