Literature DB >> 28096180

Nutrient sensing and TOR signaling in yeast and mammals.

Asier González1, Michael N Hall2.   

Abstract

Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases.
© 2017 The Authors.

Entities:  

Keywords:  zzm321990RAGzzm321990; TORC1; amino acids; glucose; mammals; nutrients; yeast

Mesh：

Substances：

Year:  2017        PMID： 28096180      PMCID： PMC5694944          DOI： 10.15252/embj.201696010

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  162 in total

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Journal:  J Biol Chem       Date:  2001-03-26       Impact factor: 5.157

Review 2.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

3.  Regulation of transcription factor latency by receptor-activated proteolysis.

Authors:  Claes Andréasson; Stijn Heessen; Per O Ljungdahl
Journal:  Genes Dev       Date:  2006-06-15       Impact factor: 11.361

4.  AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

Authors:  Ya-Lin Zhang; Huiling Guo; Chen-Song Zhang; Shu-Yong Lin; Zhenyu Yin; Yongying Peng; Hui Luo; Yuzhe Shi; Guili Lian; Cixiong Zhang; Mengqi Li; Zhiyun Ye; Jing Ye; Jiahuai Han; Peng Li; Jia-Wei Wu; Sheng-Cai Lin
Journal:  Cell Metab       Date:  2013-10-01       Impact factor: 27.287

Review 5.  Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

Authors:  Jun Hee Lee; Uhn-Soo Cho; Michael Karin
Journal:  Sci Signal       Date:  2016-06-07       Impact factor: 8.192

Review 6.  Sestrins orchestrate cellular metabolism to attenuate aging.

Authors:  Jun Hee Lee; Andrei V Budanov; Michael Karin
Journal:  Cell Metab       Date:  2013-09-19       Impact factor: 27.287

7.  Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.

Authors:  Julien Averous; Alain Bruhat; Céline Jousse; Valérie Carraro; Gerald Thiel; Pierre Fafournoux
Journal:  J Biol Chem       Date:  2003-12-01       Impact factor: 5.157

8.  A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Authors:  Liron Bar-Peled; Lynne Chantranupong; Andrew D Cherniack; Walter W Chen; Kathleen A Ottina; Brian C Grabiner; Eric D Spear; Scott L Carter; Matthew Meyerson; David M Sabatini
Journal:  Science       Date:  2013-05-31       Impact factor: 47.728

9.  Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

Authors:  Vera A Cherkasova; Alan G Hinnebusch
Journal:  Genes Dev       Date:  2003-03-21       Impact factor: 11.361

10.  Lysosomal recruitment of TSC2 is a universal response to cellular stress.

Authors:  Constantinos Demetriades; Monika Plescher; Aurelio A Teleman
Journal:  Nat Commun       Date:  2016-02-12       Impact factor: 14.919
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  239 in total

1.  Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids.

Authors:  Maria A Frias; Suman Mukhopadhyay; Elyssa Lehman; Aleksandra Walasek; Matthew Utter; Deepak Menon; David A Foster
Journal:  J Biol Chem       Date:  2019-11-24       Impact factor: 5.157

2.  Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry.

Authors:  Peter L Freddolino; Jamie Yang; Amir Momen-Roknabadi; Saeed Tavazoie
Journal:  Elife       Date:  2018-04-05       Impact factor: 8.140

3.  Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments.

Authors:  Christopher A Jackson; Dayanne M Castro; Richard Bonneau; David Gresham; Giuseppe-Antonio Saldi
Journal:  Elife       Date:  2020-01-27       Impact factor: 8.140

4.  A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis.

Authors:  Ritu Gupta; Adhish S Walvekar; Shun Liang; Zeenat Rashida; Premal Shah; Sunil Laxman
Journal:  Elife       Date:  2019-07-01       Impact factor: 8.140

Review 5.  Integration of nutrient, energy, light, and hormone signalling via TOR in plants.

Authors:  Yue Wu; Lin Shi; Lei Li; Liwen Fu; Yanlin Liu; Yan Xiong; Jen Sheen
Journal:  J Exp Bot       Date:  2019-04-15       Impact factor: 6.992

Review 6.  LARP1 on TOP of ribosome production.

Authors:  Bruno D Fonseca; Roni M Lahr; Christian K Damgaard; Tommy Alain; Andrea J Berman
Journal:  Wiley Interdiscip Rev RNA       Date:  2018-05-02       Impact factor: 9.957

7.  Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Authors:  Joshua D Ochocki; Sanika Khare; Markus Hess; Daniel Ackerman; Bo Qiu; Jennie I Daisak; Andrew J Worth; Nan Lin; Pearl Lee; Hong Xie; Bo Li; Bradley Wubbenhorst; Tobi G Maguire; Katherine L Nathanson; James C Alwine; Ian A Blair; Itzhak Nissim; Brian Keith; M Celeste Simon
Journal:  Cell Metab       Date:  2018-05-10       Impact factor: 27.287

Review 8.  Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway.

Authors:  R Nicholas Laribee
Journal:  J Mol Biol       Date:  2018-10-23       Impact factor: 5.469

Review 9.  Whi2: a new player in amino acid sensing.

Authors:  Xinchen Teng; J Marie Hardwick
Journal:  Curr Genet       Date:  2019-01-30       Impact factor: 3.886

10.  Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

Authors:  Sathish K R Padi; Neha Singh; Jeremiah J Bearss; Virginie Olive; Jin H Song; Marina Cardó-Vila; Andrew S Kraft; Koichi Okumura
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-23       Impact factor: 11.205
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