Giuseppe Bruschi1, Alessandro Maloberti2,3, Paola Sormani2,3, Giulia Colombo2,3, Stefano Nava1, Paola Vallerio3, Francesca Casadei3, Jolie Bruno2, Antonella Moreo3, Bruno Merlanti4, Claudio Russo4, Fabrizio Oliva1, Silvio Klugmann1, Cristina Giannattasio5,6. 1. Cardiology I, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy. 2. Health Science Department, Milano-Bicocca University, Milan, Italy. 3. Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy. 4. Cardiosurgery, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy. 5. Health Science Department, Milano-Bicocca University, Milan, Italy. cristina.giannattasio@unimib.it. 6. Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy. cristina.giannattasio@unimib.it.
Abstract
INTRODUCTION: Aortic stenosis (AS) is more than only a degenerative disease, it could be also an atherosclerotic-like process involving the valve instead of the vessels. Little is known about the relation of arterial stiffness and AS. AIM: We sought to determine wether pulse wave velocity (PWV), is related to AS severity and to the procedures response, both as surgical aortic-valve-replacement (AVR) and trascatheter-aortic-valve-implantation (TAVI). METHODS: 30 patients with severe AS were treated (15 AVR, 15 TAVI). Before the procedures (t0) and after 1 week (t1) echocardiography and PWV were evaluated. RESULTS: On the whole population, subjects with higher PWV showed higher transvalvular pressure gradient at baseline (mean: 56.5 ± 15.1 vs 45.4 ± 9.5; peak: 93.3 ± 26.4 vs 73.3 ± 14.9, p = 0.02) and, a significantly greater response to the procedures (mean: -42.9 ± 17.2 vs -27.9 ± 10.1, peak: -68.7 ± 29.2 vs -42.8 ± 16.4, p = 0.02). When the two different procedures groups were separated, data were confirmed only in the TAVI subgroup. CONCLUSIONS: In patients undergoing procedures for AS, PWV is correlated with transvalvular gradient and, in TAVI subjects, is able to predict the echocardiographic response. Baseline evaluation of PWV in patients candidates to TAVI can help the selection of subjects, even if larger and longer studies are needed before definitive conclusion can be drawn.
INTRODUCTION:Aortic stenosis (AS) is more than only a degenerative disease, it could be also an atherosclerotic-like process involving the valve instead of the vessels. Little is known about the relation of arterial stiffness and AS. AIM: We sought to determine wether pulse wave velocity (PWV), is related to AS severity and to the procedures response, both as surgical aortic-valve-replacement (AVR) and trascatheter-aortic-valve-implantation (TAVI). METHODS: 30 patients with severe AS were treated (15 AVR, 15 TAVI). Before the procedures (t0) and after 1 week (t1) echocardiography and PWV were evaluated. RESULTS: On the whole population, subjects with higher PWV showed higher transvalvular pressure gradient at baseline (mean: 56.5 ± 15.1 vs 45.4 ± 9.5; peak: 93.3 ± 26.4 vs 73.3 ± 14.9, p = 0.02) and, a significantly greater response to the procedures (mean: -42.9 ± 17.2 vs -27.9 ± 10.1, peak: -68.7 ± 29.2 vs -42.8 ± 16.4, p = 0.02). When the two different procedures groups were separated, data were confirmed only in the TAVI subgroup. CONCLUSIONS: In patients undergoing procedures for AS, PWV is correlated with transvalvular gradient and, in TAVI subjects, is able to predict the echocardiographic response. Baseline evaluation of PWV in patients candidates to TAVI can help the selection of subjects, even if larger and longer studies are needed before definitive conclusion can be drawn.
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