Yuya Koike1, Seishi Matsui2, Masao Omura3, Kohzoh Makita4, Alfonso W D Obara5, Nobukazu Moriya5, Tetsuo Nishikawa3. 1. Department of Interventional Radiology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kouhoku-Ku, Yokohama, Kanagawa, 222-0036, Japan. r06118@hotmail.co.jp. 2. Department of Interventional Radiology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kouhoku-Ku, Yokohama, Kanagawa, 222-0036, Japan. 3. Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan. 4. Department of Radiology, Nerima Hikarigaoka Hospital, Tokyo, Japan. 5. Department of Radiology, Yokohama Rosai Hospital, Yokohama, Japan.
Abstract
OBJECTIVE: A stress reaction involving increased adrenal hormone release occurs when starting adrenal venous sampling (AVS). The purpose of the present study was to investigate the effect of single shot venography on adrenal hormone production during AVS. SUBJECTS AND METHODS: This was a prospective self-controlled study. We enrolled 54 consecutive patients (21 men, 33 women; mean age 52 ± 11 years) with primary aldosteronism who underwent AVS from May 2014 to February 2015. Under non-stimulated conditions, blood samples were obtained from a common trunk of the left adrenal vein before and after single shot venography. The initial plasma aldosterone and cortisol concentration (PAC and PCC) were compared with those measured after venography for each patient. RESULTS: PAC and PCC were slightly but significantly decreased between before and after venography (after log transformation 2.12 ± 0.73 vs 2.07 ± 0.72, P = 0.00066, 1.89 ± 0.52 vs 1.83 ± 0.53, P = 0.00031, respectively). CONCLUSIONS: During non-stimulated left AVS, adrenal hormone secretion was slightly but significantly decreased after venography, similar to the normal time-related stress reaction. Venography did not increase the adrenal hormone secretion.
OBJECTIVE: A stress reaction involving increased adrenal hormone release occurs when starting adrenal venous sampling (AVS). The purpose of the present study was to investigate the effect of single shot venography on adrenal hormone production during AVS. SUBJECTS AND METHODS: This was a prospective self-controlled study. We enrolled 54 consecutive patients (21 men, 33 women; mean age 52 ± 11 years) with primary aldosteronism who underwent AVS from May 2014 to February 2015. Under non-stimulated conditions, blood samples were obtained from a common trunk of the left adrenal vein before and after single shot venography. The initial plasma aldosterone and cortisol concentration (PAC and PCC) were compared with those measured after venography for each patient. RESULTS: PAC and PCC were slightly but significantly decreased between before and after venography (after log transformation 2.12 ± 0.73 vs 2.07 ± 0.72, P = 0.00066, 1.89 ± 0.52 vs 1.83 ± 0.53, P = 0.00031, respectively). CONCLUSIONS: During non-stimulated left AVS, adrenal hormone secretion was slightly but significantly decreased after venography, similar to the normal time-related stress reaction. Venography did not increase the adrenal hormone secretion.
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