Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 MraY-antibiotic complex reveals details of tunicamycin mode of action.

Literature DB >> 28068312

MraY-antibiotic complex reveals details of tunicamycin mode of action.

Jonna K Hakulinen¹, Jenny Hering^1,2, Gisela Brändén², Hongming Chen¹, Arjan Snijder¹, Margareta Ek¹, Patrik Johansson¹.

Abstract

The rapid increase of antibiotic resistance has created an urgent need to develop novel antimicrobial agents. Here we describe the crystal structure of the promising bacterial target phospho-N-acetylmuramoyl-pentapeptide translocase (MraY) in complex with the nucleoside antibiotic tunicamycin. The structure not only reveals the mode of action of several related natural-product antibiotics but also gives an indication on the binding mode of the MraY UDP-MurNAc-pentapeptide and undecaprenyl-phosphate substrates.

Entities: Chemical

Mesh：

Substances：

Year: 2017 PMID： 28068312 DOI： 10.1038/nchembio.2270

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

27 in total

1. Conserved cytoplasmic motifs that distinguish sub-groups of the polyprenol phosphate:N-acetylhexosamine-1-phosphate transferase family.

Authors: M S Anderson; S S Eveland; N P Price
Journal: FEMS Microbiol Lett Date: 2000-10-15 Impact factor: 2.742

2. EVIDENCE FOR AN INITIAL ACCEPTOR OF UDP-NAC-MURAMYL-PENTAPEPTIDE IN THE SYNTHESIS OF BACTERIAL MUCOPEPTIDE.

Authors: W G STRUVE; F C NEUHAUS
Journal: Biochem Biophys Res Commun Date: 1965-01-04 Impact factor: 3.575

3. Diffraction cartography: applying microbeams to macromolecular crystallography sample evaluation and data collection.

Authors: Matthew W Bowler; Matias Guijarro; Sebastien Petitdemange; Isabel Baker; Olof Svensson; Manfred Burghammer; Christoph Mueller-Dieckmann; Elspeth J Gordon; David Flot; Sean M McSweeney; Gordon A Leonard
Journal: Acta Crystallogr D Biol Crystallogr Date: 2010-07-09

4. Fluorescent probe for high-throughput screening of membrane protein expression.

Authors: A E Backmark; N Olivier; A Snijder; E Gordon; N Dekker; A D Ferguson
Journal: Protein Sci Date: 2013-07-03 Impact factor: 6.725

5. A modular approach to the total synthesis of tunicamycins.

Authors: Jiakun Li; Biao Yu
Journal: Angew Chem Int Ed Engl Date: 2015-04-14 Impact factor: 15.336

6. [27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

Authors: Eric de La Fortelle; Gérard Bricogne
Journal: Methods Enzymol Date: 1997 Impact factor: 1.600

7. Solubilization and properties of mannose and N-acetylglucosamine transferases involved in formation of polyprenyl-sugar intermediates.

Authors: A Heifetz; A D Elbein
Journal: J Biol Chem Date: 1977-05-10 Impact factor: 5.157

8. Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates.

Authors: Filip J Wyszynski; Seung Seo Lee; Tomoaki Yabe; Hua Wang; Juan Pablo Gomez-Escribano; Mervyn J Bibb; Soo Jae Lee; Gideon J Davies; Benjamin G Davis
Journal: Nat Chem Date: 2012-05-20 Impact factor: 24.427

9. Fitting molecular fragments into electron density.

Authors: Kevin Cowtan
Journal: Acta Crystallogr D Biol Crystallogr Date: 2007-12-05

10. Phaser crystallographic software.

Authors: Airlie J McCoy; Ralf W Grosse-Kunstleve; Paul D Adams; Martyn D Winn; Laurent C Storoni; Randy J Read
Journal: J Appl Crystallogr Date: 2007-07-13 Impact factor: 3.304

29 in total

1. Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors.

Authors: Neil Pj Price; Michael A Jackson; Karl E Vermillion; Judith A Blackburn; Jiakun Li; Biao Yu
Journal: J Antibiot (Tokyo) Date: 2017-11-01 Impact factor: 2.649

2. Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactams.

Authors: Neil Pj Price; Trina M Hartman; Jiakun Li; Kiran K Velpula; Todd A Naumann; Maheedhara R Guda; Biao Yu; Kenneth M Bischoff
Journal: J Antibiot (Tokyo) Date: 2017-09-27 Impact factor: 2.649

Review 3. Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.

Authors: David A Dik; Jed F Fisher; Shahriar Mobashery
Journal: Chem Rev Date: 2018-05-30 Impact factor: 60.622

4. Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

Authors: Stefan Koppermann; Zheng Cui; Patrick D Fischer; Xiachang Wang; Jannine Ludwig; Jon S Thorson; Steven G Van Lanen; Christian Ducho
Journal: ChemMedChem Date: 2018-03-23 Impact factor: 3.466

5. N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis.

Authors: Stanislav Huszár; Vinayak Singh; Alica Polčicová; Peter Baráth; María Belén Barrio; Sophie Lagrange; Véronique Leblanc; Carol A Nacy; Valerie Mizrahi; Katarína Mikušová
Journal: Antimicrob Agents Chemother Date: 2017-10-24 Impact factor: 5.191

Review 6. Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface.

Authors: Vinita Lukose; Marthe T C Walvoort; Barbara Imperiali
Journal: Glycobiology Date: 2017-09-01 Impact factor: 4.313

7. Peptidoglycan and Teichoic Acid Levels and Alterations in Staphylococcus aureus by Cell-Wall and Whole-Cell Nuclear Magnetic Resonance.

Authors: Joseph A H Romaniuk; Lynette Cegelski
Journal: Biochemistry Date: 2018-06-11 Impact factor: 3.162