Literature DB >> 28067926

Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents.

X Luo1, B Li1, X Zhang1, W Zhao1, A Bratasz2, B Deng3, D W McComb3, Y Dong1.   

Abstract

Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a comparable or a slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, a strong MRI signal was observed in the cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated an efficient delivery of mRNA and Gd contrast agents in vivo.

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Year:  2017        PMID： 28067926      PMCID： PMC5316423          DOI： 10.1039/c6nr08496f

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  36 in total

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