Literature DB >> 28066828

THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS.

Kenneth Blum1, B W Downs2, Kristina Dushaj3, Mona Li3, Eric R Braverman3, Lyle Fried4, Roger Waite5, Zsolt Demotrovics6, Rajendra D Badgaiyan7.   

Abstract

DNA Customization of nutraceutical products is here. In the truest sense, "Gene Guided Precision Nutrition™" and KB220 variants (a complex mixture of amino-acids, trace metals, and herbals) are the pioneers and standard-bearers for a state of the art DNA customization. Findings by both, Kenneth Blum, Ph.D. and Ernest Noble, Ph.D. concerning the role of genes in shaping cravings and pleasure- seeking, opened the doors to comprehension of how genetics control our actions and effect our mental and physical health. Moreover, technology that is related to KB220 variants in order to reduce or eradicate excessive cravings by influencing gene expression is a cornerstone in the pioneering of the practical applications of nutrigenomics. Continuing discoveries have been an important catalyst for the evolution, expansion, and scientific recognition of the significance of nutrigenomics and its remarkable contributions to human health. Neuro-Nutrigenomics is now a very important field of scientific investigation that offers great promise to improving the human condition. In the forefront is the development of the Genetic Addiction Risk Score (GARS™), which unlike 23andMe, has predictive value for the severity of drug and alcohol abuse as well as other non-substance related addictive behaviors. While customization of neuronutrients has not yet been commercialized, there is emerging evidence that in the future, the concept will be developed and could have a significant impact in addiction medicine.

Entities:  

Keywords:  DNA Customization; GARS; Nutraceuticals; Pro-Dopamine regulation (KB220 variants) Reward Deficiency Solution Sustem

Year:  2016        PMID: 28066828      PMCID: PMC5210211     

Source DB:  PubMed          Journal:  Precis Med (Bangalore)        ISSN: 2456-2254


  55 in total

1.  Overexpression of dopamine D2 receptors reduces alcohol self-administration.

Authors:  P K Thanos; N D Volkow; P Freimuth; H Umegaki; H Ikari; G Roth; D K Ingram; R Hitzemann
Journal:  J Neurochem       Date:  2001-09       Impact factor: 5.372

Review 2.  The genetics of problem and pathological gambling: a systematic review.

Authors:  Agoston Gyollai; Mark D Griffiths; Csaba Barta; Andrea Vereczkei; Róbert Urbán; Bernadette Kun; Gyöngyi Kökönyei; Anna Székely; Mária Sasvári-Székely; Kenneth Blum; Zsolt Demetrovics
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

Review 3.  New Dietary Supplements for Obesity: What We Currently Know.

Authors:  Alejandro Ríos-Hoyo; Gabriela Gutiérrez-Salmeán
Journal:  Curr Obes Rep       Date:  2016-06

4.  Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking.

Authors:  Panayotis K Thanos; Seth N Rivera; Katrina Weaver; David K Grandy; Marcelo Rubinstein; Hiroyuki Umegaki; Gene Jack Wang; Robert Hitzemann; Nora D Volkow
Journal:  Life Sci       Date:  2005-02-09       Impact factor: 5.037

5.  Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations.

Authors:  Ke Xu; Dirk Lichtermann; Robert H Lipsky; Petra Franke; Xiehe Liu; Ying Hu; Liping Cao; Sibylle G Schwab; Dieter B Wildenauer; Claiton H D Bau; Erica Ferro; Will Astor; Thembi Finch; Jeanietta Terry; Julie Taubman; Wolfgang Maier; David Goldman
Journal:  Arch Gen Psychiatry       Date:  2004-06

6.  Transcriptome organization for chronic alcohol abuse in human brain.

Authors:  S P Farris; D Arasappan; S Hunicke-Smith; R A Harris; R D Mayfield
Journal:  Mol Psychiatry       Date:  2014-12-02       Impact factor: 15.992

Review 7.  Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric.

Authors:  Kenneth Blum; Marcelo Febo; Thomas McLaughlin; Frans J Cronjé; David Han; S Mark Gold
Journal:  J Behav Addict       Date:  2014-08-26       Impact factor: 6.756

8.  Addiction Research and Therapy in the 21st Century: Providing a Forum for Evidence -Based Addiction Medicine.

Authors:  Kenneth Blum; Rajendra D Badgaiyan
Journal:  J Addict Res Ther       Date:  2013

9.  Genetic risk prediction and neurobiological understanding of alcoholism.

Authors:  D F Levey; H Le-Niculescu; J Frank; M Ayalew; N Jain; B Kirlin; R Learman; E Winiger; Z Rodd; A Shekhar; N Schork; F Kiefer; F Kiefe; N Wodarz; B Müller-Myhsok; N Dahmen; M Nöthen; R Sherva; L Farrer; A H Smith; H R Kranzler; M Rietschel; J Gelernter; A B Niculescu
Journal:  Transl Psychiatry       Date:  2014-05-20       Impact factor: 6.222

10.  Nutrigenomics and its Impact on Life Style Associated Metabolic Diseases.

Authors:  Shalika Rana; Shiv Kumar; Nikita Rathore; Yogendra Padwad; Shashi Bhushana
Journal:  Curr Genomics       Date:  2016-06       Impact factor: 2.236

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  10 in total

1.  Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

Authors:  Kenneth Blum; Edward J Modestino; Rajendra D Badgaiyan; David Baron; Panayotis K Thanos; Igor Elman; David Siwicki; Marcelo Febo; Mark S Gold
Journal:  EC Psychol Psychiatr       Date:  2018-07-30

2.  Insurance Companies Fighting the Peer Review Empire without any Validity: the Case for Addiction and Pain Modalities in the face of an American Drug Epidemic.

Authors:  K Blum; W Jacobs; E J Modestino; N DiNubile; D Baron; T McLaughlin; D Siwicki; I Elman; M Moran; E R Braverman; P K Thanos; R D Badgaiyan
Journal:  SEJ Surg Pain       Date:  2018-10-04

Review 3.  Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

Authors:  Margaret A Madigan; Ashim Gupta; Abdalla Bowirrat; David Baron; Rajendra D Badgaiyan; Igor Elman; Catherine A Dennen; Eric R Braverman; Mark S Gold; Kenneth Blum
Journal:  Int J Environ Res Public Health       Date:  2022-05-24       Impact factor: 4.614

4.  Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD).

Authors:  Kenneth Blum; Margaret A Madigan; Lyle Fried; Eric R Braverman; John Giordano; Rajendra D Badgaiyan
Journal:  Glob J Addict Rehabil Med       Date:  2017-02-23

5.  GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM): LESSONS LEARNED FROM AMERICA.

Authors:  Kenneth Blum; Edward J Modestino; Marjorie C Gondré-Lewis; Jennifer Neary; David Siwicki; Mary Hauser; Debmalya Barh; Bruce Steinberg; Rajendra D Badgaiyan
Journal:  Precis Med (Bangalore)       Date:  2017-11-18

6.  The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population.

Authors:  Kenneth Blum; David Siwicki; David Baron; Edward J Modestino; Rajendra D Badgaiyan
Journal:  J Syst Integr Neurosci       Date:  2018-09-14

Review 7.  Gene-Dairy Food Interactions and Health Outcomes: A Review of Nutrigenetic Studies.

Authors:  Kevin B Comerford; Gonca Pasin
Journal:  Nutrients       Date:  2017-07-06       Impact factor: 5.717

8.  Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis.

Authors:  Kenneth Blum; Jag Khalsa; Jean Lud Cadet; David Baron; Abdalla Bowirrat; Brent Boyett; Lisa Lott; Raymond Brewer; Marjorie Gondré-Lewis; Gregory Bunt; Shan Kazmi; Mark S Gold
Journal:  Front Psychiatry       Date:  2021-03-30       Impact factor: 4.157

Review 9.  Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.

Authors:  Olivia White; Nicole Roeder; Kenneth Blum; Rina D Eiden; Panayotis K Thanos
Journal:  Int J Environ Res Public Health       Date:  2022-08-02       Impact factor: 4.614

Review 10.  Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?

Authors:  Mark S Gold; David Baron; Abdalla Bowirrat; Kenneth Blum
Journal:  J Neurol Sci       Date:  2020-09-15       Impact factor: 3.181

  10 in total

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