Literature DB >> 29911684

Insurance Companies Fighting the Peer Review Empire without any Validity: the Case for Addiction and Pain Modalities in the face of an American Drug Epidemic.

K Blum1,2,3,4,5,6,7,8,9,10, W Jacobs11, E J Modestino12, N DiNubile13, D Baron1, T McLaughlin14, D Siwicki3, I Elman8, M Moran3,15, E R Braverman4, P K Thanos16, R D Badgaiyan17.   

Abstract

The United States are amid an opioid overdose epidemic; we are challenged to provide non-addicting/non-pharmacological alternatives to assist in pain attenuation. There are proven strategies available to manage chronic pain effectively without opioids. Utilization review providers for insurance companies often ignore medicine based scientific peer-reviewed studies that warn against the chronic use of opioid medications, as well as the lack of evidence to support long-term use of opioids for pain. This paradigm must change if we are to indeed change the drug-embracing culture in American chronic pain management. A barrier to treatment is pushback on the part of insurance companies especially as it relates to fighting against pain relief alternatives compared to classical analgesic agents. Pain specialists in the U.S., are compelled to find alternative solutions to help pain victims without promoting unwanted tolerance to analgesics and subsequent biological induction of the "addictive brain." It is noteworthy that reward center of the brain plays a crucial role in the modulation of nociception, and that adaptations in dopaminergic circuitry may affect several sensory and affective components of chronic pain syndromes. Possibly knowing a patient's genetic addiction risk score (GARS™) could eliminate guessing as it relates to becoming addicted.

Entities:  

Keywords:  Addiction; Evidence-based medicine; Genetic addiction risk score GARSTM; Opioid epidemic

Year:  2018        PMID: 29911684      PMCID: PMC5998670     

Source DB:  PubMed          Journal:  SEJ Surg Pain


  58 in total

1.  Does it take too long to publish research?

Authors:  Kendall Powell
Journal:  Nature       Date:  2016-02-11       Impact factor: 49.962

Review 2.  Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land?

Authors:  Kenneth Blum; Peter K Thanos; Rajendra D Badgaiyan; Marcelo Febo; Marlene Oscar-Berman; James Fratantonio; Zsolt Demotrovics; Mark S Gold
Journal:  Expert Opin Biol Ther       Date:  2015-05-14       Impact factor: 4.388

Review 3.  Surgical options for complex craniofacial pain.

Authors:  Mayur Sharma; Andrew Shaw; Milind Deogaonkar
Journal:  Neurosurg Clin N Am       Date:  2014-10       Impact factor: 2.509

4.  A Systematic, Intensive Statistical Investigation of Data from the Comprehensive Analysis of Reported Drugs (CARD) for Compliance and Illicit Opioid Abstinence in Substance Addiction Treatment with Buprenorphine/naloxone.

Authors:  Kenneth Blum; David Han; Edward J Modestino; Scott Saunders; A Kennison Roy; W Jacobs; Darryl S Inaba; David Baron; Marlene Oscar-Berman; Mary Hauser; Rajendra D Badgaiyan; David E Smith; John Femino; Mark S Gold
Journal:  Subst Use Misuse       Date:  2017-12-19       Impact factor: 2.164

5.  Vermont responds to its opioid crisis.

Authors:  Thomas A Simpatico
Journal:  Prev Med       Date:  2015-04-11       Impact factor: 4.018

6.  GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM): LESSONS LEARNED FROM AMERICA.

Authors:  Kenneth Blum; Edward J Modestino; Marjorie C Gondré-Lewis; Jennifer Neary; David Siwicki; Mary Hauser; Debmalya Barh; Bruce Steinberg; Rajendra D Badgaiyan
Journal:  Precis Med (Bangalore)       Date:  2017-11-18

7.  H-Wave induces arteriolar vasodilation in rat striated muscle via nitric oxide-mediated mechanisms.

Authors:  Thomas L Smith; Kenneth Blum; Michael F Callahan; Nicholas A DiNubile; Thomas J H Chen; Roger L Waite
Journal:  J Orthop Res       Date:  2009-09       Impact factor: 3.494

8.  Prescription Drug Monitoring Programs Are Associated With Sustained Reductions In Opioid Prescribing By Physicians.

Authors:  Yuhua Bao; Yijun Pan; Aryn Taylor; Sharmini Radakrishnan; Feijun Luo; Harold Alan Pincus; Bruce R Schackman
Journal:  Health Aff (Millwood)       Date:  2016-06-01       Impact factor: 6.301

Review 9.  Epigenetic mechanisms of drug addiction.

Authors:  Eric J Nestler
Journal:  Neuropharmacology       Date:  2013-04-30       Impact factor: 5.250

Review 10.  Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review.

Authors:  S R Smith; B R Deshpande; J E Collins; J N Katz; E Losina
Journal:  Osteoarthritis Cartilage       Date:  2016-02-01       Impact factor: 6.576

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  4 in total

Review 1.  Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

Authors:  Margaret A Madigan; Ashim Gupta; Abdalla Bowirrat; David Baron; Rajendra D Badgaiyan; Igor Elman; Catherine A Dennen; Eric R Braverman; Mark S Gold; Kenneth Blum
Journal:  Int J Environ Res Public Health       Date:  2022-05-24       Impact factor: 4.614

2.  Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis.

Authors:  Kenneth Blum; Jag Khalsa; Jean Lud Cadet; David Baron; Abdalla Bowirrat; Brent Boyett; Lisa Lott; Raymond Brewer; Marjorie Gondré-Lewis; Gregory Bunt; Shan Kazmi; Mark S Gold
Journal:  Front Psychiatry       Date:  2021-03-30       Impact factor: 4.157

Review 3.  A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing "Precision Behavioral Management".

Authors:  Kenneth Blum; Bruce Steinberg; Marjorie C Gondre-Lewis; David Baron; Edward J Modestino; Rajendra D Badgaiyan; B William Downs; Debasis Bagchi; Raymond Brewer; Thomas McLaughlin; Abdalla Bowirrat; Mark Gold
Journal:  Psychol Res Behav Manag       Date:  2021-12-17

4.  Americas' opioid/psychostimulant epidemic would benefit from general population early identification of genetic addiction risk especially in children of alcoholics (COAs).

Authors:  K Blum; D Baron; M Hauser; S Henriksen; P K Thanos; C Black; D Siwicki; E J Modestino; B W Downs; S Badgaiyan; T A Simpatico; B Boyett; R D Badgaiyan
Journal:  J Syst Integr Neurosci       Date:  2019-10-31
  4 in total

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