So-Young Lee1, Dong Ho Yang1, Eunah Hwang2, Seock Hui Kang3, Sun-Hee Park4, Tae Woo Kim5, Duk Hyun Lee6, Kisoo Park7, Jun Chul Kim8. 1. Department of Internal Medicine, Division of Nephrology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea. 2. Department of Internal Medicine, Division of Nephrology, Keimyung University School of Medicine, Daegu, South Korea. 3. Department of Internal Medicine, Division of Nephrology, Yeungnam University Hospital, Daegu, South Korea. 4. Department of Internal Medicine, Division of Nephrology, Kyungpook National University Hospital, Daegu, South Korea. 5. Department of Internal Medicine, Division of Nephrology, Soonchunhyang University Gumi Hospital, Gumi, South Korea. 6. Department of Internal Medicine, Division of Nephrology, Daegu Fatima Hospital, Daegu, South Korea. 7. Department of Preventive Medicine, School of Medicine Gyeongsang National University, Jinju, South Korea. 8. Department of Internal Medicine, Division of Nephrology, CHA Gumi Medical Center, CHA University, Gumi, South Korea. Electronic address: truedoc1@hanmail.net.
Abstract
OBJECTIVE: To investigate the clinical implications of frailty in chronic kidney disease patients undergoing maintenance hemodialysis and chronic peritoneal dialysis. DESIGN: In this prospective study, all of the participants completed the Short Form of the Kidney Disease Quality of Life questionnaire, Korean version, to determine their frailty phenotype. We also obtained blood chemistry and demographic data at enrollment. Data regarding the history of hospitalization and death were collected during the follow-up period. SUBJECTS: We recruited 1,658 patients (1,255 maintenance hemodialysis and 403 chronic peritoneal dialysis) from multidialysis units (n = 27). We excluded patients who had been hospitalized in the previous 3 months. MAIN OUTCOME MEASURES: Hospitalization and survival rate during study period. RESULTS: The participants' mean age was 55.2 ± 11.9 years old, and 55.2% were male. Among the participants, 34.8% were rated as frail and 45.7% as prefrail. Multivariate analysis demonstrated significant associations of frailty with age, comorbidity, disability, unemployment, higher body mass index, and a lower educational level. During the follow-up period (median 17.1 months), 608 patients (79 not frail, 250 prefrail, and 279 frail) were hospitalized, and 87 patients (10 not frail, 24 prefrail, and 53 frail) died (P < .001). Frailty was associated with hospitalization (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38-2.36) and mortality (hazard ratio, 2.37, 95% confidence interval: 1.11-5.02). CONCLUSION: The frailty phenotype was common even in, prevalent end-stage renal disease patients on dialysis, and was significantly associated with higher rates of hospitalization and mortality.
OBJECTIVE: To investigate the clinical implications of frailty in chronic kidney diseasepatients undergoing maintenance hemodialysis and chronic peritoneal dialysis. DESIGN: In this prospective study, all of the participants completed the Short Form of the Kidney Disease Quality of Life questionnaire, Korean version, to determine their frailty phenotype. We also obtained blood chemistry and demographic data at enrollment. Data regarding the history of hospitalization and death were collected during the follow-up period. SUBJECTS: We recruited 1,658 patients (1,255 maintenance hemodialysis and 403 chronic peritoneal dialysis) from multidialysis units (n = 27). We excluded patients who had been hospitalized in the previous 3 months. MAIN OUTCOME MEASURES: Hospitalization and survival rate during study period. RESULTS: The participants' mean age was 55.2 ± 11.9 years old, and 55.2% were male. Among the participants, 34.8% were rated as frail and 45.7% as prefrail. Multivariate analysis demonstrated significant associations of frailty with age, comorbidity, disability, unemployment, higher body mass index, and a lower educational level. During the follow-up period (median 17.1 months), 608 patients (79 not frail, 250 prefrail, and 279 frail) were hospitalized, and 87 patients (10 not frail, 24 prefrail, and 53 frail) died (P < .001). Frailty was associated with hospitalization (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38-2.36) and mortality (hazard ratio, 2.37, 95% confidence interval: 1.11-5.02). CONCLUSION: The frailty phenotype was common even in, prevalent end-stage renal diseasepatients on dialysis, and was significantly associated with higher rates of hospitalization and mortality.
Authors: Priyadarshini Manay; Patrick Ten Eyck; Roberto Kalil; Melissa Swee; M Lee Sanders; Grace Binns; Jodell L Hornickel; Daniel A Katz Journal: Surgery Date: 2020-08-26 Impact factor: 3.982
Authors: Jinkyung Cho; Inhwan Lee; Soo Hyun Park; Youngyun Jin; Donghyun Kim; Ji Young Kong; Hyunsik Kang Journal: Biomed Res Int Date: 2017-12-14 Impact factor: 3.411