Mary S Wolff1, Jessie P Buckley, Stephanie M Engel, Rob S McConnell, Dana B Barr. 1. aIcahn School of Medicine at Mount Sinai, New York, New York bUniversity of North Carolina, Chapel Hill, North Carolina cBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland dKeck School of Medicine, University of Southern California, Los Angeles, California eRollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Abstract
PURPOSE OF REVIEW: The purpose of this review is to identify emerging developmental toxicants that are understudied in children's health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals. Exposures to less-toxic chemicals may also be significant if they are very commonly used, thereby generating widespread exposure. Sources of exposure include the workplace, personal, home, and office products; food, water, and air. RECENT FINDINGS: We describe eight exposure categories that contain numerous potential developmental toxicants. References are discussed if reported in PubMed during the past decade at least 10 times more frequently than in 1990-2000. Examples included phthalates, phenols, sunscreens, pesticides, halogenated flame retardants, perfluoroalkyl coatings, nanoparticles, e-cigarettes, and dietary polyphenols. Replacements are often close structural homologs of their precursors. We suggest biomonitoring as preferred means of exposure assessment to emerging chemicals. Some existing analytic methods would require minimal modification to measure these exposures, but others require toxicokinetic and analytic investigation. SUMMARY: A deliberate strategy for biomonitoring of emerging replacement chemicals is warranted, especially in view of concerns regarding developmental toxicity. To prevent adverse health effects, it is important to characterize such exposures before they become widely disseminated.
PURPOSE OF REVIEW: The purpose of this review is to identify emerging developmental toxicants that are understudied in children's health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals. Exposures to less-toxic chemicals may also be significant if they are very commonly used, thereby generating widespread exposure. Sources of exposure include the workplace, personal, home, and office products; food, water, and air. RECENT FINDINGS: We describe eight exposure categories that contain numerous potential developmental toxicants. References are discussed if reported in PubMed during the past decade at least 10 times more frequently than in 1990-2000. Examples included phthalates, phenols, sunscreens, pesticides, halogenated flame retardants, perfluoroalkyl coatings, nanoparticles, e-cigarettes, and dietary polyphenols. Replacements are often close structural homologs of their precursors. We suggest biomonitoring as preferred means of exposure assessment to emerging chemicals. Some existing analytic methods would require minimal modification to measure these exposures, but others require toxicokinetic and analytic investigation. SUMMARY: A deliberate strategy for biomonitoring of emerging replacement chemicals is warranted, especially in view of concerns regarding developmental toxicity. To prevent adverse health effects, it is important to characterize such exposures before they become widely disseminated.
Authors: Anna Kjerstine Rosenmai; Marianne Dybdahl; Mikael Pedersen; Barbara Medea Alice van Vugt-Lussenburg; Eva Bay Wedebye; Camilla Taxvig; Anne Marie Vinggaard Journal: Toxicol Sci Date: 2014-02-22 Impact factor: 4.849
Authors: Stephen S Hecht; Steven G Carmella; Delshanee Kotandeniya; Makenzie E Pillsbury; Menglan Chen; Benjamin W S Ransom; Rachel Isaksson Vogel; Elizabeth Thompson; Sharon E Murphy; Dorothy K Hatsukami Journal: Nicotine Tob Res Date: 2014-10-21 Impact factor: 4.244
Authors: M Krause; A Klit; M Blomberg Jensen; T Søeborg; H Frederiksen; M Schlumpf; W Lichtensteiger; N E Skakkebaek; K T Drzewiecki Journal: Int J Androl Date: 2012-06
Authors: Susan Marie Viet; Jill C Falman; Lori S Merrill; Elaine M Faustman; David A Savitz; Nancy Mervish; Dana B Barr; Lisa A Peterson; Robert Wright; David Balshaw; Barbara O'Brien Journal: Int J Hyg Environ Health Date: 2021-05-23 Impact factor: 7.401