Literature DB >> 28050373

Histopathologic Findings in Autopsies with Emphasis on Interesting and Incidental Findings-A Pathologist's Perspective.

Sapna Patel1, B R Rajalakshmi1, G V Manjunath2.   

Abstract

INTRODUCTION: Autopsy aids to the knowledge of pathology by unveiling the rare lesions which are a source of learning from a pathologist's perspective Some of them are only diagnosed at autopsy as they do not cause any functional derangement. This study emphasizes the various incidental lesions which otherwise would have been unnoticed during a person's life. AIM: The aim of this study was to determine the spectrum of histopathological findings including neoplastic lesions related or unrelated to the cause of death. It was also aimed to highlight various incidental and interesting lesions in autopsies.
MATERIALS AND METHODS: A retrospective study of medicolegal autopsies for six years was undertaken in a tertiary care centre to determine the spectrum of histopathological findings including neoplastic lesions related or unrelated to the cause of death and to highlight various incidental and interesting lesions in autopsies. Statistical Analysis: Individual lesions were described in numbers and incidence in percentage.
RESULTS: The study consisted of a series of 269 autopsy cases and histopathological findings were studied only in 202 cases. The commonest cause of death was pulmonary oedema. The most common incidental histopathological finding noted was atherosclerosis in 55 (27.2%) cases followed by fatty liver in 40 (19.8%) cases. Neoplastic lesions accounted for 2.47% of cases.
CONCLUSION: This study has contributed a handful of findings to the pool of rare lesions in pathology. Some of these lesions encountered which served as feast to a pathologist are tumour to tumour metastasis, a case with coexistent triple lesions, Dubin Johnson syndrome, von Meyenburg complex, Multilocular Cystic Renal Cell Carcinoma (MCRCC), Autosomal Dominant Polycystic Kidney Disease (ADPKD), liver carcinod and an undiagnosed vaso-occlusive sickle cell crisis. Autopsy studies help in the detection of unexpected findings significant enough to have changed patient management had they been recognized before death.

Entities:  

Keywords:  Dubin johnson syndrome; Medicolegal autopsies; Multilocular cystic RCC; Vaso-occlusive crisis

Year:  2016        PMID: 28050373      PMCID: PMC5198326          DOI: 10.7860/JCDR/2016/21106.8850

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  11 in total

Review 1.  Signet-ring cell carcinoma of the stomach metastasizing to renal cell carcinoma: a case report and review of the literature.

Authors:  Yasuhiro Sakai; Naoki Kanomata; Hiroe Itami; Kazuyoshi Kajimoto; Toshiko Sakuma; Chiho Ohbayashi
Journal:  Kobe J Med Sci       Date:  2010-05-18

2.  [Multiple bile duct hamartomas of the liver -- a rare differential diagnosis to liver metastasis].

Authors:  M Hettinger; M Klotz; L Bolay; P Weber
Journal:  Ultraschall Med       Date:  2005-04       Impact factor: 6.548

3.  Acute chest syndrome in sickle-cell disease.

Authors:  S C Davies; P J Luce; A A Win; J F Riordan; M Brozovic
Journal:  Lancet       Date:  1984-01-07       Impact factor: 79.321

4.  Bile duct hamartomas. A report of two cases.

Authors:  S C Wei; G T Huang; C H Chen; J C Sheu; Y M Tsang; H C Hsu; D S Chen
Journal:  J Clin Gastroenterol       Date:  1997-12       Impact factor: 3.062

5.  Unexpected neoplasia in autopsies: potential implications for tissue and organ safety.

Authors:  Mary Ann Sens; XuDong Zhou; Timothy Weiland; A Marvin Cooley
Journal:  Arch Pathol Lab Med       Date:  2009-12       Impact factor: 5.534

6.  [Renal cell carcinoma diagnosed at autopsy in Iceland 1971-2005].

Authors:  Armann Jonsson; Sverrir Hardarson; Vigdis Petursdottir; Helga Bjork Palsdottir; Eirikur Jonsson; Gudmundur V Einarsson; Tomas Gudbjartsson
Journal:  Laeknabladid       Date:  2008-12       Impact factor: 0.548

7.  Neoplastic disease in a medicolegal autopsy material. A retrospective study in northern Sweden.

Authors:  C Gezelius; A Eriksson
Journal:  Z Rechtsmed       Date:  1988

8.  Autopsy diagnoses of malignant neoplasms: how often are clinical diagnoses incorrect?

Authors:  E C Burton; D A Troxclair; W P Newman
Journal:  JAMA       Date:  1998-10-14       Impact factor: 56.272

9.  Primary hepatic carcinoid tumours.

Authors:  M Nikfarjam; V Muralidharan; C Christophi
Journal:  HPB (Oxford)       Date:  2004       Impact factor: 3.647

10.  Clinically undiagnosed prostate carcinoma metastatic to renal oncocytoma.

Authors:  Adam J Horn; Bari E Fritz; Chad A Lagrange; William W West; Subodh M Lele
Journal:  Case Rep Urol       Date:  2012-06-13
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  2 in total

1.  Surgery is the preferred treatment for bile duct hamartomas.

Authors:  Xiao-Yu Yang; Hai-Bo Zhang; Bin Wu; Ai-Jun Li; Xiao-Hui Fu
Journal:  Mol Clin Oncol       Date:  2017-07-31

Review 2.  A Comprehensive Review of Pathological Examination in Forensic Medicine: Past, Present, and Future.

Authors:  Dezy Singh; Ramesh Chand Tiwari; Arvind Kumar; Ashish R Bhute; Ravi P Meshram; Manisha Dikshit; Ved Bhushan Sharma; Bhawana Mittal
Journal:  Cureus       Date:  2022-03-01
  2 in total

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