Literature DB >> 28045592

S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives.

Galal Elgemeie1, Nahed Fathy2, Wafaa Zaghary3, Ayman Farag4.   

Abstract

A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-configuration of these cyanoethylene thioglycosides.

Entities:  

Keywords:  Cyanoethylene; cyanoethylene thioglycosides; pyrazoles; sodium 2-cyanoethylene-1-thiolate salts; thioglycosides

Mesh：

Substances：

Year:  2017        PMID： 28045592     DOI： 10.1080/15257770.2016.1257807

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  6 in total

1.  Crystal structure of N-[6-amino-5-(benzo[d]thia-zol-2-yl)-3-cyano-4-methyl-sulfanyl-2-oxo-1,2-di-hydro-pyridin-1-yl]-4-methyl-benzene-sulfonamide di-methyl-formamide monosolvate.

Authors:  Rasha A Azzam; Galal H Elgemeie; Rasha E Elsayed; Peter G Jones
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-11-03

2.  Crystal structure of 2-cyano-3,3-bis-(ethyl-sulfan-yl)-N-o-tolyl-acryl-amide.

Authors:  Rasha A Azzam; Galal H Elgemeie; Rokia Ramadan; Peter G Jones
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-04-28

3.  Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models.

Authors:  Mamdouh A Abu-Zaied; Samah A Loutfy; Ashraf E Hassan; Galal H Elgemeie
Journal:  Drug Des Devel Ther       Date:  2019-07-26       Impact factor: 4.319

4.  Sofosbuvir Thio-analogues: Synthesis and Antiviral Evaluation of the First Novel Pyridine- and Pyrimidine-Based Thioglycoside Phosphoramidates.

Authors:  Mamdouh Attia Abu-Zaied; Sherif F Hammad; Fathi T Halaweish; Galal Hamza Elgemeie
Journal:  ACS Omega       Date:  2020-06-09

5.  Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: In silico study and preclinical evaluation.

Authors:  M H Sanad; A B Farag; Sabry A Bassem; F A Marzook
Journal:  Toxicol Rep       Date:  2022-02-11

6.  Anti-Covid-19 Drug Analogues: Synthesis of Novel Pyrimidine Thioglycosides as Antiviral Agents Against SARS-COV-2 and Avian Influenza H5N1 Viruses.

Authors:  Mamdouh A Abu-Zaied; Galal H Elgemeie; Nashwa M Mahmoud
Journal:  ACS Omega       Date:  2021-06-24
  6 in total

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