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Literature DB >> 28044166

Rotaxane probes for protease detection by ¹²⁹Xe hyperCEST NMR.

Clancy C Slack¹, Joel A Finbloom², Keunhong Jeong¹, Carson J Bruns², David E Wemmer³, Alexander Pines¹, Matthew B Francis¹.

Abstract

We report a CB6 rotaxane for the 129Xe hyperCEST NMR detection of matrix metalloprotease 2 (MMP-2) activity. MMP-2 is overexpressed in cancer tissue, and hence is a cancer marker. A peptide containing an MMP-2 recognition sequence was incorporated into the rotaxane, synthesized via CB6-promoted click chemistry. Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for 129Xe@CB6 interactions, leading to protease-responsive hyperCEST activation.

Entities: Chemical Disease Gene

Year: 2017 PMID： 28044166 DOI： 10.1039/c6cc09302g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

6 in total

1. Directly Functionalized Cucurbit[7]uril as a Biosensor for the Selective Detection of Protein Interactions by ¹²⁹ Xe hyperCEST NMR.

Authors: Ashley E Truxal; Liping Cao; Lyle Isaacs; David E Wemmer; Alexander Pines
Journal: Chemistry Date: 2019-03-29 Impact factor: 5.236

Review 6. Probing Reversible Guest Binding with Hyperpolarized ¹²⁹Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Authors: Jabadurai Jayapaul; Leif Schröder
Journal: Molecules Date: 2020-02-20 Impact factor: 4.411

6 in total

Rotaxane probes for protease detection by ¹²⁹Xe hyperCEST NMR.

1. Directly Functionalized Cucurbit[7]uril as a Biosensor for the Selective Detection of Protein Interactions by ¹²⁹ Xe hyperCEST NMR.

2. Rotaxane Probes for the Detection of Hydrogen Peroxide by ¹²⁹ Xe HyperCEST NMR Spectroscopy.

Review 3. Molecular Sensing with Host Systems for Hyperpolarized ¹²⁹Xe.

4. Detecting protein-protein interactions by Xe-129 NMR.

Review 5. Nanoparticle-Based Contrast Agents for ¹²⁹Xe HyperCEST NMR and MRI Applications.

Review 6. Probing Reversible Guest Binding with Hyperpolarized ¹²⁹Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Rotaxane probes for protease detection by 129Xe hyperCEST NMR.

1. Directly Functionalized Cucurbit[7]uril as a Biosensor for the Selective Detection of Protein Interactions by 129 Xe hyperCEST NMR.

2. Rotaxane Probes for the Detection of Hydrogen Peroxide by 129 Xe HyperCEST NMR Spectroscopy.

Review 3. Molecular Sensing with Host Systems for Hyperpolarized 129Xe.

4. Detecting protein-protein interactions by Xe-129 NMR.

Review 5. Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications.

Review 6. Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Rotaxane probes for protease detection by ¹²⁹Xe hyperCEST NMR.

1. Directly Functionalized Cucurbit[7]uril as a Biosensor for the Selective Detection of Protein Interactions by ¹²⁹ Xe hyperCEST NMR.

2. Rotaxane Probes for the Detection of Hydrogen Peroxide by ¹²⁹ Xe HyperCEST NMR Spectroscopy.

Review 3. Molecular Sensing with Host Systems for Hyperpolarized ¹²⁹Xe.

Review 5. Nanoparticle-Based Contrast Agents for ¹²⁹Xe HyperCEST NMR and MRI Applications.

Review 6. Probing Reversible Guest Binding with Hyperpolarized ¹²⁹Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.