Literature DB >> 2803938

The clinical correlates of serum CA125 in 169 patients with epithelial ovarian carcinoma.

R E Hawkins1, K Roberts, E Wiltshaw, J Mundy, V R McCready.   

Abstract

Serial CA125 measurements in 169 patients with epithelial ovarian carcinoma were obtained. Changes in serum CA125 measurements are shown to reflect changes in clinical status. For patients with macroscopic disease receiving chemotherapy, the sensitivity and specificity for predicting response are shown to be 95% and 86% respectively. For patients with no known disease, the sensitivity and specificity for detecting relapse are shown to be 86% and 91% respectively. The clinical correlates with the level of serum CA125 were examined and the most important is shown to be amount of residual disease.

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Year:  1989        PMID: 2803938      PMCID: PMC2247108          DOI: 10.1038/bjc.1989.329

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  12 in total

1.  Elevation of CA 125 in patients with benign and malignant ascites.

Authors:  J F Bergmann; J M Bidart; M George; M Beaugrand; V G Levy; C Bohuon
Journal:  Cancer       Date:  1987-01-15       Impact factor: 6.860

2.  Evaluation of serum CA125 values in healthy individuals and pregnant women.

Authors:  Y Haga; K Sakamoto; H Egami; R Yoshimura; M Akagi
Journal:  Am J Med Sci       Date:  1986-07       Impact factor: 2.378

3.  Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA 125) associated with human epithelial ovarian carcinomas.

Authors:  T L Klug; R C Bast; J M Niloff; R C Knapp; V R Zurawski
Journal:  Cancer Res       Date:  1984-03       Impact factor: 12.701

4.  Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types.

Authors:  S E Kabawat; R C Bast; W R Welch; R C Knapp; R B Colvin
Journal:  Am J Clin Pathol       Date:  1983-01       Impact factor: 2.493

5.  A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer.

Authors:  R C Bast; T L Klug; E St John; E Jenison; J M Niloff; H Lazarus; R S Berkowitz; T Leavitt; C T Griffiths; L Parker; V R Zurawski; R C Knapp
Journal:  N Engl J Med       Date:  1983-10-13       Impact factor: 91.245

6.  Ovarian cancer antigen CA 125 levels in pelvic inflammatory disease and pregnancy.

Authors:  H Halila; U H Stenman; M Seppälä
Journal:  Cancer       Date:  1986-04-01       Impact factor: 6.860

7.  Clinical significance of serum CA125 values in patients with cancers of the digestive system.

Authors:  Y Haga; K Sakamoto; H Egami; R Yoshimura; K Mori; M Akagi
Journal:  Am J Med Sci       Date:  1986-07       Impact factor: 2.378

8.  Reactivity of a monoclonal antibody with human ovarian carcinoma.

Authors:  R C Bast; M Feeney; H Lazarus; L M Nadler; R B Colvin; R C Knapp
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

9.  Peritoneal trauma releases CA125?

Authors:  C W Redman; S R Jones; D M Luesley; S E Nicholl; K Kelly; E J Buxton; K K Chan; G R Blackledge
Journal:  Br J Cancer       Date:  1988-10       Impact factor: 7.640

10.  Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker.

Authors:  P A Canney; M Moore; P M Wilkinson; R D James
Journal:  Br J Cancer       Date:  1984-12       Impact factor: 7.640

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  9 in total

1.  Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders.

Authors:  Richard G Moore; Michael Craig Miller; Margaret M Steinhoff; Steven J Skates; Karen H Lu; Geralyn Lambert-Messerlian; Robert C Bast
Journal:  Am J Obstet Gynecol       Date:  2011-12-30       Impact factor: 8.661

Review 2.  Ovarian cancer: the duplicity of CA125 measurement.

Authors:  Amer K Karam; Beth Y Karlan
Journal:  Nat Rev Clin Oncol       Date:  2010-04-06       Impact factor: 66.675

3.  Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer.

Authors:  Eleftheria Kalogera; Nathalie Scholler; Cecelia Powless; Amy Weaver; Ronny Drapkin; Jinping Li; Shi-Wen Jiang; Karl Podratz; Nicole Urban; Sean C Dowdy
Journal:  Gynecol Oncol       Date:  2011-10-28       Impact factor: 5.482

4.  Mathematical model identifies blood biomarker-based early cancer detection strategies and limitations.

Authors:  Sharon S Hori; Sanjiv S Gambhir
Journal:  Sci Transl Med       Date:  2011-11-16       Impact factor: 17.956

Review 5.  Current state of biomarker development for clinical application in epithelial ovarian cancer.

Authors:  Richard G Moore; Shannon MacLaughlan; Robert C Bast
Journal:  Gynecol Oncol       Date:  2009-10-31       Impact factor: 5.482

6.  Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction.

Authors:  Manja Idorn; Maria Olsen; Hólmfrídur Rósa Halldórsdóttir; Signe Koggersbøl Skadborg; Magnus Pedersen; Claus Høgdall; Estrid Høgdall; Özcan Met; Per Thor Straten
Journal:  Oncoimmunology       Date:  2017-12-26       Impact factor: 8.110

7.  Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer.

Authors:  S M Scholl; C H Bascou; V Mosseri; R Olivares; H Magdelenat; T Dorval; T Palangié; P Validire; P Pouillart; E R Stanley
Journal:  Br J Cancer       Date:  1994-02       Impact factor: 7.640

8.  Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement.

Authors:  James Bradford Kline; Rina P Kennedy; Earl Albone; Qimin Chao; Shawn Fernando; Jennifer M McDonough; Katherine Rybinski; Wenquan Wang; Elizabeth B Somers; Charles Schweizer; Luigi Grasso; Nicholas C Nicolaides
Journal:  Oncotarget       Date:  2017-07-07

9.  Percutaneous Radiofrequency Ablation Combined With Chemotherapy Versus Chemotherapy Only for Ovarian Cancer Liver Metastasis.

Authors:  Chun-Xue Wu; Miao-Ling Chen; Hao Zhang; Jian-Jun Han
Journal:  Front Oncol       Date:  2022-01-03       Impact factor: 6.244

  9 in total

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