Literature DB >> 3026603

Elevation of CA 125 in patients with benign and malignant ascites.

J F Bergmann, J M Bidart, M George, M Beaugrand, V G Levy, C Bohuon.   

Abstract

The presence of CA 125, an ovarian cancer-associated antigen, was assessed in serum and ascites from patients with ovarian cancer (n = 47), hepatocellular carcinoma (n = 21), and liver cirrhosis (n = 40). Abnormal levels of serum CA 125 were observed in 49% of ovarian cancer patients, and in 89% of these same patients with ascites. In all cases of cirrhosis or hepatocellular carcinoma with ascites, CA 125 levels were above 35 U/ml. The specificity and sensitivity of CA 125 measurement for detecting ascites in chronic liver diseases were 73% and 100%, respectively. Furthermore, the CA 125 level was always higher in ascites than in serum. The authors conclude that CA 125 is a nonspecific marker of ascites. This result must be considered in the interpretation of CA 125 elevation in patients with ovarian cancer. Moreover, CA 125 may be of value in the diagnosis and monitoring of peritoneal diseases.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3026603     DOI： 10.1002/1097-0142(19870115)59:2<213::aid-cncr2820590206>3.0.co;2-i

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  23 in total

1.  Non-ovarian peritoneal papillary serous carcinoma with high CA125 levels.

Authors:  H R Rosen; A C Rosen; J Preiser; M Stierer; M Klein; H Hanak
Journal:  Arch Gynecol Obstet       Date:  1992       Impact factor: 2.344

2.  Marked decrease of serum Ca 125 levels after Denver shunt placement in a patient with cirrhosis and refractory ascites.

Authors:  L Leggio; L Abenavoli; C D'Angelo; A Ferrulli; L Vonghia; A Mirijello; R Barbarino; T De Michele; C Zuppi; D Gui; G L Rapaccini; G Gasbarrini; G Addolorato
Journal:  Dig Dis Sci       Date:  2006-08-22       Impact factor: 3.199

3.  Ascites with a raised CA 125.

Authors:  D J D'Souza; E J Walker
Journal:  J R Soc Med       Date:  1997-08       Impact factor: 5.344

4.  Increased CA 125 in tuberculous peritonitis.

Authors:  J Collazos
Journal:  Gut       Date:  1995-08       Impact factor: 23.059

5.  Intestinal obstruction due to diffuse peritoneal fibrosis at 2 years after the successful treatment of malignant peritoneal mesothelioma with intraperitoneal mitoxantrone.

Authors:  L T Vlasveld; B G Taal; B B Kroon; M P Gallee; S Rodenhuis
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

6.  Elevated CA125 serum levels in a patient with tuberculous peritonitis.

Authors:  A Imai; T Itoh; K Niwa; T Tamaya
Journal:  Arch Gynecol Obstet       Date:  1991       Impact factor: 2.344

7.  Purification and immunochemical characterization of ascitic fluid glycoproteins containing certain tumor-associated and blood group antigen markers.

Authors:  M Venegas; L Liu; L Lovell; L E Davis; B Anderson; T Wilbanks; M Hass; G Manderino; H Rittenhouse
Journal:  Glycoconj J       Date:  1989       Impact factor: 2.916

8.  LETTER TO THE EDITOR: Is the Determination of CA-125 Serum Levels Useful for the Diagnosis of Pulmonary Tuberculosis?

Authors:  Julio Collazos
Journal:  Open Respir Med J       Date:  2010-03-19

9.  CA 125 secretion by peritoneal mesothelial cells.

Authors:  A M Zeillemaker; H A Verbrugh; A A Hoynck van Papendrecht; P Leguit
Journal:  J Clin Pathol       Date:  1994-03       Impact factor: 3.411

10.  Correlative imaging study in the diagnosis of ovarian cancer recurrences. The INSERM Research Network (Nantes, Rennes, Reims, Villejuif, Saclay), France.

Authors:  P Peltier; K Wiharto; J P Dutin; J F Chatal; P Bourguet; J C Liehn; J P Vuillez; J Y Hérry; A Loboguerrero
Journal:  Eur J Nucl Med       Date:  1992
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.