Literature DB >> 28038960

Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance.

Steven R Johnson1, Yonatan Grad2, A Jeanine Abrams3, Kevin Pettus3, David L Trees3.   

Abstract

The whole-genome sequences of 24 isolates of Neisseria gonorrhoeae with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of N. gonorrhoeae FA1090 to determine, by signal ratio, the number of mutant copies of the 23S rRNA gene and the copy number effect on 50S ribosome-mediated azithromycin resistance. Isolates that were predicted to contain four mutated copies were accurately identified compared with the results of direct sequencing. Fewer than four mutated copies gave less accurate results but were consistent with elevated MICs. Published by Elsevier B.V.

Entities:  

Keywords:  23S rRNA; Azithromycin; Neisseria gonorrhoeae; Resistance

Mesh：

Substances：

Year:  2016        PMID： 28038960      PMCID： PMC6927039          DOI： 10.1016/j.ijantimicag.2016.10.023

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  13 in total

1.  Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae.

Authors:  L Zarantonelli; G Borthagaray; E H Lee; W Veal; W M Shafer
Journal:  J Antimicrob Chemother       Date:  2001-05       Impact factor: 5.790

2.  Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.

Authors:  L Zarantonelli; G Borthagaray; E H Lee; W M Shafer
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

3.  A new multidrug-resistant strain of Neisseria gonorrhoeae in Australia.

Authors:  Monica M Lahra; Nathan Ryder; David M Whiley
Journal:  N Engl J Med       Date:  2014-11-06       Impact factor: 91.245

4.  High-level azithromycin resistance occurs in Neisseria gonorrhoeae as a result of a single point mutation in the 23S rRNA genes.

Authors:  Stephanie A Chisholm; Jayshree Dave; Catherine A Ison
Journal:  Antimicrob Agents Chemother       Date:  2010-06-28       Impact factor: 5.191

5.  Treatment failure with 2 g of azithromycin (extended-release formulation) in gonorrhoea in Japan caused by the international multidrug-resistant ST1407 strain of Neisseria gonorrhoeae.

Authors:  Tomoko Morita-Ishihara; Magnus Unemo; Kei-Ichi Furubayashi; Takuya Kawahata; Ken Shimuta; Shu-Ichi Nakayama; Makoto Ohnishi
Journal:  J Antimicrob Chemother       Date:  2014-04-28       Impact factor: 5.790

6.  The Sequence Alignment/Map format and SAMtools.

Authors:  Heng Li; Bob Handsaker; Alec Wysoker; Tim Fennell; Jue Ruan; Nils Homer; Gabor Marth; Goncalo Abecasis; Richard Durbin
Journal:  Bioinformatics       Date:  2009-06-08       Impact factor: 6.937

7.  Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae.

Authors:  Lai-King Ng; Irene Martin; Gary Liu; Louis Bryden
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

8.  Challenges with gonorrhea in the era of multi-drug and extensively drug resistance - are we on the right track?

Authors:  Magnus Unemo; Daniel Golparian; William M Shafer
Journal:  Expert Rev Anti Infect Ther       Date:  2014-04-04       Impact factor: 5.091

Review 9.  Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge.

Authors:  Magnus Unemo
Journal:  BMC Infect Dis       Date:  2015-08-21       Impact factor: 3.090

10.  Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study.

Authors:  Yonatan H Grad; Robert D Kirkcaldy; David Trees; Janina Dordel; Simon R Harris; Edward Goldstein; Hillard Weinstock; Julian Parkhill; William P Hanage; Stephen Bentley; Marc Lipsitch
Journal:  Lancet Infect Dis       Date:  2014-01-22       Impact factor: 25.071
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  10 in total

Review 1.  Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, therapeutic strategies, and molecular resistance prediction.

Authors:  Arlene C Seña; Laura Bachmann; Christine Johnston; Teodora Wi; Kimberly Workowski; Edward W Hook; Jane S Hocking; George Drusano; Magnus Unemo
Journal:  Lancet Infect Dis       Date:  2020-06-19       Impact factor: 25.071

2.  Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance.

Authors:  Cau D Pham; Evelyn Nash; Hsi Liu; Matthew W Schmerer; Samera Sharpe; Grace Woods; Brad Roland; Karen Schlanger; Sancta B St Cyr; Jonathan Carlson; Kevin Sellers; Aaron Olsen; Ruth Sanon; Henrietta Hardin; Olusegun O Soge; Brian H Raphael; Ellen N Kersh
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

Review 3.  Genomic sequencing of Neisseria gonorrhoeae to respond to the urgent threat of antimicrobial-resistant gonorrhea.

Authors:  A Jeanine Abrams; David L Trees
Journal:  Pathog Dis       Date:  2017-06-01       Impact factor: 3.166

4.  Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles.

Authors:  Adam C Retchless; Cécilia B Kretz; How-Yi Chang; Jose A Bazan; A Jeanine Abrams; Abigail Norris Turner; Laurel T Jenkins; David L Trees; Yih-Ling Tzeng; David S Stephens; Jessica R MacNeil; Xin Wang
Journal:  BMC Genomics       Date:  2018-03-02       Impact factor: 3.969

5.  ARIBA: rapid antimicrobial resistance genotyping directly from sequencing reads.

Authors:  Martin Hunt; Alison E Mather; Leonor Sánchez-Busó; Andrew J Page; Julian Parkhill; Jacqueline A Keane; Simon R Harris
Journal:  Microb Genom       Date:  2017-09-04

6.  Azithromycin and Doxycycline Resistance Profiles of U.S. Mycoplasma genitalium Strains and Their Association with Treatment Outcomes.

Authors:  Lisa E Manhart; Patricia A Totten; Gwendolyn E Wood; Nicole L Jensen; Sabina Astete; Jørgen S Jensen; George E Kenny; Christine M Khosropour; Catherine W Gillespie
Journal:  J Clin Microbiol       Date:  2021-08-18       Impact factor: 5.948

Review 7.  Bioinformatics tools used for whole-genome sequencing analysis of Neisseria gonorrhoeae: a literature review.

Authors:  Reema Singh; Anthony Kusalik; Jo-Anne R Dillon
Journal:  Brief Funct Genomics       Date:  2022-04-11       Impact factor: 4.840

8.  Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae.

Authors:  Kevin C Ma; Tatum D Mortimer; Allison L Hicks; Nicole E Wheeler; Leonor Sánchez-Busó; Daniel Golparian; George Taiaroa; Daniel H F Rubin; Yi Wang; Deborah A Williamson; Magnus Unemo; Simon R Harris; Yonatan H Grad
Journal:  Nat Commun       Date:  2020-08-17       Impact factor: 14.919

Review 9.  Evaluation of the accuracy of molecular assays targeting the mutation A2059G for detecting high-level azithromycin resistance in Neisseria gonorrhoeae: a systematic review and meta-analysis.

Authors:  Feng Wang; Jingwei Liu; Hongye Liu; Jing Huang; Shaochun Chen; Xiangsheng Chen; Yueping Yin
Journal:  Infect Drug Resist       Date:  2018-12-28       Impact factor: 4.003

10.  Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.

Authors:  Kevin C Ma; Tatum D Mortimer; Marissa A Duckett; Allison L Hicks; Nicole E Wheeler; Leonor Sánchez-Busó; Yonatan H Grad
Journal:  Nat Commun       Date:  2020-10-23       Impact factor: 14.919
  10 in total

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