Literature DB >> 33139288

Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance.

Cau D Pham1, Evelyn Nash2, Hsi Liu2, Matthew W Schmerer2, Samera Sharpe2, Grace Woods2, Brad Roland2, Karen Schlanger2, Sancta B St Cyr2, Jonathan Carlson3, Kevin Sellers3, Aaron Olsen4, Ruth Sanon5, Henrietta Hardin6, Olusegun O Soge7, Brian H Raphael2, Ellen N Kersh2.   

Abstract

A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotype. Genetic analysis revealed an A2058G mutation of 23S rRNA alleles in all four isolates. In vitro selected gonococcal strains with homozygous A2058G recapitulated the HL-AZMR phenotype. Taken together, we postulate that the A2058G mutation confers HL-AZMR in N. gonorrhoeae.

Entities:  

Keywords:  23s rRNA; A2058G; HL-AZMR; Neisseria gonorrhoeaezzm321990; antibiotic resistance; azithromycin resistant; gonorrhea

Mesh：

Substances：

Year:  2021        PMID： 33139288      PMCID： PMC7848993          DOI： 10.1128/AAC.00885-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

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Review 4.  Expanding U.S. Laboratory Capacity for Neisseria gonorrhoeae Antimicrobial Susceptibility Testing and Whole-Genome Sequencing through the CDC's Antibiotic Resistance Laboratory Network.

Authors:  Ellen N Kersh; Cau D Pham; John R Papp; Robert Myers; Richard Steece; Grace Kubin; Romesh Gautom; Evelyn E Nash; Samera Sharpe; Kim M Gernert; Matthew Schmerer; Brian H Raphael; Tara Henning; Anne M Gaynor; Olusegun Soge; Karen Schlanger; Robert D Kirkcaldy; Sancta B St Cyr; Elizabeth A Torrone; Kyle Bernstein; Hillard Weinstock
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Authors:  Vanessa G Allen; Christine Seah; Irene Martin; Roberto G Melano
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Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

10.  Multidrug-resistant and extensively drug-resistant Neisseria gonorrhoeae in Canada, 2012-2016.

Authors:  I Martin; P Sawatzky; V Allen; B Lefebvre; Lmn Hoang; P Naidu; J Minion; P Van Caeseele; D Haldane; R R Gad; G Zahariadis; A Corriveau; G German; K Tomas; M R Mulvey
Journal:  Can Commun Dis Rep       Date:  2019-02-07
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3.  Whole-genome sequence analysis of high-level penicillin-resistant strains and antimicrobial susceptibility of Neisseria gonorrhoeae clinical isolates from Thailand.

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  5 in total

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