Literature DB >> 11328778

Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae.

L Zarantonelli1, G Borthagaray, E H Lee, W Veal, W M Shafer.   

Abstract

During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded efflux pump system, but remained susceptible to Triton X-100. We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.

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Year:  2001        PMID： 11328778     DOI： 10.1093/jac/47.5.651

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  23 in total

Review 1.  The TetR family of transcriptional repressors.

Authors:  Juan L Ramos; Manuel Martínez-Bueno; Antonio J Molina-Henares; Wilson Terán; Kazuya Watanabe; Xiaodong Zhang; María Trinidad Gallegos; Richard Brennan; Raquel Tobes
Journal:  Microbiol Mol Biol Rev       Date:  2005-06       Impact factor: 11.056

2.  Regulation of mtrF expression in Neisseria gonorrhoeae and its role in high-level antimicrobial resistance.

Authors:  Jason P Folster; William M Shafer
Journal:  J Bacteriol       Date:  2005-06       Impact factor: 3.490

3.  New mutation in 23S rRNA gene associated with high level of azithromycin resistance in Neisseria gonorrhoeae.

Authors:  Patricia G Galarza; Raquel Abad; Liliana Fernández Canigia; Luis Buscemi; Irene Pagano; Claudia Oviedo; Julio A Vázquez
Journal:  Antimicrob Agents Chemother       Date:  2010-02-01       Impact factor: 5.191

Review 4.  Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

5.  Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in Neisseria gonorrhoeae.

Authors:  Crista B Wadsworth; Mohamad R A Sater; Roby P Bhattacharyya; Yonatan H Grad
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

6.  WGS to predict antibiotic MICs for Neisseria gonorrhoeae.

Authors:  David W Eyre; Dilrini De Silva; Kevin Cole; Joanna Peters; Michelle J Cole; Yonatan H Grad; Walter Demczuk; Irene Martin; Michael R Mulvey; Derrick W Crook; A Sarah Walker; Tim E A Peto; John Paul
Journal:  J Antimicrob Chemother       Date:  2017-07-01       Impact factor: 5.790

7.  Relationship between mutation of IR in the mtr system of Neisseria gonorrhoeae and multiple antibiotic resistance.

Authors:  Lixia Zhang; Nengxing Lin; Changzheng Huang; Hongxiang Chen; Yun Lin; Yating Tu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2006

8.  Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness.

Authors:  Douglas M Warner; William M Shafer; Ann E Jerse
Journal:  Mol Microbiol       Date:  2008-08-27       Impact factor: 3.501

Review 9.  Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics.

Authors:  Marilyn C Roberts
Journal:  Mol Biotechnol       Date:  2004-09       Impact factor: 2.695

10.  Acquired macrolide resistance genes in pathogenic Neisseria spp. isolated between 1940 and 1987.

Authors:  Sydney Cousin; William L H Whittington; Marilyn C Roberts
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191
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