Literature DB >> 28034887

Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of Neisseria gonorrhoeae in a Large Health System.

Lao-Tzu Allan-Blitz1, Romney M Humphries2, Peera Hemarajata2, Ashima Bhatti3, Mark W Pandori4, Mark J Siedner5, Jeffrey D Klausner6,7.   

Abstract

Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Neisseria gonorrhoeae; antibiotic resistance.; ciprofloxacin; gyrA

Mesh：

Substances：

Year:  2017        PMID： 28034887      PMCID： PMC5399946          DOI： 10.1093/cid/ciw864

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  10 in total

Review 1.  Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

2.  The antibiotic resistance crisis: part 1: causes and threats.

Authors:  C Lee Ventola
Journal:  P T       Date:  2015-04

3.  Randomized Trial of Rapid Multiplex Polymerase Chain Reaction-Based Blood Culture Identification and Susceptibility Testing.

Authors:  Ritu Banerjee; Christine B Teng; Scott A Cunningham; Sherry M Ihde; James M Steckelberg; James P Moriarty; Nilay D Shah; Jayawant N Mandrekar; Robin Patel
Journal:  Clin Infect Dis       Date:  2015-07-20       Impact factor: 9.079

4.  Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance - The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014.

Authors:  Robert D Kirkcaldy; Alesia Harvey; John R Papp; Carlos Del Rio; Olusegun O Soge; King K Holmes; Edward W Hook; Grace Kubin; Stefan Riedel; Jonathan Zenilman; Kevin Pettus; Tremeka Sanders; Samera Sharpe; Elizabeth Torrone
Journal:  MMWR Surveill Summ       Date:  2016-07-15

Review 5.  Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea.

Authors:  Magnus Unemo; Robert A Nicholas
Journal:  Future Microbiol       Date:  2012-12       Impact factor: 3.165

Review 6.  Stemming the tide of drug-resistant Neisseria gonorrhoeae: the need for an individualized approach to treatment.

Authors:  Sean A Buono; Tyler D Watson; Lee A Borenstein; Jeffrey D Klausner; Mark W Pandori; Hilary A Godwin
Journal:  J Antimicrob Chemother       Date:  2014-10-19       Impact factor: 5.790

7.  Real-time PCR assay for detection of quinolone-resistant Neisseria gonorrhoeae in urine samples.

Authors:  Mark J Siedner; Mark Pandori; Lina Castro; Pennan Barry; William L H Whittington; Sally Liska; Jeffrey D Klausner
Journal:  J Clin Microbiol       Date:  2007-01-31       Impact factor: 5.948

8.  Single-dose ciprofloxacin for the treatment of uncomplicated gonorrhea: a worldwide summary.

Authors:  R M Echols; A Heyd; B J O'Keeffe; P Schacht
Journal:  Sex Transm Dis       Date:  1994 Nov-Dec       Impact factor: 2.830

9.  Performance and Verification of a Real-Time PCR Assay Targeting the gyrA Gene for Prediction of Ciprofloxacin Resistance in Neisseria gonorrhoeae.

Authors:  P Hemarajata; S Yang; O O Soge; R M Humphries; J D Klausner
Journal:  J Clin Microbiol       Date:  2016-01-06       Impact factor: 5.948

Review 10.  Drugs of choice for the treatment of uncomplicated gonococcal infections.

Authors:  J S Moran; W C Levine
Journal:  Clin Infect Dis       Date:  1995-04       Impact factor: 9.079
  10 in total
  26 in total

Review 1.  Wild-Type Gyrase A Genotype of Neisseria gonorrhoeae Predicts In Vitro Susceptibility to Ciprofloxacin: A Systematic Review of the Literature and Meta-Analysis.

Authors:  Lao-Tzu Allan-Blitz; Xiaoyan Wang; Jeffrey D Klausner
Journal:  Sex Transm Dis       Date:  2017-05       Impact factor: 2.830

2.  The Frequency of Discordant Gyrase A Genotypes Among Cases of Multiple Neisseria gonorrhoeae Infections at Different Anatomic Sites.

Authors:  Lao-Tzu Allan-Blitz; Olivia L Ellis; Robert Bolan; Peera Hemarajata; Romney M Humphries; Akbar Shahkolahi; Mark McGrath; Jeffrey D Klausner
Journal:  Sex Transm Dis       Date:  2019-01       Impact factor: 2.830

3.  Point-by-Point Progress: Gonorrhea Point of Care Tests.

Authors:  Charlotte A Gaydos; Johan H Melendez
Journal:  Expert Rev Mol Diagn       Date:  2020-06-30       Impact factor: 5.225

4.  Molecular Characterization of Markers Associated With Antimicrobial Resistance in Neisseria gonorrhoeae Identified From Residual Clinical Samples.

Authors:  Johan H Melendez; Justin Hardick; Mathilda Barnes; Perry Barnes; Christopher D Geddes; Charlotte A Gaydos
Journal:  Sex Transm Dis       Date:  2018-05       Impact factor: 2.830

5.  Ciprofloxacin May be Efficacious in Treating Wild-Type Gyrase A Genotype Neisseria gonorrhoeae Infections.

Authors:  Lao-Tzu Allan-Blitz; Peera Hemarajata; Romney M Humphries; Mabel Kimble; Sam Elias; Jeffrey D Klausner
Journal:  Sex Transm Dis       Date:  2018-04       Impact factor: 2.830

6.  Multiplex Real-Time PCR Assay for Simultaneous Identification of Neisseria gonorrhoeae and Its Ciprofloxacin Susceptibility Status.

Authors:  Sumudu R Perera; Nurul H Khan; Irene Martin; Ali Taheri; Rajinder P Parti; Paul N Levett; Greg B Horsman; Anthony Kusalik; Jo-Anne R Dillon
Journal:  J Clin Microbiol       Date:  2017-08-16       Impact factor: 5.948

7.  A Cost Analysis of Gyrase A Testing and Targeted Ciprofloxacin Therapy Versus Recommended 2-Drug Therapy for Neisseria gonorrhoeae Infection.

Authors:  Lao-Tzu Allan-Blitz; Peera Hemarajata; Romney M Humphries; Adriane Wynn; Eddy R Segura; Jeffrey D Klausner
Journal:  Sex Transm Dis       Date:  2018-02       Impact factor: 2.830

8.  Prevalence of Mycoplasma genitalium and Azithromycin-resistant Infections Among Remnant Clinical Specimens, Los Angeles.

Authors:  Lao-Tzu Allan-Blitz; Elisa Mokany; Shelley Campeau; Rachel Wee; Chelsea Shannon; Jeffrey D Klausner
Journal:  Sex Transm Dis       Date:  2018-09       Impact factor: 2.830

9.  A multisite implementation of a real-time polymerase chain reaction assay to predict ciprofloxacin susceptibility in Neisseria gonorrhoeae.

Authors:  Olivia Ellis; Peera Hemarajata; Akbar Shahkolahi; Godfred Masinde; Kerry Buchs; Romney M Humphries; Jeffrey D Klausner
Journal:  Diagn Microbiol Infect Dis       Date:  2019-01-14       Impact factor: 2.803

10.  Resistance-Guided Treatment of Gonorrhea: A Prospective Clinical Study.

Authors:  Jeffrey D Klausner; Claire C Bristow; Olusegun O Soge; Akbar Shahkolahi; Toni Waymer; Robert K Bolan; Susan S Philip; Lenore E Asbel; Stephanie N Taylor; Leandro A Mena; Deborah A Goldstein; Jonathan A Powell; Michael R Wierzbicki; Sheldon R Morris
Journal:  Clin Infect Dis       Date:  2021-07-15       Impact factor: 9.079
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.