Literature DB >> 2803273

Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor.

J J Hsuan1, N Totty, M D Waterfield.   

Abstract

Three major autophosphorylation sites are located near the C-terminus of the epidermal growth factor receptor, but a fourth site is repeatedly detected. We report here the purification and sequencing of a tryptic peptide containing this site, Tyr-1086. Furthermore, we demonstrate that additional phosphopeptides are observed following both partial digestion and overdigestion. Finally, we show that Tyr-1086 can be phosphorylated in intact cells.

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Year:  1989        PMID： 2803273      PMCID： PMC1133318          DOI： 10.1042/bj2620659

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  33 in total

1.  Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.

Authors:  P J Bertics; G N Gill
Journal:  J Biol Chem       Date:  1985-11-25       Impact factor: 5.157

2.  Synthetic beta-turn peptides as substrates for a tyrosine protein kinase.

Authors:  D A Tinker; E A Krebs; I C Feltham; S K Attah-Poku; V S Ananthanarayanan
Journal:  J Biol Chem       Date:  1988-04-15       Impact factor: 5.157

3.  Different forms of the epidermal growth factor receptor kinase have different autophosphorylation sites.

Authors:  R E Gates; L E King
Journal:  Biochemistry       Date:  1985-09-10       Impact factor: 3.162

4.  Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.

Authors:  A Ullrich; L Coussens; J S Hayflick; T J Dull; A Gray; A W Tam; J Lee; Y Yarden; T A Libermann; J Schlessinger
Journal:  Nature       Date:  1984 May 31-Jun 6       Impact factor: 49.962

5.  Autophosphorylation sites on the epidermal growth factor receptor.

Authors:  J Downward; P Parker; M D Waterfield
Journal:  Nature       Date:  1984 Oct 4-10       Impact factor: 49.962

6.  Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose.

Authors:  L Ellis; E Clauser; D O Morgan; M Edery; R A Roth; W J Rutter
Journal:  Cell       Date:  1986-06-06       Impact factor: 41.582

7.  Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

Authors:  H Ushiro; S Cohen
Journal:  J Biol Chem       Date:  1980-09-25       Impact factor: 5.157

8.  A monoclonal antibody to the human epidermal growth factor receptor.

Authors:  M D Waterfield; E L Mayes; P Stroobant; P L Bennet; S Young; P N Goodfellow; G S Banting; B Ozanne
Journal:  J Cell Biochem       Date:  1982       Impact factor: 4.429

9.  Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.

Authors:  J A Cooper; F S Esch; S S Taylor; T Hunter
Journal:  J Biol Chem       Date:  1984-06-25       Impact factor: 5.157

10.  Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

Authors:  J Downward; M D Waterfield; P J Parker
Journal:  J Biol Chem       Date:  1985-11-25       Impact factor: 5.157
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  24 in total

Review 1.  The ErbB signaling network: receptor heterodimerization in development and cancer.

Authors:  M A Olayioye; R M Neve; H A Lane; N E Hynes
Journal:  EMBO J       Date:  2000-07-03       Impact factor: 11.598

Review 2.  Epidermal growth factor receptor: elements of intracellular communication.

Authors:  S M Hernández-Sotomayor; G Carpenter
Journal:  J Membr Biol       Date:  1992-06       Impact factor: 1.843

3.  Sequential multiplex analyte capturing for phosphoprotein profiling.

Authors:  Oliver Poetz; Tanja Henzler; Michael Hartmann; Cornelia Kazmaier; Markus F Templin; Thomas Herget; Thomas O Joos
Journal:  Mol Cell Proteomics       Date:  2010-08-03       Impact factor: 5.911

4.  A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

Authors:  Q C Vega; C Cochet; O Filhol; C P Chang; S G Rhee; G N Gill
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

5.  Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.

Authors:  W J Wasilenko; D M Payne; D L Fitzgerald; M J Weber
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

Review 6.  Autophosphorylation: a salient feature of protein kinases.

Authors:  J A Smith; S H Francis; J D Corbin
Journal:  Mol Cell Biochem       Date:  1993-11       Impact factor: 3.396

7.  Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor.

Authors:  Katherine S Yang; Ma Xenia G Ilagan; David Piwnica-Worms; Linda J Pike
Journal:  J Biol Chem       Date:  2009-01-26       Impact factor: 5.157

8.  Physicochemical characterization of the cytoplasmic domain of the epidermal growth factor receptor and evidence for conformational changes associated with its activation by ammonium sulphate.

Authors:  M Gregoriou; P F Jones; J F Timms; J J Yang; S E Radford; A R Rees
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857

9.  A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

Authors:  M Mohammadi; A M Honegger; D Rotin; R Fischer; F Bellot; W Li; C A Dionne; M Jaye; M Rubinstein; J Schlessinger
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

10.  Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.

Authors:  Jennifer L Macdonald-Obermann; Linda J Pike
Journal:  J Biol Chem       Date:  2014-08-01       Impact factor: 5.157
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