Literature DB >> 6328312

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.

A Ullrich, L Coussens, J S Hayflick, T J Dull, A Gray, A W Tam, J Lee, Y Yarden, T A Libermann, J Schlessinger.   

Abstract

The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted v-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain.

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Year:  1984        PMID： 6328312     DOI： 10.1038/309418a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  654 in total

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2.  Rapid characterization of green fluorescent protein fusion proteins on the molecular and cellular level by fluorescence correlation microscopy.

Authors:  R Brock; G Vàmosi; G Vereb; T M Jovin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

3.  Inhibitory effects of EGFR antisense oligodeox ynucleotide in human colorectal cancer cell line.

Authors:  Yong He; Jun Zhou; Jin-Sheng Wu; Ke-Feng Dou
Journal:  World J Gastroenterol       Date:  2000-10       Impact factor: 5.742

4.  Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors.

Authors:  Robert Y C Yang; Katherine S Yang; Linda J Pike; Garland R Marshall
Journal:  Chem Biol Drug Des       Date:  2010-05-04       Impact factor: 2.817

5.  Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.

Authors:  A E Lenferink; J F Simpson; L K Shawver; R J Coffey; J T Forbes; C L Arteaga
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

6.  Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor.

Authors:  Katherine S Yang; Ma Xenia G Ilagan; David Piwnica-Worms; Linda J Pike
Journal:  J Biol Chem       Date:  2009-01-26       Impact factor: 5.157

7.  Epidermal growth factor receptor gene expression and binding capacity in renal cell carcinoma, in relation to tumor stage, grade and DNA ploidy.

Authors:  B Ljungberg; M Gåfvels; J E Damber
Journal:  Urol Res       Date:  1994

8.  Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

Authors:  I Lax; W H Burgess; F Bellot; A Ullrich; J Schlessinger; D Givol
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272

9.  Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

Authors:  I Lax; A Johnson; R Howk; J Sap; F Bellot; M Winkler; A Ullrich; B Vennstrom; J Schlessinger; D Givol
Journal:  Mol Cell Biol       Date:  1988-05       Impact factor: 4.272

10.  Amplified gene for the epidermal growth factor receptor in a human glioblastoma cell line encodes an enzymatically inactive protein.

Authors:  A Wells; J M Bishop; D Helmeste
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272
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