| Literature DB >> 1501243 |
S M Hernández-Sotomayor1, G Carpenter.
Abstract
While EGF has an important function in cell growth regulation, the molecular mechanisms by which intracellular signal connect the EGF: receptor complex on the plasma membrane with the initiation of DNA synthesis and mitogenesis is not well understood. The discovery that rasGAP, PI-3 kinase and PLC-gamma 1 are substrates for the EGF receptor tyrosine kinase has provided a beginning in understanding the biochemistry underlying growth factor receptor transduction.Entities:
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Year: 1992 PMID: 1501243 DOI: 10.1007/bf00231881
Source DB: PubMed Journal: J Membr Biol ISSN: 0022-2631 Impact factor: 1.843