Literature DB >> 2803233

Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor.

G Murphy1, P Koklitis, A F Carne.   

Abstract

Recombinant human tissue inhibitor of metalloproteinases (TIMP) forms complexes with high-Mr active recombinant stromelysin that are stable over long periods under physiological conditions. TIMP-stromelysin complexes could be dissociated in the presence of EDTA at pH 3, releasing free TIMP and destroying stromelysin activity. The dissociated TIMP was apparently unmodified, in contrast with other known protein inhibitors of metalloproteinases and many classes of serine-proteinase inhibitor, which are slowly cleaved.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2803233      PMCID： PMC1138932          DOI： 10.1042/bj2611031

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Human skin fibroblast collagenase: interaction with substrate and inhibitor.

Authors:  H G Welgus; J J Jeffrey; A Z Eisen; W T Roswit; G P Stricklin
Journal:  Coll Relat Res       Date:  1985-03

2.  Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins.

Authors:  C R Merril; D Goldman; S A Sedman; M H Ebert
Journal:  Science       Date:  1981-03-27       Impact factor: 47.728

3.  Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components.

Authors:  W A Galloway; G Murphy; J D Sandy; J Gavrilovic; T E Cawston; J J Reynolds
Journal:  Biochem J       Date:  1983-03-01       Impact factor: 3.857

4.  The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor.

Authors:  T E Cawston; G Murphy; E Mercer; W A Galloway; B L Hazleman; J J Reynolds
Journal:  Biochem J       Date:  1983-05-01       Impact factor: 3.857

5.  Maturation of the head of bacteriophage T4. I. DNA packaging events.

Authors:  U K Laemmli; M Favre
Journal:  J Mol Biol       Date:  1973-11-15       Impact factor: 5.469

6.  The electrophoretically 'slow' and 'fast' forms of the alpha 2-macroglobulin molecule.

Authors:  A J Barrett; M A Brown; C A Sayers
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857

7.  Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.

Authors:  A J Docherty; A Lyons; B J Smith; E M Wright; P E Stephens; T J Harris; G Murphy; J J Reynolds
Journal:  Nature       Date:  1985 Nov 7-13       Impact factor: 49.962

8.  An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases.

Authors:  G Murphy; T E Cawston; J J Reynolds
Journal:  Biochem J       Date:  1981-04-01       Impact factor: 3.857

9.  Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution.

Authors:  D C Rees; W N Lipscomb
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

10.  Amino acid sequence of Streptomyces metallo-proteinase inhibitor from Streptomyces nigrescens TK-23.

Authors:  H Murai; S Hara; T Ikenaka; K Oda; S Murao
Journal:  J Biochem       Date:  1985-01       Impact factor: 3.387
View more
  10 in total

1.  Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1).

Authors:  H Nagase; K Suzuki; T E Cawston; K Brew
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Endothelial-cell-stimulating angiogenesis factor (ESAF) activates progelatinase A (72 kDa type IV collagenase), prostromelysin 1 and procollagenase and reactivates their complexes with tissue inhibitors of metalloproteinases: a role for ESAF in non-inflammatory angiogenesis.

Authors:  B McLaughlin; J B Weiss
Journal:  Biochem J       Date:  1996-08-01       Impact factor: 3.857

Review 3.  Computational sequence analysis of the tissue inhibitor of metalloproteinase family.

Authors:  D A Douglas; Y E Shi; Q A Sang
Journal:  J Protein Chem       Date:  1997-05

4.  Fragmentation of human polymorphonuclear-leucocyte collagenase.

Authors:  V Knäuper; A Osthues; Y A DeClerck; K E Langley; J Bläser; H Tschesche
Journal:  Biochem J       Date:  1993-05-01       Impact factor: 3.857

5.  Localization of the 92 kd gelatinase mRNA in squamous cell and adenocarcinomas of the lung using in situ hybridization.

Authors:  R Canete-Soler; L Litzky; I Lubensky; R J Muschel
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

6.  The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.

Authors:  R V Ward; R M Hembry; J J Reynolds; G Murphy
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

Review 7.  Regulation of matrix metalloproteinases: an overview.

Authors:  Sajal Chakraborti; Malay Mandal; Sudip Das; Amritlal Mandal; Tapati Chakraborti
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396

8.  Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy.

Authors:  Angel Fenol; Maya Rajan Peter; Jayachandran Perayil; Rajesh Vyloppillil; Anuradha Bhaskar
Journal:  Int J Chronic Dis       Date:  2014-01-09

9.  Serum metalloproteinases and their inhibitors: markers for malignant potential.

Authors:  T Baker; S Tickle; H Wasan; A Docherty; D Isenberg; J Waxman
Journal:  Br J Cancer       Date:  1994-09       Impact factor: 7.640

10.  Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination.

Authors:  Suzana Angelica Silva Lustosa; Luciano de Souza Viana; Renato José Affonso; Sandra Regina Morini Silva; Marcos Vinicius Araujo Denadai; Silvia Regina Caminada de Toledo; Indhira Dias Oliveira; Delcio Matos
Journal:  ScientificWorldJournal       Date:  2014-03-04
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.