Literature DB >> 28029718

A SMART data analysis method for constructing adaptive treatment strategies for substance use disorders.

Inbal Nahum-Shani1, Ashkan Ertefaie2, Xi Lucy Lu3, Kevin G Lynch4, James R McKay5, David W Oslin6, Daniel Almirall1.   

Abstract

AIMS: To demonstrate how Q-learning, a novel data analysis method, can be used with data from a sequential, multiple assignment, randomized trial (SMART) to construct empirically an adaptive treatment strategy (ATS) that is more tailored than the ATSs already embedded in a SMART.
METHOD: We use Q-learning with data from the Extending Treatment Effectiveness of Naltrexone (ExTENd) SMART (N = 250) to construct empirically an ATS employing naltrexone, behavioral intervention, and telephone disease management to reduce alcohol consumption over 24 weeks in alcohol dependent individuals.
RESULTS: Q-learning helped to identify a subset of individuals who, despite showing early signs of response to naltrexone, require additional treatment to maintain progress.
CONCLUSIONS: Q-learning can inform the development of more cost-effective, adaptive treatment strategies for treating substance use disorders.
© 2016 Society for the Study of Addiction.

Entities:  

Keywords:  Adaptive interventions; Q-learning; Sequential Multiple Assignment Randomized Trial (SMART); adaptive treatment strategies; alcohol dependence; stepped-care

Mesh：

Substances：

Year:  2017        PMID： 28029718      PMCID： PMC5431579          DOI： 10.1111/add.13743

Source DB:  PubMed          Journal:  Addiction        ISSN： 0965-2140            Impact factor:   6.526


  39 in total

1.  An experimental design for the development of adaptive treatment strategies.

Authors:  S A Murphy
Journal:  Stat Med       Date:  2005-05-30       Impact factor: 2.373

2.  Doubly Robust Learning for Estimating Individualized Treatment with Censored Data.

Authors:  Y Q Zhao; D Zeng; E B Laber; R Song; M Yuan; M R Kosorok
Journal:  Biometrika       Date:  2015-03-01       Impact factor: 2.445

3.  PERFORMANCE GUARANTEES FOR INDIVIDUALIZED TREATMENT RULES.

Authors:  Min Qian; Susan A Murphy
Journal:  Ann Stat       Date:  2011-04-01       Impact factor: 4.028

4.  Do patient characteristics and initial progress in treatment moderate the effectiveness of telephone-based continuing care for substance use disorders?

Authors:  James R McKay; Kevin G Lynch; Donald S Shepard; Jon Morgenstern; Robert F Forman; Helen M Pettinati
Journal:  Addiction       Date:  2005-02       Impact factor: 6.526

Review 5.  A "SMART" design for building individualized treatment sequences.

Authors:  H Lei; I Nahum-Shani; K Lynch; D Oslin; S A Murphy
Journal:  Annu Rev Clin Psychol       Date:  2011-12-12       Impact factor: 18.561

6.  An adaptive approach for identifying cocaine dependent patients who benefit from extended continuing care.

Authors:  James R McKay; Deborah H A Van Horn; Kevin G Lynch; Megan Ivey; Mark S Cary; Michelle L Drapkin; Donna M Coviello; Jennifer G Plebani
Journal:  J Consult Clin Psychol       Date:  2013-09-16

Review 7.  Recommendations for the Design and Analysis of Treatment Trials for Alcohol Use Disorders.

Authors:  Katie Witkiewitz; John W Finney; Alex H S Harris; Daniel R Kivlahan; Henry R Kranzler
Journal:  Alcohol Clin Exp Res       Date:  2015-08-06       Impact factor: 3.455

Review 8.  Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.

Authors:  Markus Heilig; Mark Egli
Journal:  Pharmacol Ther       Date:  2006-03-20       Impact factor: 12.310

9.  Comparing dynamic treatment regimes using repeated-measures outcomes: modeling considerations in SMART studies.

Authors:  Xi Lu; Inbal Nahum-Shani; Connie Kasari; Kevin G Lynch; David W Oslin; William E Pelham; Gregory Fabiano; Daniel Almirall
Journal:  Stat Med       Date:  2015-12-06       Impact factor: 2.373

10.  Using pilot data to size a two-arm randomized trial to find a nearly optimal personalized treatment strategy.

Authors:  Eric B Laber; Ying-Qi Zhao; Todd Regh; Marie Davidian; Anastasios Tsiatis; Joseph B Stanford; Donglin Zeng; Rui Song; Michael R Kosorok
Journal:  Stat Med       Date:  2015-10-28       Impact factor: 2.373
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  12 in total

1.  A sequential multiple assignment randomized trial (SMART) protocol for empirically developing an adaptive preventive intervention for college student drinking reduction.

Authors:  Megan E Patrick; Jeffrey A Boatman; Nicole Morrell; Anna C Wagner; Grace R Lyden; Inbal Nahum-Shani; Cheryl A King; Erin E Bonar; Christine M Lee; Mary E Larimer; David M Vock; Daniel Almirall
Journal:  Contemp Clin Trials       Date:  2020-07-25       Impact factor: 2.226

2.  Power analysis in a SMART design: sample size estimation for determining the best embedded dynamic treatment regime.

Authors:  William J Artman; Inbal Nahum-Shani; Tianshuang Wu; James R Mckay; Ashkan Ertefaie
Journal:  Biostatistics       Date:  2020-07-01       Impact factor: 5.899

3.  Identifying optimal level-of-care placement decisions for adolescent substance use treatment.

Authors:  Denis Agniel; Daniel Almirall; Q Burkhart; Sean Grant; Sarah B Hunter; Eric R Pedersen; Rajeev Ramchand; Beth Ann Griffin
Journal:  Drug Alcohol Depend       Date:  2020-04-28       Impact factor: 4.492

4.  Developing adaptive interventions for adolescent substance use treatment settings: protocol of an observational, mixed-methods project.

Authors:  Sean Grant; Denis Agniel; Daniel Almirall; Q Burkhart; Sarah B Hunter; Daniel F McCaffrey; Eric R Pedersen; Rajeev Ramchand; Beth Ann Griffin
Journal:  Addict Sci Clin Pract       Date:  2017-12-19

5.  Bayesian set of best dynamic treatment regimes: Construction and sample size calculation for SMARTs with binary outcomes.

Authors:  William J Artman; Brent A Johnson; Kevin G Lynch; James R McKay; Ashkan Ertefaie
Journal:  Stat Med       Date:  2022-02-06       Impact factor: 2.497

6.  Deeply Tailored Adaptive Interventions to Reduce College Student Drinking: a Real-World Application of Q-Learning for SMART Studies.

Authors:  Grace R Lyden; David M Vock; Aparajita Sur; Nicole Morrell; Christine M Lee; Megan E Patrick
Journal:  Prev Sci       Date:  2022-05-11

7.  Developing Optimized Adaptive Interventions in Education.

Authors:  Daniel Almirall; Connie Kasari; Daniel F McCaffrey; Inbal Nahum-Shani
Journal:  J Res Educ Eff       Date:  2017-11-29

8.  Noninferiority and equivalence tests in sequential, multiple assignment, randomized trials (SMARTs).

Authors:  Palash Ghosh; Inbal Nahum-Shani; Bonnie Spring; Bibhas Chakraborty
Journal:  Psychol Methods       Date:  2019-09-09

9.  The Effectiveness of Web-Based Tailored Smoking Cessation Interventions on the Quitting Process (Project Quit): Secondary Analysis of a Randomized Controlled Trial.

Authors:  Bibhas Chakraborty; Raju Maiti; Victor J Strecher
Journal:  J Med Internet Res       Date:  2018-06-20       Impact factor: 5.428

10.  Innovative trial approaches in immune-mediated inflammatory diseases: current use and future potential.

Authors:  Michael J Grayling; Theophile Bigirumurame; Svetlana Cherlin; Luke Ouma; Haiyan Zheng; James M S Wason
Journal:  BMC Rheumatol       Date:  2021-07-02
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