M Vitale1, M Masulli1, A A Rivellese1, E Bonora2, F Cappellini3, A Nicolucci4, S Squatrito5, D Antenucci6, A Barrea7, C Bianchi8, F Bianchini9, L Fontana10, P Fornengo11, F Giorgino12, A Gnasso13, E Mannucci14, A Mazzotti15, R Nappo1, A P Palena16, P Pata17, G Perriello18, S Potenziani19, R Radin20, L Ricci21, F Romeo22, C Santini23, M Scarponi24, R Serra25, A Timi18, A A Turco1, M Vedovato26, D Zavaroni27, S Grioni28, G Riccardi1, O Vaccaro29. 1. Deparment of Clinical Medicine and Surgery, Medical School "Federico II" University of Naples, Via S. Pansini, n.5, 80131, Naples, Italy. 2. Divisione di Endocrinologia, Diabete e Metabolismo, Dipartimento di Medicina, Università di Verona, Verona, Italy. 3. Dipartimento di Patologia, Sperimentale, Ospedale di Desio, Università di Milano Bicocca, Milano, Italy. 4. CORESEARCH, Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy. 5. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. 6. U.O. Diabetologia e Malattie Metaboliche, Ospedale F. Renzetti, Lanciano, Italy. 7. U.O.C. Diabetologia, Endocrinologia, Malattie Metaboliche, Campobasso, Italy. 8. U.O. Malattie Metaboliche e Diabetologia, Ospedale di Cisanello, Pisa, Italy. 9. Centro Studi ANMCO, Firenze, Italy. 10. U.O.C. Diabetologia, Ospedale Sandro Pertini, Roma, Italy. 11. Dipartimento di Medicina Generale e Specialistica, AOU Città della Salute e della Scienza di Torino, Torino, Italy. 12. Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari "Aldo Moro", Bari, Italy. 13. U.O. di Malattie del Metabolismo, Università "Magna Graecia", Catanzaro, Italy. 14. Divisione di Endocrinologia e Malattie del Metabolismo, Ospedale Careggi, Firenze, Italy. 15. SSD Malattie del Metabolismo, Policlinico S. Orsola Malphighi, Bologna, Italy. 16. Unità Complessa di Endocrinologia, San Giovanni Rotondo, Italy. 17. U.O. Endocrinologia, "Ospedali Riuniti Papardo", Messina, Italy. 18. MISEM, Università di Perugia, Perugia, Italy. 19. Struttura complessa di Diabetologia, Ospedale Fiorini, Terracina, Italy. 20. UO Endocrinologia/Diabetologia, ASST Valle Olona, Varese, Italy. 21. Struttura complessa di Diabetologia, Ospedale San Donato, Arezzo, Italy. 22. SC Malattie Metaboliche e Diabetologia, ASL Torino 5, Torino, Italy. 23. Endocrinologia e Diabetologia di Cesena, ASL della Romagna, Romagna, Italy. 24. Servizio di Diabetologia, Ospedale San Matteo degli infermi, Spoleto, Italy. 25. Unità Operativa Funzionale di Diabetologia, Lecce, Italy. 26. Centro antidiabetico, Azienda Ospedaliera Giustinianeo, Padova, Italy. 27. Unità Operativa di Diabetologia, Ospedale Guglielmo da Saliceto, Piacenza, Italy. 28. Unità di Epidemiologia e Prevenzione Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy. 29. Deparment of Clinical Medicine and Surgery, Medical School "Federico II" University of Naples, Via S. Pansini, n.5, 80131, Naples, Italy. ovaccaro@unina.it.
Abstract
PURPOSE: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. METHODS: We studied 2573 men and women aged 50-75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. RESULTS: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. CONCLUSIONS: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes.
PURPOSE: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. METHODS: We studied 2573 men and women aged 50-75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. RESULTS: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. CONCLUSIONS: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes.
Authors: James I Dower; Johanna M Geleijnse; Lieke Gijsbers; Peter L Zock; Daan Kromhout; Peter C H Hollman Journal: Am J Clin Nutr Date: 2015-02-25 Impact factor: 7.045
Authors: A Tresserra-Rimbau; E B Rimm; A Medina-Remón; M A Martínez-González; R de la Torre; D Corella; J Salas-Salvadó; E Gómez-Gracia; J Lapetra; F Arós; M Fiol; E Ros; L Serra-Majem; X Pintó; G T Saez; J Basora; J V Sorlí; J A Martínez; E Vinyoles; V Ruiz-Gutiérrez; R Estruch; R M Lamuela-Raventós Journal: Nutr Metab Cardiovasc Dis Date: 2014-01-22 Impact factor: 4.222
Authors: V Neveu; J Perez-Jiménez; F Vos; V Crespy; L du Chaffaut; L Mennen; C Knox; R Eisner; J Cruz; D Wishart; A Scalbert Journal: Database (Oxford) Date: 2010-01-08 Impact factor: 3.451
Authors: Joseph A Rothwell; Jara Perez-Jimenez; Vanessa Neveu; Alexander Medina-Remón; Nouha M'hiri; Paula García-Lobato; Claudine Manach; Craig Knox; Roman Eisner; David S Wishart; Augustin Scalbert Journal: Database (Oxford) Date: 2013-10-07 Impact factor: 3.451
Authors: Moza Mohamed Alzaabi; Rania Hamdy; Naglaa S Ashmawy; Alshaimaa M Hamoda; Fatemah Alkhayat; Neda Naser Khademi; Sara Mahmoud Abo Al Joud; Ali A El-Keblawy; Sameh S M Soliman Journal: Phytochem Rev Date: 2021-05-22 Impact factor: 7.741
Authors: Sara Castro-Barquero; Anna Tresserra-Rimbau; Facundo Vitelli-Storelli; Mónica Doménech; Jordi Salas-Salvadó; Vicente Martín-Sánchez; María Rubín-García; Pilar Buil-Cosiales; Dolores Corella; Montserrat Fitó; Dora Romaguera; Jesús Vioque; Ángel María Alonso-Gómez; Julia Wärnberg; José Alfredo Martínez; Luís Serra-Majem; Francisco José Tinahones; José Lapetra; Xavier Pintó; Josep Antonio Tur; Antonio Garcia-Rios; Laura García-Molina; Miguel Delgado-Rodriguez; Pilar Matía-Martín; Lidia Daimiel; Josep Vidal; Clotilde Vázquez; Montserrat Cofán; Andrea Romanos-Nanclares; Nerea Becerra-Tomas; Rocio Barragan; Olga Castañer; Jadwiga Konieczna; Sandra González-Palacios; Carolina Sorto-Sánchez; Jessica Pérez-López; María Angeles Zulet; Inmaculada Bautista-Castaño; Rosa Casas; Ana María Gómez-Perez; José Manuel Santos-Lozano; María Ángeles Rodríguez-Sanchez; Alicia Julibert; Nerea Martín-Calvo; Pablo Hernández-Alonso; José V Sorlí; Albert Sanllorente; Aina María Galmés-Panadés; Eugenio Cases-Pérez; Leire Goicolea-Güemez; Miguel Ruiz-Canela; Nancy Babio; Álvaro Hernáez; Rosa María Lamuela-Raventós; Ramon Estruch Journal: Nutrients Date: 2020-03-04 Impact factor: 5.717