Literature DB >> 28003035

The Ontario Neurodegenerative Disease Research Initiative (ONDRI).

Sali M K Farhan1, Robert Bartha2, Sandra E Black3, Dale Corbett4, Elizabeth Finger5, Morris Freedman6, Barry Greenberg7, David A Grimes8, Robert A Hegele1, Chris Hudson9, Peter W Kleinstiver10, Anthony E Lang11, Mario Masellis3, William E McIlroy12, Paula M McLaughlin10, Manuel Montero-Odasso13, David G Munoz14, Douglas P Munoz15, Stephen Strother16, Richard H Swartz17, Sean Symons18, Maria Carmela Tartaglia19, Lorne Zinman3, Michael J Strong2.   

Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

Entities:  

Keywords:  Alzheimer’s; Amyotrophic Lateral Sclerosis; Dementia; Frontotemporal Dementia; Neurodegeneration; Parkinson Disease; vascular cognitive impairment

Mesh：

Year:  2016        PMID： 28003035     DOI： 10.1017/cjn.2016.415

Source DB:  PubMed          Journal:  Can J Neurol Sci        ISSN： 0317-1671            Impact factor:   2.104


  20 in total

1.  The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols

Authors:  Glenda M. MacQueen; Stefanie Hassel; Stephen R. Arnott; Addington Jean; Christopher R. Bowie; Signe L. Bray; Andrew D. Davis; Jonathan Downar; Jane A. Foster; Benicio N. Frey; Benjamin I. Goldstein; Geoffrey B. Hall; Kate L. Harkness; Jacqueline Harris; Raymond W. Lam; Catherine Lebel; Roumen Milev; Daniel J. Müller; Sagar V. Parikh; Sakina Rizvi; Susan Rotzinger; Gulshan B. Sharma; Claudio N. Soares; Gustavo Turecki; Fidel Vila-Rodriguez; Joanna Yu; Mojdeh Zamyadi; Stephen C. Strother; Sidney H. Kennedy
Journal:  J Psychiatry Neurosci       Date:  2019-07-01       Impact factor: 6.186

2.  Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases.

Authors:  Miracle Ozzoude; Brenda Varriano; Derek Beaton; Joel Ramirez; Melissa F Holmes; Christopher J M Scott; Fuqiang Gao; Kelly M Sunderland; Paula McLaughlin; Jennifer Rabin; Maged Goubran; Donna Kwan; Angela Roberts; Robert Bartha; Sean Symons; Brian Tan; Richard H Swartz; Agessandro Abrahao; Gustavo Saposnik; Mario Masellis; Anthony E Lang; Connie Marras; Lorne Zinman; Christen Shoesmith; Michael Borrie; Corinne E Fischer; Andrew Frank; Morris Freedman; Manuel Montero-Odasso; Sanjeev Kumar; Stephen Pasternak; Stephen C Strother; Bruce G Pollock; Tarek K Rajji; Dallas Seitz; David F Tang-Wai; John Turnbull; Dar Dowlatshahi; Ayman Hassan; Leanne Casaubon; Jennifer Mandzia; Demetrios Sahlas; David P Breen; David Grimes; Mandar Jog; Thomas D L Steeves; Stephen R Arnott; Sandra E Black; Elizabeth Finger; Maria Carmela Tartaglia
Journal:  Geroscience       Date:  2022-03-16       Impact factor: 7.581

3.  Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.

Authors:  Sali M K Farhan; Daniel P Howrigan; Liam E Abbott; Joseph R Klim; Simon D Topp; Andrea E Byrnes; Claire Churchhouse; Hemali Phatnani; Bradley N Smith; Evadnie Rampersaud; Gang Wu; Joanne Wuu; Aleksey Shatunov; Alfredo Iacoangeli; Ahmad Al Khleifat; Daniel A Mordes; Sulagna Ghosh; Kevin Eggan; Rosa Rademakers; Jacob L McCauley; Rebecca Schüle; Stephan Züchner; Michael Benatar; J Paul Taylor; Michael Nalls; Marc Gotkine; Pamela J Shaw; Karen E Morrison; Ammar Al-Chalabi; Bryan Traynor; Christopher E Shaw; David B Goldstein; Matthew B Harms; Mark J Daly; Benjamin M Neale
Journal:  Nat Neurosci       Date:  2019-11-25       Impact factor: 28.771

4.  Brain-CODE: A Secure Neuroinformatics Platform for Management, Federation, Sharing and Analysis of Multi-Dimensional Neuroscience Data.

Authors:  Anthony L Vaccarino; Moyez Dharsee; Stephen Strother; Don Aldridge; Stephen R Arnott; Brendan Behan; Costas Dafnas; Fan Dong; Kenneth Edgecombe; Rachad El-Badrawi; Khaled El-Emam; Tom Gee; Susan G Evans; Mojib Javadi; Francis Jeanson; Shannon Lefaivre; Kristen Lutz; F Chris MacPhee; Jordan Mikkelsen; Tom Mikkelsen; Nicholas Mirotchnick; Tanya Schmah; Christa M Studzinski; Donald T Stuss; Elizabeth Theriault; Kenneth R Evans
Journal:  Front Neuroinform       Date:  2018-05-23       Impact factor: 4.081

5.  Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease.

Authors:  Allison A Dilliott; Sali M K Farhan; Mahdi Ghani; Christine Sato; Eric Liang; Ming Zhang; Adam D McIntyre; Henian Cao; Lemuel Racacho; John F Robinson; Michael J Strong; Mario Masellis; Dennis E Bulman; Ekaterina Rogaeva; Anthony Lang; Carmela Tartaglia; Elizabeth Finger; Lorne Zinman; John Turnbull; Morris Freedman; Rick Swartz; Sandra E Black; Robert A Hegele
Journal:  J Vis Exp       Date:  2018-04-04       Impact factor: 1.355

Review 6.  Phosphorylation of Threonine 175 Tau in the Induction of Tau Pathology in Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder (ALS-FTSD). A Review.

Authors:  Alexander J Moszczynski; Matthew A Hintermayer; Michael J Strong
Journal:  Front Neurosci       Date:  2018-04-20       Impact factor: 4.677

7.  Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease.

Authors:  Bryan M Wong; Richard W Cheng; Efrem D Mandelcorn; Edward Margolin; Sherif El-Defrawy; Peng Yan; Anna T Santiago; Elena Leontieva; Wendy Lou; Wendy Hatch; Christopher Hudson
Journal:  Transl Vis Sci Technol       Date:  2019-09-11       Impact factor: 3.283

8.  Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI).

Authors:  Manuel Montero-Odasso; Frederico Pieruccini-Faria; Robert Bartha; Sandra E Black; Elizabeth Finger; Morris Freedman; Barry Greenberg; David A Grimes; Robert A Hegele; Christopher Hudson; Peter W Kleinstiver; Anthony E Lang; Mario Masellis; Paula M McLaughlin; Douglas P Munoz; Stephen Strother; Richard H Swartz; Sean Symons; Maria Carmela Tartaglia; Lorne Zinman; Michael J Strong; William McIlroy
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

9.  The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegeneration.

Authors:  Sali M K Farhan; Allison A Dilliott; Mahdi Ghani; Christine Sato; Eric Liang; Ming Zhang; Adam D McIntyre; Henian Cao; Lemuel Racacho; John F Robinson; Michael J Strong; Mario Masellis; Peter St George-Hyslop; Dennis E Bulman; Ekaterina Rogaeva; Robert A Hegele
Journal:  NPJ Genom Med       Date:  2016-09-21       Impact factor: 8.617

10.  Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer's Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years.

Authors:  Arunima Kapoor; Robert Bartha; Sandra E Black; Michael Borrie; Morris Freedman; Fuqiang Gao; Nathan Herrmann; Jennifer Mandzia; Miracle Ozzoude; Joel Ramirez; Christopher J M Scott; Sean Symons; Corinne E Fischer; Andrew Frank; Dallas Seitz; Michael Uri Wolf; Nicolaas Paul L G Verhoeff; Gary Naglie; William Reichman; Mario Masellis; Sara B Mitchell; David F Tang-Wai; Maria Carmela Tartaglia; Sanjeev Kumar; Bruce G Pollock; Tarek K Rajji; Elizabeth Finger; Stephen H Pasternak; Richard H Swartz
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472
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