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Literature DB >> 27993850

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.

Michail S Lionakis¹, Nathaniel D Albert², Muthulekha Swamydas³, Chyi-Chia R Lee⁴, Pius Loetscher⁵, Dimitrios P Kontoyiannis⁶.

Abstract

Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida-infected mice. Here, we found that treatment of immunocompetent Candida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases the kidney fungal burden, and protects from renal tissue injury.

Entities: Chemical Disease Gene Species

Keywords: CCR1; Candida; candidiasis; chemokine receptor

Mesh：

Substances：

Year: 2017 PMID： 27993850 PMCID： PMC5328547 DOI： 10.1128/AAC.02365-16

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

Review 1. Invasive Candidiasis.

Authors: Bart Jan Kullberg; Maiken C Arendrup
Journal: N Engl J Med Date: 2015-10-08 Impact factor: 91.245

2. An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

Authors: L Romani; A Mencacci; E Cenci; G Del Sero; F Bistoni; P Puccetti
Journal: J Immunol Date: 1997-03-01 Impact factor: 5.422

3. The ever-evolving landscape of candidaemia in patients with acute leukaemia: non-susceptibility to caspofungin and multidrug resistance are associated with increased mortality.

Authors: Emily Wang; Dimitrios Farmakiotis; Daisy Yang; Deborah A McCue; Hagop M Kantarjian; Dimitrios P Kontoyiannis; Michael S Mathisen
Journal: J Antimicrob Chemother Date: 2015-04-07 Impact factor: 5.790

4. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.

Authors: Alexandre Bignon; Françoise Gaudin; Patrice Hémon; Hugo Tharinger; Katia Mayol; Thierry Walzer; Pius Loetscher; Michel Peuchmaur; Dominique Berrebi; Karl Balabanian
Journal: J Immunol Date: 2013-12-23 Impact factor: 5.422

Review 5. Invasive Candidiasis.

Authors: Todd P McCarty; Peter G Pappas
Journal: Infect Dis Clin North Am Date: 2015-12-29 Impact factor: 5.982

6. The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

Authors: Volha Ninichuk; Alexander G Khandoga; Stephan Segerer; Pius Loetscher; Achim Schlapbach; Laszlo Revesz; Roland Feifel; Andrej Khandoga; Fritz Krombach; Peter J Nelson; Detlef Schlöndorff; Hans-Joachim Anders
Journal: Am J Pathol Date: 2007-04 Impact factor: 4.307

7. Candida-associated renal papillary necrosis.

Authors: J F Tomashefski; C R Abramowsky
Journal: Am J Clin Pathol Date: 1981-02 Impact factor: 2.493

8. Multistate point-prevalence survey of health care-associated infections.

Authors: Shelley S Magill; Jonathan R Edwards; Wendy Bamberg; Zintars G Beldavs; Ghinwa Dumyati; Marion A Kainer; Ruth Lynfield; Meghan Maloney; Laura McAllister-Hollod; Joelle Nadle; Susan M Ray; Deborah L Thompson; Lucy E Wilson; Scott K Fridkin
Journal: N Engl J Med Date: 2014-03-27 Impact factor: 91.245

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.

Review 1. Invasive Candidiasis.

2. An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

3. The ever-evolving landscape of candidaemia in patients with acute leukaemia: non-susceptibility to caspofungin and multidrug resistance are associated with increased mortality.

4. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.

Review 5. Invasive Candidiasis.

6. The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

7. Candida-associated renal papillary necrosis.

8. Multistate point-prevalence survey of health care-associated infections.

Review 9. New insights into innate immune control of systemic candidiasis.

10. Candida and host determinants of susceptibility to invasive candidiasis.

1. The role of neutrophils in host defense against invasive fungal infections.

Review 2. Local antifungal immunity in the kidney in disseminated candidiasis.

3. Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection.

4. Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection.

Review 5. Targeting Chemokine Receptor CCR1 as a Potential Therapeutic Approach for Multiple Myeloma.

Review 6. The Elusive Anti-Candida Vaccine: Lessons From the Past and Opportunities for the Future.