Erin S LeBlanc1, Joanne H Rizzo1, Kathryn L Pedula1, Kristine Yaffe2, Kristine E Ensrud3, Jane Cauley4, Peggy M Cawthon5, Steven Cummings5, Teresa A Hillier1,6. 1. Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon. 2. Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco School of Medicine and San Francisco VA Medical Center, San Francisco, California. 3. Department of Medicine, University of Minnesota, University of Epidemiology & Community Health, Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, Minnesota. 4. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania. 5. Research Institute, California Pacific Medical Center, San Francisco, California. 6. Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
Abstract
OBJECTIVES: The association between weight change and cognition is controversial. We examined the association between 20-year weight change and cognitive function in late life. DESIGN: Cohort study. SETTING: Study of Osteoporotic Fractures (SOF). PARTICIPANTS: One thousand two hundred eighty-nine older, community-dwelling women (mean baseline age 68 (65-81) and 88 (82-102) at cognitive testing). MEASUREMENTS: Study of Osteoporotic Fractures participants had body weight measured repeatedly over 20 years (mean 8 weights). Adjudicated cognitive status was classified as normal (n = 775) or mild cognitive impairment (MCI)/dementia (n = 514) at Year 20. Logistic models were used to evaluate whether absolute weight change, rate of weight loss per year, presence of abrupt, unrecovered weight loss, and weight variability were associated with MCI or dementia. RESULTS: Women with greater rate of weight loss over 20 years had increased chance of developing MCI or dementia. In age/education/clinic-adjusted "base" models, each 0.5 kg/yr decrease resulted in 30% increased odds of MCI/dementia (OR = 1.30 [95% CI: 1.14, 1.49]). After adjustment for age, education, clinic, depression, and walking speed, there was 17% (OR = 1.17 [95% CI: 1.02, 1.35]) increased odds of MCI/dementia for each 0.5 kg/yr decrease in weight. In base models, variability in weight was significant. Each 1% average deviation from each woman's predicted weight curve was associated with 11% increased odds of MCI/dementia (OR = 1.11 [95% CI: 1.04, 1.18]). The estimate was attenuated after full adjustment (OR = 1.06 [95% CI: 0.99, 1.14]). The presence of an abrupt weight decline was not associated with MCI/dementia. CONCLUSIONS: Rate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years, suggesting that nutritional status, social-environmental factors, and/or adipose tissue function and structure may affect cognitive function with aging.
OBJECTIVES: The association between weight change and cognition is controversial. We examined the association between 20-year weight change and cognitive function in late life. DESIGN: Cohort study. SETTING: Study of Osteoporotic Fractures (SOF). PARTICIPANTS: One thousand two hundred eighty-nine older, community-dwelling women (mean baseline age 68 (65-81) and 88 (82-102) at cognitive testing). MEASUREMENTS: Study of Osteoporotic Fracturesparticipants had body weight measured repeatedly over 20 years (mean 8 weights). Adjudicated cognitive status was classified as normal (n = 775) or mild cognitive impairment (MCI)/dementia (n = 514) at Year 20. Logistic models were used to evaluate whether absolute weight change, rate of weight loss per year, presence of abrupt, unrecovered weight loss, and weight variability were associated with MCI or dementia. RESULTS:Women with greater rate of weight loss over 20 years had increased chance of developing MCI or dementia. In age/education/clinic-adjusted "base" models, each 0.5 kg/yr decrease resulted in 30% increased odds of MCI/dementia (OR = 1.30 [95% CI: 1.14, 1.49]). After adjustment for age, education, clinic, depression, and walking speed, there was 17% (OR = 1.17 [95% CI: 1.02, 1.35]) increased odds of MCI/dementia for each 0.5 kg/yr decrease in weight. In base models, variability in weight was significant. Each 1% average deviation from each woman's predicted weight curve was associated with 11% increased odds of MCI/dementia (OR = 1.11 [95% CI: 1.04, 1.18]). The estimate was attenuated after full adjustment (OR = 1.06 [95% CI: 0.99, 1.14]). The presence of an abrupt weight decline was not associated with MCI/dementia. CONCLUSIONS: Rate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years, suggesting that nutritional status, social-environmental factors, and/or adipose tissue function and structure may affect cognitive function with aging.
Authors: D R Gustafson; K Bäckman; M Waern; S Ostling; X Guo; P Zandi; M M Mielke; C Bengtsson; I Skoog Journal: Neurology Date: 2009-11-10 Impact factor: 9.910
Authors: Annette L Fitzpatrick; Lewis H Kuller; Oscar L Lopez; Paula Diehr; Ellen S O'Meara; W T Longstreth; José A Luchsinger Journal: Arch Neurol Date: 2009-03
Authors: Alice M Arnold; Anne B Newman; Mary Cushman; Jingzhong Ding; Stephen Kritchevsky Journal: J Gerontol A Biol Sci Med Sci Date: 2009-04-22 Impact factor: 6.053
Authors: Erin S LeBlanc; Joanne H Rizzo; Kathryn L Pedula; Kristine Yaffe; Kristine E Ensrud; Jane A Cauley; Peggy M Cawthon; Steven R Cummings; Teresa A Hillier Journal: J Am Geriatr Soc Date: 2018-08-27 Impact factor: 5.562
Authors: Hussein N Yassine; Andrea Anderson; Roberta Brinton; Owen Carmichael; Mark A Espeland; Siobhan Hoscheidt; Christina E Hugenschmidt; Jeffrey N Keller; Anne Peters; Xavier Pi-Sunyer Journal: Neurobiol Aging Date: 2020-04-08 Impact factor: 4.673
Authors: Eun Roh; Soon Young Hwang; Jung A Kim; You-Bin Lee; So-Hyeon Hong; Nam Hoon Kim; Ji A Seo; Sin Gon Kim; Nan Hee Kim; Kyung Mook Choi; Sei Hyun Baik; Hye Jin Yoo Journal: Front Endocrinol (Lausanne) Date: 2020-05-12 Impact factor: 5.555
Authors: Roisin F O'Neill; Lorraine Brennan; Federica Prinelli; Giuseppe Sergi; Caterina Trevisan; Lisette C P G M De Groot; Dorothee Volkert; Stefania Maggi; Marianna Noale; Silvia Conti; Fulvio Adorni; Jayne V Woodside; Michelle C McKinley; Bernadette McGuinness; Chris Cardwell; Claire T McEvoy Journal: Nutr Bull Date: 2022-07-20
Authors: Crystal ManYing Lee; Mark Woodward; G David Batty; Alexa S Beiser; Steven Bell; Claudine Berr; Espen Bjertness; John Chalmers; Robert Clarke; Jean-Francois Dartigues; Kendra Davis-Plourde; Stéphanie Debette; Emanuele Di Angelantonio; Catherine Feart; Ruth Frikke-Schmidt; John Gregson; Mary N Haan; Linda B Hassing; Kathleen M Hayden; Marieke P Hoevenaar-Blom; Jaakko Kaprio; Mika Kivimaki; Georgios Lappas; Eric B Larson; Erin S LeBlanc; Anne Lee; Li-Yung Lui; Eric P Moll van Charante; Toshiharu Ninomiya; Liv Tybjaerg Nordestgaard; Tomoyuki Ohara; Toshiaki Ohkuma; Teemu Palviainen; Karine Peres; Ruth Peters; Nawab Qizilbash; Edo Richard; Annika Rosengren; Sudha Seshadri; Martin Shipley; Archana Singh-Manoux; Bjorn Heine Strand; Willem A van Gool; Eero Vuoksimaa; Kristine Yaffe; Rachel R Huxley Journal: Obes Rev Date: 2020-01-03 Impact factor: 9.213