Jie Shen1, Hui Chen1, Tianjing Zhou1, Simei Zhang1, Liyan Huang1, Xiaozhen Lv2, Yuan Ma3, Yan Zheng4, Changzheng Yuan1,5. 1. School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. 2. Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), Peking University Institute of Mental Health (Sixth Hospital), Beijing, China. 3. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. 4. Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, China. 5. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Abstract
CONTEXT: Weight loss among middle-aged and older adults has been associated with a higher risk of subsequent dementia. However, most studies have limited follow-up durations or suboptimal control for the potential influence of physical frailty (PF). OBJECTIVE: Our study aimed to investigate the long-term and temporal relations of weight change to risk of dementia among middle-aged and older adults in the United States. METHODS: A total of 5985 participants aged 65 years and older were included from the Health and Retirement Study. History of long-term weight change was calculated using 9 repeated body mass index measurements during 1992-2008. We then followed participants' dementia status from 2008 to 2018. Multivariable Cox proportional hazard models were used. RESULTS: During the study follow-up period (mean = 7.54 years), a total of 682 (11.40%) dementia cases were documented. After adjustment for basic demographic and lifestyle factors, participants with weight loss (median: -0.23 kg/m2 per year) were at a significantly higher risk of dementia (HR = 1.60; 95% CI, 1.33, 1.92), compared with the stable weight group (median: 0.11 kg/m2 per year). This association was attenuated but remained strong and significant after further adjustment for PF (HR = 1.57; 95% CI, 1.30, 1.89). Significant association was observed for weight loss assessed approximately 14 to 18 years preceding dementia diagnosis (HR = 1.30; 95% CI, 1.07, 1.58), and was consistent closer to diagnosis. CONCLUSION: Both recent and remote weight loss were associated with a higher risk of later-life dementia among middle-aged and older adults independent of PF status.
CONTEXT: Weight loss among middle-aged and older adults has been associated with a higher risk of subsequent dementia. However, most studies have limited follow-up durations or suboptimal control for the potential influence of physical frailty (PF). OBJECTIVE: Our study aimed to investigate the long-term and temporal relations of weight change to risk of dementia among middle-aged and older adults in the United States. METHODS: A total of 5985 participants aged 65 years and older were included from the Health and Retirement Study. History of long-term weight change was calculated using 9 repeated body mass index measurements during 1992-2008. We then followed participants' dementia status from 2008 to 2018. Multivariable Cox proportional hazard models were used. RESULTS: During the study follow-up period (mean = 7.54 years), a total of 682 (11.40%) dementia cases were documented. After adjustment for basic demographic and lifestyle factors, participants with weight loss (median: -0.23 kg/m2 per year) were at a significantly higher risk of dementia (HR = 1.60; 95% CI, 1.33, 1.92), compared with the stable weight group (median: 0.11 kg/m2 per year). This association was attenuated but remained strong and significant after further adjustment for PF (HR = 1.57; 95% CI, 1.30, 1.89). Significant association was observed for weight loss assessed approximately 14 to 18 years preceding dementia diagnosis (HR = 1.30; 95% CI, 1.07, 1.58), and was consistent closer to diagnosis. CONCLUSION: Both recent and remote weight loss were associated with a higher risk of later-life dementia among middle-aged and older adults independent of PF status.
Authors: Matthew Baumgart; Heather M Snyder; Maria C Carrillo; Sam Fazio; Hye Kim; Harry Johns Journal: Alzheimers Dement Date: 2015-06-01 Impact factor: 21.566
Authors: Clifford R Jack; David S Knopman; William J Jagust; Ronald C Petersen; Michael W Weiner; Paul S Aisen; Leslie M Shaw; Prashanthi Vemuri; Heather J Wiste; Stephen D Weigand; Timothy G Lesnick; Vernon S Pankratz; Michael C Donohue; John Q Trojanowski Journal: Lancet Neurol Date: 2013-02 Impact factor: 44.182
Authors: Shelly L Gray; Melissa L Anderson; Rebecca A Hubbard; Andrea LaCroix; Paul K Crane; Wayne McCormick; James D Bowen; Susan M McCurry; Eric B Larson Journal: J Gerontol A Biol Sci Med Sci Date: 2013-02-18 Impact factor: 6.053
Authors: Matthew J Delmonico; Tamara B Harris; Jung-Sun Lee; Marjolein Visser; Michael Nevitt; Stephen B Kritchevsky; Frances A Tylavsky; Anne B Newman Journal: J Am Geriatr Soc Date: 2007-05 Impact factor: 5.562
Authors: Crystal ManYing Lee; Mark Woodward; G David Batty; Alexa S Beiser; Steven Bell; Claudine Berr; Espen Bjertness; John Chalmers; Robert Clarke; Jean-Francois Dartigues; Kendra Davis-Plourde; Stéphanie Debette; Emanuele Di Angelantonio; Catherine Feart; Ruth Frikke-Schmidt; John Gregson; Mary N Haan; Linda B Hassing; Kathleen M Hayden; Marieke P Hoevenaar-Blom; Jaakko Kaprio; Mika Kivimaki; Georgios Lappas; Eric B Larson; Erin S LeBlanc; Anne Lee; Li-Yung Lui; Eric P Moll van Charante; Toshiharu Ninomiya; Liv Tybjaerg Nordestgaard; Tomoyuki Ohara; Toshiaki Ohkuma; Teemu Palviainen; Karine Peres; Ruth Peters; Nawab Qizilbash; Edo Richard; Annika Rosengren; Sudha Seshadri; Martin Shipley; Archana Singh-Manoux; Bjorn Heine Strand; Willem A van Gool; Eero Vuoksimaa; Kristine Yaffe; Rachel R Huxley Journal: Obes Rev Date: 2020-01-03 Impact factor: 9.213
Authors: Gill Livingston; Jonathan Huntley; Andrew Sommerlad; David Ames; Clive Ballard; Sube Banerjee; Carol Brayne; Alistair Burns; Jiska Cohen-Mansfield; Claudia Cooper; Sergi G Costafreda; Amit Dias; Nick Fox; Laura N Gitlin; Robert Howard; Helen C Kales; Mika Kivimäki; Eric B Larson; Adesola Ogunniyi; Vasiliki Orgeta; Karen Ritchie; Kenneth Rockwood; Elizabeth L Sampson; Quincy Samus; Lon S Schneider; Geir Selbæk; Linda Teri; Naaheed Mukadam Journal: Lancet Date: 2020-07-30 Impact factor: 79.321