Yu-Tung Lan1, Deborah Blacker1,2, Changzheng Yuan3, Lori B Chibnik1,4, Albert Hofman1,5, Yuan Ma1,4. 1. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 2. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 3. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 4. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 5. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Abstract
BACKGROUND: The evidence regarding dementia and late-life weight change is inconsistent, and data on body weight fluctuation and dementia are limited. OBJECTIVE: To test the hypothesis that weight loss and substantial weight fluctuation predict cognitive decline independent of body weight and traditional risk factors of dementia. METHODS: This study utilized longitudinal data from the National Alzheimer's Coordinating Center for 10,639 stroke- and dementia-free older adults (60.9%female, mean age 71.6 years, median follow-up 5.5 years). Trends in weight change and weight fluctuation were estimated for each individual by regressing repeated body weight measurements on time. Cognitive decline was examined as diagnostic progression from normal to mild cognitive impairment (MCI) or dementia and from MCI to dementia. RESULTS: Compared to participants with stable weight, those with weight loss had increased odds of diagnostic progression (adjusted OR = 1.35, 95%CI [1.21, 1.51]). Also, large weight fluctuation was associated with increased odds of diagnostic progression (OR comparing the extreme quartiles = 1.20, 95%CI [1.04, 1.39]) after adjusting for traditional risk factors for dementia and body weight change. The magnitude of the association appeared larger among those older than 80 and those with 3 or more cardiometabolic risk factors at baseline (both p for interaction < 0.05). CONCLUSION: Weight loss and substantial weight fluctuation during late-life were associated with increased odds of cognitive decline independent of body weight and traditional risk factors of dementia. Our results suggested the linkage between late-life body weight instability and cognitive decline especially among those with greater age or higher cardiometabolic risk.
BACKGROUND: The evidence regarding dementia and late-life weight change is inconsistent, and data on body weight fluctuation and dementia are limited. OBJECTIVE: To test the hypothesis that weight loss and substantial weight fluctuation predict cognitive decline independent of body weight and traditional risk factors of dementia. METHODS: This study utilized longitudinal data from the National Alzheimer's Coordinating Center for 10,639 stroke- and dementia-free older adults (60.9%female, mean age 71.6 years, median follow-up 5.5 years). Trends in weight change and weight fluctuation were estimated for each individual by regressing repeated body weight measurements on time. Cognitive decline was examined as diagnostic progression from normal to mild cognitive impairment (MCI) or dementia and from MCI to dementia. RESULTS: Compared to participants with stable weight, those with weight loss had increased odds of diagnostic progression (adjusted OR = 1.35, 95%CI [1.21, 1.51]). Also, large weight fluctuation was associated with increased odds of diagnostic progression (OR comparing the extreme quartiles = 1.20, 95%CI [1.04, 1.39]) after adjusting for traditional risk factors for dementia and body weight change. The magnitude of the association appeared larger among those older than 80 and those with 3 or more cardiometabolic risk factors at baseline (both p for interaction < 0.05). CONCLUSION: Weight loss and substantial weight fluctuation during late-life were associated with increased odds of cognitive decline independent of body weight and traditional risk factors of dementia. Our results suggested the linkage between late-life body weight instability and cognitive decline especially among those with greater age or higher cardiometabolic risk.
Entities:
Keywords:
Alzheimer’s disease; body weight; dementia; epidemiology
Authors: S J Wallner; N Luschnigg; W J Schnedl; T Lahousen; K Sudi; K Crailsheim; R Möller; E Tafeit; R Horejsi Journal: Int J Obes Relat Metab Disord Date: 2004-09
Authors: Erin S LeBlanc; Joanne H Rizzo; Kathryn L Pedula; Kristine Yaffe; Kristine E Ensrud; Jane Cauley; Peggy M Cawthon; Steven Cummings; Teresa A Hillier Journal: J Am Geriatr Soc Date: 2016-12-19 Impact factor: 5.562
Authors: Ira Driscoll; Mark A Espeland; Sylvia Wassertheil-Smoller; Sarah A Gaussoin; Jingzhong Ding; Iris A Granek; Judith K Ockene; Lawrence S Phillips; Kristine Yaffe; Susan M Resnick Journal: Obesity (Silver Spring) Date: 2011-03-10 Impact factor: 5.002
Authors: Rosebud O Roberts; Teresa J H Christianson; Walter K Kremers; Michelle M Mielke; Mary M Machulda; Maria Vassilaki; Rabe E Alhurani; Yonas E Geda; David S Knopman; Ronald C Petersen Journal: JAMA Neurol Date: 2016-01 Impact factor: 18.302
Authors: Carl J Lavie; Paul A McAuley; Timothy S Church; Richard V Milani; Steven N Blair Journal: J Am Coll Cardiol Date: 2014-02-12 Impact factor: 24.094
Authors: Jing Qian; Frank J Wolters; Alexa Beiser; Mary Haan; M Arfan Ikram; Jason Karlawish; Jessica B Langbaum; John M Neuhaus; Eric M Reiman; J Scott Roberts; Sudha Seshadri; Pierre N Tariot; Beth McCarty Woods; Rebecca A Betensky; Deborah Blacker Journal: PLoS Med Date: 2017-03-21 Impact factor: 11.069
Authors: Mark A Espeland; Joni K Evans; Owen Carmichael; Jose A Luchsinger; Santica M Marcovina; Rebecca Neiberg; Karen C Johnson; Steven E Kahn; Kathleen M Hayden Journal: Obesity (Silver Spring) Date: 2022-08-03 Impact factor: 9.298