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Literature DB >> 2792080

Evidence that introns arose at proto-splice sites.

Abstract

The unexpected discovery of introns raised many questions about gene evolution. We provide evidence that actin and tubulin introns were gained between the G and R of the conserved coding sequence C/AAGR that is known to flank introns in general and which we call a proto-splice site. We conclude that the tubulin and actin introns are less ancient than the coding sequence and so could not have been involved in the primary evolution of the tubulin and actin genes.

Entities: Chemical

Mesh：

Substances：
Actins
Tubulin

Year: 1989 PMID： 2792080 PMCID： PMC401080 DOI： 10.1002/j.1460-2075.1989.tb03609.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

59 in total

1. Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins.

Authors: W E Theurkauf; H Baum; J Bo; P C Wensink
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

Review 2. On the origin of RNA splicing and introns.

Authors: P A Sharp
Journal: Cell Date: 1985-09 Impact factor: 41.582

3. Speculations on the early course of evolution.

Authors: J E Darnell; W F Doolittle
Journal: Proc Natl Acad Sci U S A Date: 1986-03 Impact factor: 11.205

4. A putative ancestral actin gene present in a thermophilic eukaryote: novel combination of intron positions.

Authors: A G Wildeman
Journal: Nucleic Acids Res Date: 1988-03-25 Impact factor: 16.971

5. Structure of chick chromosomal genes for calbindin and calretinin.

Authors: P W Wilson; J Rogers; M Harding; V Pohl; G Pattyn; D E Lawson
Journal: J Mol Biol Date: 1988-04-20 Impact factor: 5.469

6. 5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU.

Authors: M Aebi; H Hornig; C Weissmann
Journal: Cell Date: 1987-07-17 Impact factor: 41.582

7. Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region.

Authors: P R Dobner; E Kislauskis; B M Wentworth; L Villa-Komaroff
Journal: Nucleic Acids Res Date: 1987-01-12 Impact factor: 16.971

8. Complete nucleotide sequence of a soybean actin gene.

Authors: D M Shah; R C Hightower; R B Meagher
Journal: Proc Natl Acad Sci U S A Date: 1982-02 Impact factor: 11.205

9. Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker.

Authors: M J Orbach; E B Porro; C Yanofsky
Journal: Mol Cell Biol Date: 1986-07 Impact factor: 4.272

10. A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.

Authors: L F Pratt; D W Cleveland
Journal: EMBO J Date: 1988-04 Impact factor: 11.598

95 in total

9. Diverse soybean actin transcripts contain a large intron in the 5' untranslated leader: structural similarity to vertebrate muscle actin genes.

Authors: L Pearson; R B Meagher
Journal: Plant Mol Biol Date: 1990-04 Impact factor: 4.076

10. Mystery of intron gain.

Authors: Alexei Fedorov; Scott Roy; Larisa Fedorova; Walter Gilbert
Journal: Genome Res Date: 2003-09-15 Impact factor: 9.043

Evidence that introns arose at proto-splice sites.

1. Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins.

Review 2. On the origin of RNA splicing and introns.

3. Speculations on the early course of evolution.

4. A putative ancestral actin gene present in a thermophilic eukaryote: novel combination of intron positions.

5. Structure of chick chromosomal genes for calbindin and calretinin.

6. 5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU.

7. Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region.

8. Complete nucleotide sequence of a soybean actin gene.

9. Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker.

10. A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.

1. Late changes in spliceosomal introns define clades in vertebrate evolution.

2. The signal of ancient introns is obscured by intron density and homolog number.

3. A new Drosophila spliceosomal intron position is common in plants.

4. Large-scale comparison of intron positions among animal, plant, and fungal genes.

5. Prevalence of intron gain over intron loss in the evolution of paralogous gene families.

Review 6. Worm genomes hold the smoking guns of intron gain.

7. Statistical analysis and prediction of the exonic structure of human genes.

8. Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes.

9. Diverse soybean actin transcripts contain a large intron in the 5' untranslated leader: structural similarity to vertebrate muscle actin genes.

10. Mystery of intron gain.