Literature DB >> 2792078

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

L Tora1, A Mullick, D Metzger, M Ponglikitmongkol, I Park, P Chambon.   

Abstract

We demonstrate here that the human oestrogen receptor (hER) cDNA clone pOR8 obtained from MCF-7 cells contains an artefactual point mutation which results in the substitution of a valine for a glycine at amino acid position 400 (Gly-400----Val-400). This mutation in the hormone binding domain of the cloned hER destabilizes its structure and decreases its apparent affinity for oestradiol at 25 degrees C, but not at 4 degrees C, when compared with the wild-type hER with a Gly-400.

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Year:  1989        PMID： 2792078      PMCID： PMC401066          DOI： 10.1002/j.1460-2075.1989.tb03604.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  35 in total

1.  Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.

Authors:  S Green; P Walter; V Kumar; A Krust; J M Bornert; P Argos; P Chambon
Journal:  Nature       Date:  1986 Mar 13-19       Impact factor: 49.962

2.  Sequence and expression of human estrogen receptor complementary DNA.

Authors:  G L Greene; P Gilna; M Waterfield; A Baker; Y Hort; J Shine
Journal:  Science       Date:  1986-03-07       Impact factor: 47.728

Review 3.  The anatomy and taxonomy of protein structure.

Authors:  J S Richardson
Journal:  Adv Protein Chem       Date:  1981

4.  A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

Authors:  E Winter; F Yamamoto; C Almoguera; M Perucho
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

5.  Cloning of the human estrogen receptor cDNA.

Authors:  P Walter; S Green; G Greene; A Krust; J M Bornert; J M Jeltsch; A Staub; E Jensen; G Scrace; M Waterfield
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

6.  Transformation of intact yeast cells treated with alkali cations.

Authors:  H Ito; Y Fukuda; K Murata; A Kimura
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

7.  Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018.

Authors:  D A Bronzert; G L Greene; M E Lippman
Journal:  Endocrinology       Date:  1985-10       Impact factor: 4.736

8.  Oligonucleotide-directed mutagenesis by microscale 'shot-gun' gene synthesis.

Authors:  T Grundström; W M Zenke; M Wintzerith; H W Matthes; A Staub; P Chambon
Journal:  Nucleic Acids Res       Date:  1985-05-10       Impact factor: 16.971

9.  Immunochemical studies of estrogen receptors.

Authors:  G L Greene; N B Sobel; W J King; E V Jensen
Journal:  J Steroid Biochem       Date:  1984-01       Impact factor: 4.292

10.  The N-terminal DNA-binding 'zinc finger' of the oestrogen and glucocorticoid receptors determines target gene specificity.

Authors:  S Green; V Kumar; I Theulaz; W Wahli; P Chambon
Journal:  EMBO J       Date:  1988-10       Impact factor: 11.598
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  97 in total

1.  Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.

Authors:  K Smith-McCune; D Kalman; C Robbins; S Shivakumar; L Yuschenkoff; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

2.  Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.

Authors:  G Castoria; M V Barone; M Di Domenico; A Bilancio; D Ametrano; A Migliaccio; F Auricchio
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

3.  Activation of chromosomal vitellogenin genes in Xenopus oocytes by pure estrogen receptor and independent activation of albumin genes.

Authors:  E A McKenzie; N A Cridland; J Knowland
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

4.  Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

Authors:  T A Pham; J F Elliston; Z Nawaz; D P McDonnell; M J Tsai; B W O'Malley
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

5.  Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.

Authors:  D Picard; V Kumar; P Chambon; K R Yamamoto
Journal:  Cell Regul       Date:  1990-02

6.  Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.

Authors:  V Craig Jordan; Ramona Curpan; Philipp Y Maximov
Journal:  J Natl Cancer Inst       Date:  2015-04-02       Impact factor: 13.506

7.  Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters.

Authors:  Jason Matthews; Björn Wihlén; Jane Thomsen; Jan-Ake Gustafsson
Journal:  Mol Cell Biol       Date:  2005-07       Impact factor: 4.272

8.  In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells.

Authors:  Francesca De Amicis; Alessandra Russo; Paola Avena; Marta Santoro; Adele Vivacqua; Daniela Bonofiglio; Loredana Mauro; Saveria Aquila; Donatella Tramontano; Suzanne A W Fuqua; Sebastiano Andò
Journal:  Mol Nutr Food Res       Date:  2013-01-16       Impact factor: 5.914

9.  Progesterone receptor B recruits a repressor complex to a half-PRE site of the estrogen receptor alpha gene promoter.

Authors:  F De Amicis; S Zupo; M L Panno; R Malivindi; F Giordano; I Barone; L Mauro; S A W Fuqua; S Andò
Journal:  Mol Endocrinol       Date:  2009-01-15

10.  Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

Authors:  G Bunone; P A Briand; R J Miksicek; D Picard
Journal:  EMBO J       Date:  1996-05-01       Impact factor: 11.598
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