Literature DB >> 279022

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.

M V Haspel, P W Lampert, M B Oldstone.   

Abstract

Mutagenesis of mouse hepatitis virus with 5-azacytidine or 5-fluorouracil yielded several temperature-sensitive mutants. Mutants have been isolated that dramatically enhance the production of demyelinating disease over that previously noted with the wild-type virus. This reproducible model should now make possible the precise elucidation of the pathogenic mechanism and molecular basis of this virus-induced demyelination.

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Year:  1978        PMID： 279022      PMCID： PMC392925          DOI： 10.1073/pnas.75.8.4033

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  Tissue culture cytopathic and plaque assays for mouse hepatitis viruses.

Authors:  J W HARTLEY; W P ROWE
Journal:  Proc Soc Exp Biol Med       Date:  1963-06

2.  Neurovirulence and induction of hydrocephalus with parental, mutant, and revertant strains of measles virus.

Authors:  A M Breschkin; M V Haspel; F Rapp
Journal:  J Virol       Date:  1976-05       Impact factor: 5.103

Review 3.  Genetic manipulation of reovirus--a model for modification of disease.

Authors:  B N Fields
Journal:  N Engl J Med       Date:  1972-11-16       Impact factor: 91.245

Review 4.  Viral infections and demyelinating diseases.

Authors:  L P Weiner; R T Johnson; R M Herndon
Journal:  N Engl J Med       Date:  1973-05-24       Impact factor: 91.245

5.  Pathogenesis of demyelination induced by a mouse hepatitis.

Authors:  L P Weiner
Journal:  Arch Neurol       Date:  1973-05

6.  Comparison of central nervous system disease produced by wild-type and temperature-sensitive mutants of vesicular stomatitis virus.

Authors:  S G Rabinowitz; M C Dal Canto; T C Johnson
Journal:  Infect Immun       Date:  1976-04       Impact factor: 3.441

7.  Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies.

Authors:  P W Lampert; J K Sims; A J Kniazeff
Journal:  Acta Neuropathol       Date:  1973-03-30       Impact factor: 17.088

8.  Measles virus: an unwanted variant causing hydrocephalus.

Authors:  M V Haspel; F Rapp
Journal:  Science       Date:  1975-02-07       Impact factor: 47.728

9.  Regeneration of oligodendroglia during recovery from demyelinating disease.

Authors:  R M Herndon; D L Price; L P Weiner
Journal:  Science       Date:  1977-02-18       Impact factor: 47.728

10.  Infectious leukoencephalitis. A critical comparison of certain experimental and naturally-occurring viral leukoencephalitides with experimental allergic encephalomyelitis.

Authors:  B H WAKSMAN; R D ADAMS
Journal:  J Neuropathol Exp Neurol       Date:  1962-10       Impact factor: 3.685
  10 in total
  71 in total

Review 1.  Viral quasispecies evolution.

Authors:  Esteban Domingo; Julie Sheldon; Celia Perales
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

2.  Neutralization-resistant variants of a neurotropic coronavirus are generated by deletions within the amino-terminal half of the spike glycoprotein.

Authors:  T M Gallagher; S E Parker; M J Buchmeier
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

Review 3.  Murine coronavirus infection: a paradigm for virus-induced demyelinating disease.

Authors:  T E Lane; M J Buchmeier
Journal:  Trends Microbiol       Date:  1997-01       Impact factor: 17.079

4.  Sequence analysis reveals extensive polymorphism and evidence of deletions within the E2 glycoprotein gene of several strains of murine hepatitis virus.

Authors:  S E Parker; T M Gallagher; M J Buchmeier
Journal:  Virology       Date:  1989-12       Impact factor: 3.616

5.  Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein.

Authors:  Evelena Ontiveros; Taeg S Kim; Thomas M Gallagher; Stanley Perlman
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

6.  Does the major histocompatibility complex serve as a specific receptor for Semliki Forest virus?

Authors:  M B Oldstone; A Tishon; F J Dutko; S I Kennedy; J J Holland; P W Lampert
Journal:  J Virol       Date:  1980-04       Impact factor: 5.103

7.  Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism.

Authors:  Jayasri Das Sarma; Kathryn Iacono; Lilli Gard; Ryan Marek; Lawrence C Kenyon; Michael Koval; Susan R Weiss
Journal:  J Virol       Date:  2008-04-02       Impact factor: 5.103

8.  Differential susceptibility of cultured neural cells to the human coronavirus OC43.

Authors:  J Pearson; C A Mims
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

9.  Coronavirus JHM-induced demyelinating encephalomyelitis in rats: influence of immunity on the course of disease.

Authors:  H Wege; R Watanabe; M Koga; V Ter Meulen
Journal:  Prog Brain Res       Date:  1983       Impact factor: 2.453

10.  A mechanism of virus-induced demyelination.

Authors:  Jayasri Das Sarma
Journal:  Interdiscip Perspect Infect Dis       Date:  2010-06-21
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