Literature DB >> 2788997

Comparing observed average numbers of affected sibs with those expected under geometric ascertainment bias in an extended range in both simplex and multiple sibships.

K H Sit1.   

Abstract

Detection bias in recessive ascertainment is generally considered to be confined in a narrow range between unbiased truncate ascertainment and single ascertainment, where methods of segregation analysis are established. While there are arguments for an extended range of analysis, a deflated detection progression below the unbiased level is still being considered as theoretical ground or ignored as sporadics. I show here a method of gauging the ascertainment levels of surveyed data in a geometric continuum. The method is valid for recessive segregation at any ascertainment level and in simplex or multiplex sibships of whatever degree of truncation. Four previously published surveys are used to show conformation with real data and the existence of detection trends spanning the range from the unsuspected very depressed bias level to the inflated level above single ascertainment.

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Year:  1989        PMID: 2788997      PMCID: PMC1683409     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN: 0002-9297            Impact factor:   11.025


  12 in total

1.  DWARFISM IN THE AMISH I. THE ELLIS-VAN CREVELD SYNDROME.

Authors:  V A MCKUSICK; J A EGELAND; R ELDRIDGE; D E KRUSEN
Journal:  Bull Johns Hopkins Hosp       Date:  1964-10

2.  RECESSIVE GENES IN SEVERE MENTAL DEFECT.

Authors:  W J DEWEY; I BARRAI; N E MORTON; M P MI
Journal:  Am J Hum Genet       Date:  1965-05       Impact factor: 11.025

3.  A note on the effects of method of ascertainment on segregation ratios.

Authors:  C A SMITH
Journal:  Ann Hum Genet       Date:  1959-07       Impact factor: 1.670

4.  Heredity and rheumatic fever; a study of 462 families ascertained by an affected child and 51 families ascertained by an affected mother.

Authors:  A C STEVENSON; E A CHEESEMAN
Journal:  Ann Eugen       Date:  1953-02

5.  A genetic and statistical study of psoriasis.

Authors:  A G STEINBERG; S W BECKER; T B FITZPATRICK; R R KIERLAND
Journal:  Am J Hum Genet       Date:  1951-09       Impact factor: 11.025

6.  A method of subdividing genetic data into self-contained subsets.

Authors:  C C Li
Journal:  Ann Hum Genet       Date:  1986-07       Impact factor: 1.670

7.  The limits of ascertainment.

Authors:  W J Ewens; N C Shute
Journal:  Ann Hum Genet       Date:  1986-10       Impact factor: 1.670

8.  A simple method of estimating the segregation ratio under complete ascertainment.

Authors:  C C Li; N Mantel
Journal:  Am J Hum Genet       Date:  1968-01       Impact factor: 11.025

9.  The mode of inheritance of psoriasis: evidence for a major gene as well as a multifactorial component and its implication for genetic counselling.

Authors:  L Iselius; W R Williams
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris.

Authors:  T Henseler; E Christophers
Journal:  J Am Acad Dermatol       Date:  1985-09       Impact factor: 11.527

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  1 in total

1.  Simulation of recessive transmission in the combined data of polyposis coli and cancer of the colon.

Authors:  K H Sit
Journal:  Am J Hum Genet       Date:  1990-01       Impact factor: 11.025

  1 in total

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