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Literature DB >> 6500559

The mode of inheritance of psoriasis: evidence for a major gene as well as a multifactorial component and its implication for genetic counselling.

Abstract

Complex segregation analysis of Lomholt's family data on psoriasis on the Faroe Islands gave evidence for an additive major gene with gene frequency of 0.07 and penetrance 0.12 and 0.44 in the heterozygote and in the homozygote, respectively. In addition, there was a multifactorial component with heritability 0.87. The implications of these findings for genetic counseling are discussed and analytical risk figures are presented for chosen pedigrees.

Entities: Disease

Mesh：

Year: 1984 PMID： 6500559 DOI： 10.1007/bf00293877

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. Inheritance of psoriasis in a Utah kindred.

Authors: J H WARD; F E STEPHENS
Journal: Arch Dermatol Date: 1961-10

2. HEREDITY AND PSORIASIS. STUDY OF A LARGE FAMILY.

Authors: D C ABELE; R L DOBSON; J B GRAHAM
Journal: Arch Dermatol Date: 1963-07

3. A genetic and statistical study of psoriasis.

Authors: A G STEINBERG; S W BECKER; T B FITZPATRICK; R R KIERLAND
Journal: Am J Hum Genet Date: 1951-09 Impact factor: 11.025

Review 4. The inheritance of psoriasis.

Authors: W Kimberling; R L Dobson
Journal: J Invest Dermatol Date: 1973-06 Impact factor: 8.551

Review 8. Advances in genetics in dermatology.

Authors: H P Baden; P A Hooker
Journal: Adv Hum Genet Date: 1982

2. Comparing observed average numbers of affected sibs with those expected under geometric ascertainment bias in an extended range in both simplex and multiple sibships.

Authors: K H Sit
Journal: Am J Hum Genet Date: 1989-09 Impact factor: 11.025

2 in total

The mode of inheritance of psoriasis: evidence for a major gene as well as a multifactorial component and its implication for genetic counselling.

1. Inheritance of psoriasis in a Utah kindred.

2. HEREDITY AND PSORIASIS. STUDY OF A LARGE FAMILY.

3. A genetic and statistical study of psoriasis.

Review 4. The inheritance of psoriasis.

5. On the genetics of psoriasis. An analysis of Hellgren's data for a model of multifactorial inheritance.

6. The genetics of psoriasis.

Review 7. Environment and genetics in psoriasis.

Review 8. Advances in genetics in dermatology.

9. Complex segregation analysis with pointers.

10. Probability calculations in pedigrees under complex modes of inheritance.

1. [Genetics of common chronic inflammatory skin diseases : An update on atopic dermatitis and psoriasis].

2. Comparing observed average numbers of affected sibs with those expected under geometric ascertainment bias in an extended range in both simplex and multiple sibships.