Megan Quarmley1, Paul J Moberg1,2,3, Dawn Mechanic-Hamilton2,3, Sushila Kabadi1, Steven E Arnold4, David A Wolk2,3, David R Roalf1. 1. Department of Psychiatry, Philadelphia, PA, USA. 2. Department of Neurology, Philadelphia, PA, USA. 3. Alzheimer's Disease Center of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 4. Department of Neurology of Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Abstract
BACKGROUND: Measurements of olfaction may serve as useful biomarkers of incipient dementia. Here we examine the improvement in diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification. OBJECTIVE: To determine the utility of odor identification as a supplementary screening test in incipient AD. METHODS: Sniffin' Sticks Odor Identification Test (SS-OIT) and the Montreal Cognitive Assessment (MoCA) were administered in 262 AD, 174 MCI [150 amnestic (aMCI), and 24 non-amnestic (naMCI)], and 292 healthy older adults (HOA). RESULTS: Odor identification scores were higher in HOA relative to MCI or AD groups, and MCI outperformed AD. Odor identification scores were higher in aMCI single domain than aMCI multiple domain. Complementing MoCA scores with the SS-OIT significantly improved diagnostic accuracy of individuals with AD and MCI, including within MCI subgroups. DISCUSSION: Odor identification is a useful supplementary screening tool that provides additional information relevant for clinical categorization of AD and MCI, including those who are at highest risk to convert to AD.
BACKGROUND: Measurements of olfaction may serve as useful biomarkers of incipient dementia. Here we examine the improvement in diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification. OBJECTIVE: To determine the utility of odor identification as a supplementary screening test in incipient AD. METHODS: Sniffin' Sticks Odor Identification Test (SS-OIT) and the Montreal Cognitive Assessment (MoCA) were administered in 262 AD, 174 MCI [150 amnestic (aMCI), and 24 non-amnestic (naMCI)], and 292 healthy older adults (HOA). RESULTS: Odor identification scores were higher in HOA relative to MCI or AD groups, and MCI outperformed AD. Odor identification scores were higher in aMCI single domain than aMCI multiple domain. Complementing MoCA scores with the SS-OIT significantly improved diagnostic accuracy of individuals with AD and MCI, including within MCI subgroups. DISCUSSION: Odor identification is a useful supplementary screening tool that provides additional information relevant for clinical categorization of AD and MCI, including those who are at highest risk to convert to AD.
Authors: Matthias H Tabert; Xinhua Liu; Richard L Doty; Michael Serby; Diana Zamora; Gregory H Pelton; Karen Marder; Mark W Albers; Yaakov Stern; D P Devanand Journal: Ann Neurol Date: 2005-07 Impact factor: 10.422
Authors: Davangere P Devanand; Seonjoo Lee; Jennifer Manly; Howard Andrews; Nicole Schupf; Arjun Masurkar; Yaakov Stern; Richard Mayeux; Richard L Doty Journal: Ann Neurol Date: 2015-07-03 Impact factor: 10.422
Authors: D P Devanand; G Pradhaban; X Liu; A Khandji; S De Santi; S Segal; H Rusinek; G H Pelton; L S Honig; R Mayeux; Y Stern; M H Tabert; M J de Leon Journal: Neurology Date: 2007-03-13 Impact factor: 9.910
Authors: D P Devanand; K S Michaels-Marston; X Liu; G H Pelton; M Padilla; K Marder; K Bell; Y Stern; R Mayeux Journal: Am J Psychiatry Date: 2000-09 Impact factor: 18.112
Authors: G Kobal; L Klimek; M Wolfensberger; H Gudziol; A Temmel; C M Owen; H Seeber; E Pauli; T Hummel Journal: Eur Arch Otorhinolaryngol Date: 2000 Impact factor: 2.503
Authors: Sandra Weintraub; David Salmon; Nathaniel Mercaldo; Steven Ferris; Neill R Graff-Radford; Helena Chui; Jeffrey Cummings; Charles DeCarli; Norman L Foster; Douglas Galasko; Elaine Peskind; Woodrow Dietrich; Duane L Beekly; Walter A Kukull; John C Morris Journal: Alzheimer Dis Assoc Disord Date: 2009 Apr-Jun Impact factor: 2.703
Authors: David R Roalf; Madelyn J Moberg; Bruce I Turetsky; Laura Brennan; Sushila Kabadi; David A Wolk; Paul J Moberg Journal: J Neurol Neurosurg Psychiatry Date: 2016-12-30 Impact factor: 10.154
Authors: Davangere P Devanand; Seonjoo Lee; Jose A Luchsinger; Howard Andrews; Terry Goldberg; Edward D Huey; Nicole Schupf; Jennifer Manly; Yaakov Stern; William C Kreisl; Richard Mayeux Journal: Alzheimers Dement Date: 2020-01-04 Impact factor: 21.566
Authors: Kayci L Vickers; Kathleen Breslin; David R Roalf; Vidyulata Kamath; Sharon X Xie; Paul J Moberg; David A Wolk; Dawn Mechanic-Hamilton Journal: Arch Clin Neuropsychol Date: 2019-03-01 Impact factor: 2.813
Authors: Shannon L Risacher; Eileen F Tallman; John D West; Karmen K Yoder; Gary D Hutchins; James W Fletcher; Sujuan Gao; David A Kareken; Martin R Farlow; Liana G Apostolova; Andrew J Saykin Journal: Alzheimers Dement (Amst) Date: 2017-09-23