Davangere P Devanand1,2, Seonjoo Lee3, Jose A Luchsinger4, Howard Andrews5, Terry Goldberg1,2, Edward D Huey2,6,7, Nicole Schupf7,8,9, Jennifer Manly7,8,10, Yaakov Stern6, William C Kreisl7, Richard Mayeux7,10. 1. Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, NY, USA. 2. Department of Psychiatry, Columbia University Medical Center, New York, NY, USA. 3. Research Foundation for Mental Hygiene and the Department of Biostatistics, College of Physicians and Surgeons, Columbia University, New York City, New York, USA. 4. Department of Medicine, Columbia University Medical Center, New York, NY, USA. 5. Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA. 6. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. 7. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA. 8. Department of Neurology, Columbia University and the New York Presbyterian Hospital, New York, NY, USA. 9. Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA. 10. The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
Abstract
INTRODUCTION: Odor identification deficits characterize Alzheimer's disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. METHODS: In an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analyzed. RESULTS: In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among participants with intact olfactory (B-SIT ≥ 11/12 correct) and cognitive (Blessed Orientation Memory Concentration Test ≤ 5/28 incorrect) ability, 3.4% (4/117) transitioned to dementia during follow-up with no transitions in the 70-75 and 81-83 years age group quartiles. DISCUSSION: Odor identification testing adds value to global cognitive testing, and together can identify individuals who rarely transition to dementia, thereby avoiding unnecessary diagnostic investigation.
INTRODUCTION: Odor identification deficits characterize Alzheimer's disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. METHODS: In an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analyzed. RESULTS: In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among participants with intact olfactory (B-SIT ≥ 11/12 correct) and cognitive (Blessed Orientation Memory Concentration Test ≤ 5/28 incorrect) ability, 3.4% (4/117) transitioned to dementia during follow-up with no transitions in the 70-75 and 81-83 years age group quartiles. DISCUSSION: Odor identification testing adds value to global cognitive testing, and together can identify individuals who rarely transition to dementia, thereby avoiding unnecessary diagnostic investigation.
Authors: Guangyu Zhou; Jonas K Olofsson; Mohamad Z Koubeissi; Georgios Menelaou; Joshua Rosenow; Stephan U Schuele; Pengfei Xu; Joel L Voss; Gregory Lane; Christina Zelano Journal: Prog Neurobiol Date: 2021-02-25 Impact factor: 10.885
Authors: Jacob C Lucas; Zack Arambula; Alexandra M Arambula; Katherine Yu; Nathan Farrokhian; Linda D'Silva; Hinrich Staecker; Jennifer A Villwock Journal: Front Neurol Date: 2022-07-11 Impact factor: 4.086
Authors: Simon Niedenthal; Johannes Nilsson; Teodor Jernsäther; David Cuartielles; Maria Larsson; Jonas K Olofsson Journal: Iperception Date: 2021-06-11