Sukrit Narula1, Khader Shameer2, Alaa Mabrouk Salem Omar3, Joel T Dudley2, Partho P Sengupta4. 1. Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York. 2. Institute of Next Generation Healthcare, Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, New York. 3. Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Internal Medicine, Medical Division, National Research Center, Cairo, Egypt. 4. Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: partho.sengupta@mountsinai.org.
Abstract
BACKGROUND: Machine-learning models may aid cardiac phenotypic recognition by using features of cardiac tissue deformation. OBJECTIVES: This study investigated the diagnostic value of a machine-learning framework that incorporates speckle-tracking echocardiographic data for automated discrimination of hypertrophic cardiomyopathy (HCM) from physiological hypertrophy seen in athletes (ATH). METHODS: Expert-annotated speckle-tracking echocardiographic datasets obtained from 77 ATH and 62 HCM patients were used for developing an automated system. An ensemble machine-learning model with 3 different machine-learning algorithms (support vector machines, random forests, and artificial neural networks) was developed and a majority voting method was used for conclusive predictions with further K-fold cross-validation. RESULTS: Feature selection using an information gain (IG) algorithm revealed that volume was the best predictor for differentiating between HCM ands. ATH (IG = 0.24) followed by mid-left ventricular segmental (IG = 0.134) and average longitudinal strain (IG = 0.131). The ensemble machine-learning model showed increased sensitivity and specificity compared with early-to-late diastolic transmitral velocity ratio (p < 0.01), average early diastolic tissue velocity (e') (p < 0.01), and strain (p = 0.04). Because ATH were younger, adjusted analysis was undertaken in younger HCM patients and compared with ATH with left ventricular wall thickness >13 mm. In this subgroup analysis, the automated model continued to show equal sensitivity, but increased specificity relative to early-to-late diastolic transmitral velocity ratio, e', and strain. CONCLUSIONS: Our results suggested that machine-learning algorithms can assist in the discrimination of physiological versus pathological patterns of hypertrophic remodeling. This effort represents a step toward the development of a real-time, machine-learning-based system for automated interpretation of echocardiographic images, which may help novice readers with limited experience.
BACKGROUND: Machine-learning models may aid cardiac phenotypic recognition by using features of cardiac tissue deformation. OBJECTIVES: This study investigated the diagnostic value of a machine-learning framework that incorporates speckle-tracking echocardiographic data for automated discrimination of hypertrophic cardiomyopathy (HCM) from physiological hypertrophy seen in athletes (ATH). METHODS: Expert-annotated speckle-tracking echocardiographic datasets obtained from 77 ATH and 62 HCM patients were used for developing an automated system. An ensemble machine-learning model with 3 different machine-learning algorithms (support vector machines, random forests, and artificial neural networks) was developed and a majority voting method was used for conclusive predictions with further K-fold cross-validation. RESULTS: Feature selection using an information gain (IG) algorithm revealed that volume was the best predictor for differentiating between HCM ands. ATH (IG = 0.24) followed by mid-left ventricular segmental (IG = 0.134) and average longitudinal strain (IG = 0.131). The ensemble machine-learning model showed increased sensitivity and specificity compared with early-to-late diastolic transmitral velocity ratio (p < 0.01), average early diastolic tissue velocity (e') (p < 0.01), and strain (p = 0.04). Because ATH were younger, adjusted analysis was undertaken in younger HCM patients and compared with ATH with left ventricular wall thickness >13 mm. In this subgroup analysis, the automated model continued to show equal sensitivity, but increased specificity relative to early-to-late diastolic transmitral velocity ratio, e', and strain. CONCLUSIONS: Our results suggested that machine-learning algorithms can assist in the discrimination of physiological versus pathological patterns of hypertrophic remodeling. This effort represents a step toward the development of a real-time, machine-learning-based system for automated interpretation of echocardiographic images, which may help novice readers with limited experience.
Authors: Damini Dey; Piotr J Slomka; Paul Leeson; Dorin Comaniciu; Sirish Shrestha; Partho P Sengupta; Thomas H Marwick Journal: J Am Coll Cardiol Date: 2019-03-26 Impact factor: 24.094
Authors: Christina Luong; Zhibin Liao; Amir Abdi; Purang Abolmaesumi; Teresa S M Tsang; Hany Girgis; Robert Rohling; Kenneth Gin; John Jue; Darwin Yeung; Elena Szefer; Darby Thompson; Michael Yin-Cheung Tsang; Pui Kee Lee; Parvathy Nair Journal: Int J Cardiovasc Imaging Date: 2020-11-19 Impact factor: 2.357
Authors: Julian Betancur; Frederic Commandeur; Mahsaw Motlagh; Tali Sharir; Andrew J Einstein; Sabahat Bokhari; Mathews B Fish; Terrence D Ruddy; Philipp Kaufmann; Albert J Sinusas; Edward J Miller; Timothy M Bateman; Sharmila Dorbala; Marcelo Di Carli; Guido Germano; Yuka Otaki; Balaji K Tamarappoo; Damini Dey; Daniel S Berman; Piotr J Slomka Journal: JACC Cardiovasc Imaging Date: 2018-03-14
Authors: Manar D Samad; Alvaro Ulloa; Gregory J Wehner; Linyuan Jing; Dustin Hartzel; Christopher W Good; Brent A Williams; Christopher M Haggerty; Brandon K Fornwalt Journal: JACC Cardiovasc Imaging Date: 2018-06-13