| Literature DB >> 27882485 |
Carmen Martínez1,2,3,4, Olga Millán5,6,7,8, Montserrat Rovira9,10,7,8, Francesc Fernández-Avilés9,10,7,8, Anna López5,7, María Suárez-Lledó9, Enric Carreras10, Álvaro Urbano-Ispízua9,10,7,8, Mercè Brunet5,6,7,8.
Abstract
Information on pharmacodynamic monitoring after allogeneic hematopoietic cell transplantation (allo-SCT) to evaluate individual responses to immunosuppressive drugs is scarce. We studied the relationship between a panel of pharmacodynamic markers monitored during the first 3 months after transplant and the occurrence of graft-versus-host disease (GVHD). Lymphocyte activation assessed by intracellular ATP concentration in CD4+ T cells, a high percentage of CD8+ effector T cells, and a low percentage of CD4+ regulatory T (Treg) cells correlated significantly with GVHD. A cutoff value of 0.5 for the CD8+ effector T/Treg ratio provided the most accurate diagnosis of GVHD (sensitivity 58.8%, specificity 91%). These pharmacodynamic markers may provide an efficient complement to standard pharmacokinetic monitoring of immunosuppressive drugs after allo-SCT.Entities:
Keywords: Allogeneic stem cell transplantation; Graft-versus-host disease; Pharmacodynamics; T effector cells; Treg cells
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Year: 2016 PMID： 27882485 DOI： 10.1007/s12185-016-2145-5
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490