Literature DB >> 27878749

The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia.

Shui Liu1, Bowen Liu1, Zhao-Qing Luo2, Jiaming Qiu1, Xuan Zhou1, Gen Li1, Bing Zhang1, Xuming Deng1, Zhenguo Yang3, Jianfeng Wang4.   

Abstract

We reported the inhibition of α-Hemolysin (Hla) production in methicillin-resistant Staphylococcus aureus USA300 by osthole and further investigated the combination of osthole and baicalin in the treatment of staphylococcal pneumonia. Using cytotoxicity assays and a mouse model of intranasal lung infection, we evaluated the effect of combined therapy. Our results suggest that the combination of osthole and baicalin alleviated S. aureus-mediated A549 cell injury and protected mice from S. aureus pneumonia.

Entities:  

Keywords:  Alpha-hemolysin; Baicalin; Osthole; Staphylococcus aureus

Mesh：

Substances：

Year:  2016        PMID： 27878749     DOI： 10.1007/s11274-016-2162-9

Source DB:  PubMed          Journal:  World J Microbiol Biotechnol        ISSN： 0959-3993            Impact factor:   3.312


  18 in total

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7.  Baicalin protects mice from Staphylococcus aureus pneumonia via inhibition of the cytolytic activity of α-hemolysin.

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  5 in total

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