Literature DB >> 27874907

Natural products as mediators of disease.

Neha Garg1, Tal Luzzatto-Knaan, Alexey V Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J Floros, Daniel Petras, Rachel Gregor, Pieter C Dorrestein, Vanessa V Phelan.   

Abstract

Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

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Year:  2016        PMID： 27874907      PMCID： PMC5299058          DOI： 10.1039/c6np00063k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  335 in total

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  16 in total

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